IgA deficiency in children: A clinical study with special reference to intestinal findings

Savilahti, E; Pelkonen, P.; Visakorpi, J. K.

doi:10.1136/adc.46.249.665

Cited by 71 publications

(23 citation statements)

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“…Our study and the one reported by Sinclair et al demonstrate that the prevalence of IgA deficiency is between 3 and 140 times higher in a population that undergoes testing for celiac disease by a case-finding strategy compared with testing the general population for IgA deficiency (4,5,24 ). The prevalence of celiac disease in IgA-deficient patients who were properly evaluated (18%) was within the range of previous estimates (12% to 31%) obtained from highly selected patient groups with gastrointestinal symptoms (7)(8)(9). Recent investigations report an 8% to 10% prevalence of celiac disease in IgA-deficient patients among blood donors and consecutively diagnosed cases of IgA deficiency (6,10 ).…”

Section: Discussionsupporting

confidence: 76%

Celiac Disease and IgA Deficiency: Complications of Serological Testing Approaches Encountered in the Clinic

2008

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Section: Discussionsupporting

confidence: 76%

Celiac Disease and IgA Deficiency: Complications of Serological Testing Approaches Encountered in the Clinic

2008

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“…Encontramos na amostra estudada a presença de outras doenças crônicas, também referidas pela literatura [38][39][40][41][42][43] , o que reforça a importância de investigar estas doenças nos pacientes com DC, assim como a investigação da DC nos indivíduos com, por exemplo, diabetes, doenças da tireói-de, doenças reumáticas e doença inflamatória intestinal.…”

Section: Discussionunclassified

Celiac disease: clinical characteristics and methods used in the diagnosis of patients registered at the Brazilian Celiac Association

2001

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ResumoObjetivo: avaliar as características clínicas e os métodos utilizados no diagnóstico dos pacientes cadastrados na Associação dos Celíacos do Brasil -Seção São Paulo.Métodos: foi enviado por correio um questionário a respeito das características clínicas e dos métodos diagnósticos da doença celí-aca para 584 membros cadastrados.Resultados: foram analisados 289 questionários respondidos (49,5%) dos 584 enviados. Quanto às características clínicas da doença celíaca no momento do diagnóstico, observou-se que na amostra estudada a forma clássica foi mais freqüente (88,9%) do que a forma não clássica (11,1%). Nos últimos cinco anos houve aumento da proporção da forma clássica tardia de 44,5% para 64,2% (p=0,004) e da forma não clássica de 5,2% para 16,8% (p=0,005). O tempo de duração dos sintomas até o estabelecimento do diagnóstico foi superior a 1 ano em 75% dos pacientes com manifestação clínica não clássica. Biópsia de intestino delgado não foi realizada no momento do diagnóstico em 19% dos pacientes. Observou-se que, nos últimos 5 anos, maior número de pacientes (24,4%) não realizaram biópsia de intestino delgado no momento do diagnóstico em relação aos realizados há 5 ou mais anos (11,1%) (p=0,007).Conclusões: na amostra estudada, a forma clássica continua sendo a manifestação clínica mais freqüente da doença celíaca. Apesar do predomínio da forma clássica tardia, observamos aumento da proporção da forma não clássica. 19% dos pacientes diagnosticados como portadores de doença celíaca não realizaram biópsia de intestino delgado no momento do diagnóstico, especialmente nos últimos 5 anos, apesar de a caracterização da atrofia vilositária subtotal ou total da mucosa do intestino delgado ser um critério imprescindível para o diagnóstico de doença celíaca.J Pediatr (Rio J) 2001; 77 (2): 131-8: doença celíaca, sinais e sintomas, diagnóstico, diarréia, desnutrição protéico-energética. AbstractObjective: to evaluate the clinical characteristics and methods used in the diagnosis of patients registered at the Brazilian Celiac Association (BCA).Methods: a questionnaire about clinical characteristics and diagnostic methods in celiac disease was mailed to 584 members of the BCA.Results: we received 292 responses for 584 questionnaires mailed (49.5%). The clinical characteristics of celiac disease in the sample we analyzed showed that the most frequent type was the classical mode (88.9%), while the atypical mode was present in only 11.1% of patients at the time of diagnosis. Increased incidence of both late diagnosed classical mode (44.5% to 64.2%; P=.004) and atypical mode (5.2% to 16.8%; P=.005) has been observed in the last 5 years. Duration of symptoms before diagnosis was greater than 1 year in 75% patients with atypical manifestation. Intestinal biopsy was not performed in 19% of the cases at the time of diagnosis. It was observed that in the last 5 years intestinal biopsy was not performed for a larger number of patients (24.4%) than in the previous period (only 11.1%) (P=.007).Conclusions: classical mode is stil...

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“…More widespread use of serologic markers has facilitated diagnosis of celiac disease in children [52]; this alone does not entirely explain the decrease in diarrheal manifestations, as many long-term studies of adult and pediatric patients predating the use of these markers have documented this shift in clinical presentation [44,54]. Of note, since the initial availability of sensitive and specific serological assays over the past two decades, the gap between initial presentation and diagnosis in symptomatic children has been gradually fading [55,56]. This reduction in duration of symptoms has also been documented in adults [44].…”

Section: Presentation Of Celiac Diseasementioning

confidence: 98%

Epidemiology and clinical presentations of celiac disease

2012

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Evidence of the prevalence of celiac disease comes from serological screening studies. These have revealed that celiac disease is common, occurring in about 1 % of the population worldwide. There are some countries with higher prevalence rates such as Finland and others with lower rates, for example Germany. The disease is found in most continents and appears to be increasing. Most people with the disease are not currently diagnosed though women are diagnosed more frequently than men. The mode of presentation has changed both in children and adults with diarrhea and a malabsorption syndrome becoming less common. Abdominal pain and growth issues are major modes of presentation in children, while anemia, osteoporosis, and recognition at endoscopy performed for GERD are seen as modes of presentation in adults. Screening of at risk groups is a major mode of presentation for both adults and children.

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IgA deficiency in children: A clinical study with special reference to intestinal findings

Cited by 71 publications

References 24 publications

Celiac Disease and IgA Deficiency: Complications of Serological Testing Approaches Encountered in the Clinic

Celiac Disease and IgA Deficiency: Complications of Serological Testing Approaches Encountered in the Clinic

Celiac disease: clinical characteristics and methods used in the diagnosis of patients registered at the Brazilian Celiac Association

Epidemiology and clinical presentations of celiac disease

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