Some Data From a Correlated Anatomical, Physiological and Behavioristic Study of the Reproductive Cycle in the Female Guinea Pig

Young, William C.; Myers, Hugh I.; Dempsey, Edward W.

doi:10.1152/ajplegacy.1933.105.2.393

Cited by 21 publications

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“…14). Since ovulation occurs within hours of vaginal opening (Young, Myers & Dempsey, 1933), it is tempting to link this appearance with the processes leading to ovulation. Along the same line of thought, it may be relevant that the theca interna of follicles undergoing atresia showed fewer oxytocin-binding sites than other large follicles (Garrís & Foreman, 1984).…”

Section: Resultsmentioning

confidence: 99%

Autoradiographical localization of oxytocin-binding sites in the guinea-pig ovary at different stages of the oestrous cycle

Zhang¹,

Dreifuss²,

Dubois‐Dauphin³

et al. 1991

Journal of Endocrinology

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The discovery that oxytocin is synthesized and stored in corpora lutea of ruminants has fostered a renewed interest in the possible roles of oxytocin in ovarian function. In the present study we describe the distribution of binding sites for oxytocin in the guinea-pig ovary. Sections were reacted with a radioiodinated oxytocin antagonist (125I-labelled OTA) to yield autoradiograms on film. Specific binding sites for oxytocin were defined as those which bound 0.05 nmol 125I-labelled OTA/l and where 1 mumol non-radioactive oxytocin/l displaced the radioactivity. 125I-Labelled OTA consistently labelled the ovarian stroma and the theca interna, but not the corpora lutea, the granulosa cells or the theca externa. The amount of 125I-labelled OTA bound to ovarian stroma and theca interna was high in animals killed during dioestrus, and low during and shortly after oestrus. These data suggest that the binding sites are regulated by steroid hormone levels and that in the guinea-pig ovary oxytocin could exert a role in follicular steroidogenesis, maturation or ovulation rather than in luteal function. Oxytocin-binding sites were also shown in the uterus but their numbers varied only slightly during the cycle.

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Section: Resultsmentioning

confidence: 99%

Autoradiographical localization of oxytocin-binding sites in the guinea-pig ovary at different stages of the oestrous cycle

Zhang¹,

Dreifuss²,

Dubois‐Dauphin³

et al. 1991

Journal of Endocrinology

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“…Stockard & Papanicolaou (1917) first related changes in the vaginal smear to concurrent events taking place in the ovaries and found that ovulation and the entry of leucocytes into the vaginal fluid tended to be coincident. Leucocytic infiltration of the vaginal smear after complete cornification has been taken to indicate ovulation by Young, Myers & Dempsey (1933) and Hermreck & Greenwald (1964). It is likely that the influx of leuco¬ cytes arises under the influence of progesterone.…”

Section: Discussionmentioning

confidence: 99%

Light and the Timing of Ovulation in the Guinea-Pig

Donovan¹,

Lockhart²

1972

Reproduction

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X‐irradiation of the ovaries of guinea‐pigs and its effect on subsequent pregnancies

Genther

1934

Am. J. Anat.

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A previous publication (Genther, '31) dealt with the irradiation of the ovaries of guinea-pigs and its effect on the oestrous cycle. It was found, regardless of the nature of the 1 THE AMERICAN JOURNAL O F ANATOMY, VOL. 55, N O . 1 JULY, 1934 2 IDA T. GENTHER X-RAYED OVARIES AND SUBSEQUENT PREGNANCIES 3soon after irradiation, when the cycles were still apparently normal, and later when the cycles were very abnormal.IV. Irradiation of the ovaries of very young animals, from 1 week of age to sexual maturity, to observe the effects on the cycles and snbsequent pregnancies.The experiments extended over a Long period of time, so that both the early and late effects of the irradiation could be observed. MATERIALS AND METHODSThe majority of animals used were laboratory raised. Uniformity of behavior was shown in that sexual maturity was reached between the weights of 275 and 315 gm. Cycles were normal and regular with few exceptions. Many controls were kept under the same conditions as the irradiated ones.The irradiation was carried out at the Children's Hospital under the direction of Dr. William Doughty, roentgenologist ; the treatments were given by Mrs. Mary Ware and Miss Ida V. Holt, x-ray technicians. The following setup was used : Milliamps, 5 Peak kilovolts, 165 Distance, 50 em. Port, 19 em. Filters, 1 mm. A1 + 2 mm. Cu.A half hour exposure was equivalent to 360 r units, calculated on the basis of 12 r units per minute, which were accurately measured. The minimum sterilization dose consisted of six half hour exposures, or 2160 r units, given within a week, the Lighter treatment of four exposures, or 1440 r units, given on successive days.A specially constructed box permitted four or five animals to be treated a t one time. Since the irradiation was dorsal, the animals were allowed to sit in a natural position, being held in place by a wooden halter that fitted snugly over the body behind the fore legs. No anaesthetic was used, since they iisually rested quietly. The entire body was covered with lead plates, except for a small strip over the region of the ovaries. In almost all ovaries studied thus far, both of a pair had

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Some Data From a Correlated Anatomical, Physiological and Behavioristic Study of the Reproductive Cycle in the Female Guinea Pig

Cited by 21 publications

References 0 publications

Autoradiographical localization of oxytocin-binding sites in the guinea-pig ovary at different stages of the oestrous cycle

Autoradiographical localization of oxytocin-binding sites in the guinea-pig ovary at different stages of the oestrous cycle

Light and the Timing of Ovulation in the Guinea-Pig

X‐irradiation of the ovaries of guinea‐pigs and its effect on subsequent pregnancies

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