Some Hormonal Changes Before and After Vertical Banded Gastroplasty for Severe Obesity

Abstract

VBG and consequent weight loss favorably influence the hormonal abnormalities in the morbidly obese. Further studies are needed to make clear a relationship between this and other parameters of metabolic syndrome. The hormonal abnormalities may influence the indications for surgery in less than morbidly obese patients with metabolic syndrome.

Thyroid disorders and gastrointestinal and liver dysfunction: A state of the art review

“…The relationship with free thyroid hormones is less clear. Furthermore, studies into the effect of weight loss on thyroid function in people with morbid obesity have given inconsistent results [81,[83][84][85][86][87]. It has been reported that moderate weight loss results in a decrease in T3 with minimal changes in other thyroid hormone homeostasis parameters, suggesting that a decrease in peripheral conversion of T4 to T3 is at least in part responsible for the observed changes in thyroid hormone homeostasis [88].…”

Relationship between Thyroid Volume and Iodine, Leptin, and Adiponectin in Obese Women before and after Weight Loss

“…Most studies have demonstrated clinically and biologically insignificant high thyroid-stimulating hormone (TSH), low tri-iodothyronine (T3), low thyroxin (T4), and increased thyroid volume in the obese population [1][2][3] . There are few reports about the relationship between weight loss and thyroid volume and function [4][5][6][7] . In a recent study, we reported higher goiter prevalence and increased thyroid volume in obese women and a reduction in thyroid volume after 1 10% weight loss in obese women [6] .…”

Thyroid Function and Insulin Sensitivity Before and After Bilio-pancreatic Diversion

“…Gastric bypass seems to restore thyroid function in hypothyroid patients independently of final BMI [20][21][22][23], while gastric banding seems to reduce TSH levels, with no effect on fT3 and fT4 levels [23,24]. This phenomenon is often attributed to the loss in body weight, which seems to correlate to TSH levels; however, changes in the nutritional intake interfering with peripheral fT3 de-iodination and modifications of leptin concentrations seem to play a role in the decrease of TSH secretion.…”

“…This phenomenon is often attributed to the loss in body weight, which seems to correlate to TSH levels; however, changes in the nutritional intake interfering with peripheral fT3 de-iodination and modifications of leptin concentrations seem to play a role in the decrease of TSH secretion. Most frequently a reduction of fT3 levels after BPD is reported, which usually attributed to the significant body weight reduction observed in these patients [13,23,24].…”