Some biochemical studies on trans fatty acid-containing diet

El-Aal, Yasmin Ali Abd; Abdel-Fattah, Doaa; Ahmed, Khalifa

doi:10.1016/j.dsx.2019.03.029

Cited by 28 publications

(8 citation statements)

References 57 publications

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“…Edible fats rich in saturated fatty acids are often used in foods to create desirable functional attributes, such as solidlike textures, because of their ability to form crystalline networks. , These fat sources are often derived from plant-based liquid oils using hydrogenation, which can lead to the formation of trans fatty acids as a side product . Dietary intake of foods rich in trans and saturated fatty acids can have adverse effects on human health, including promoting cardiovascular diseases, cancer, diabetes, and other chronic conditions. , The food industry is therefore searching for healthier ways of creating solidlike textures in fatty foods . High internal phase emulsions (HIPEs) offer a promising approach for converting liquid oils into solidlike fats without using saturated or trans fatty acids .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of OSA Starch/Chitosan Polysaccharide-Based High Internal Phase Emulsion via Altering Interfacial Behaviors

Yan

McClements

Zhu

et al. 2019

J. Agric. Food Chem.

160

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This paper attempted to construct a high internal phase emulsion (HIPE) through altering interfacial behaviors using the electrostatic interaction between positive chitosan and negative octenyl succinic anhydride (OSA) starch. The partial polysaccharide complex of OSA starch/chitosan was used to stabilize HIPE, which was able to adsorb at the oil droplet interface and prevent the coalescence of oil droplets. The wettability of OSA starch was enhanced with the addition of positively charged chitosan, leading to the formation of partial complexes. The impact of pH and concentration of chitosan on the droplet size, surface charge, and interface behavior were investigated, and the formation of the polysaccharide complex was further confirmed by atomic force microscopy. The presence of the OSA starch/chitosan complex facilitated the formation of stable HIPE with a gel-like structure and satisfactory centrifugal and oxidative stability. These results are useful to provide information for fabricating polysaccharide-based HIPE delivery systems, which may help expand their application in the food industry.

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Section: Introductionmentioning

confidence: 99%

Fabrication of OSA Starch/Chitosan Polysaccharide-Based High Internal Phase Emulsion via Altering Interfacial Behaviors

Yan

McClements

Zhu

et al. 2019

J. Agric. Food Chem.

160

View full text Add to dashboard Cite

show abstract

“…[ 19 ] demonstrated that long-term consumption of high SFA diet induced obesity in mice. Related studies showed that the consumption of TFA was related to changes in blood lipids [ 21 ] and obesity in animals and humans [ 22 ]. All these studies were similar to our outcomes.…”

Section: Discussionmentioning

confidence: 99%

High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice

et al. 2022

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Background Excessive consumption of high-fat diets is associated with disordered metabolic responses, which may lead to chronic diseases. High-fat diets containing different types of fatty acids lead to distinct alterations in metabolic responses of gut-brain axis. Methods In our study, normal male C57BL/6J mice were fed to multiple high fatty acid diets (long-chain and medium-chain saturated fatty acid, LCSFA and MCSFA group; n-3 and n-6 polyunsaturated fatty acid, n-3 and n-6 PUFA group; monounsaturated fatty acid, MUFA group; trans fatty acid, TFA group) and a basic diet (control, CON group) for 19 weeks. To investigate the effects of high-fat diets on metabolic responses of gut-brain axis in obese mice, blood lipids were detected by fast gas chromatography, and related proteins in brain and intestine were detected using Western blotting, ELISA, and immunochemistry analysis. Results All high-fat diets regardless of their fatty acid composition induced obesity, lipid disorders, intestinal barrier dysfunction, and changes in gut-brain axis related factors except basal diet in mice. For example, the protein expression of zonula occludens-1 (ZO-1) in ileum in the n-3 PUFA group was higher than that in the MCSFA group (P < 0.05). The expressions of insulin in hippocampus and leptin in ileum in the MCSFA group significantly increased, compared with other groups (all Ps < 0.05). Conclusion The high MCSFA diet had the most effect on metabolic disorders in gut-brain axis, but the high n-3 PUFA diet had the least effect on changes in metabolism.

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“…Hydrogenated vegetable oils are trans saturated fatty acids with an increased melting point and were established as alternatives to lard and butter in processed foods. While trans fatty acids have been reported to be associated with health disorders such as diabetes, cardiovascular disease, obesity, and cancers such as mammary and prostatic [41], no report indicates the gastrointestinal tumorigenic effects. Cocoa butter is composed of similar fatty acids as lard and beef tallow, however, the mice fed Cocoa diet kept lean with a healthy gastric mucosa.…”

Section: Discussionmentioning

confidence: 99%

Dietary Fat-Accelerating Leptin Signaling Promotes Protumorigenic Gastric Environment in Mice

et al. 2019

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Excess of fat intake leads to obesity and causes a variety of metabolic diseases and cancer. We previously demonstrated that high-lard diet induces intestinal metaplasia, a precancerous lesion of the stomach mediated by leptin signaling. This study aims to investigate which kinds of dietary fat cause the intestinal metaplasia onset. We fed eight kinds of high-fat diets (HFDs) of animal or plant origin to mice evaluated their effect on gastric pathogenesis. Five types of dietary fat were divided according to their observed effects: Obese with high metaplasia (group I; beef tallow, lard, and hydrogenated coconut oil), non-obese with high metaplasia (group II; linseed oil), obese without metaplasia (group III; corn oil and olive oil), non-obese without metaplasia (group IV, soybean oil) and lean without metaplasia (group V; cocoa butter). The group I and II diets induced leptin, phosphorylated leptin receptor (ObR), signal transducer and activator 3 (STAT3), and increased intracellular β-catenin accumulation in the stomach. Moreover, mice fed these HFDs with 1-methyl-3-nitro-1-nitrosoguanidine (MNNG), a gastric carcinogen, and further accelerated dysplasia in the stomach. Lactobacillus occupancy in the stomach increased in all HFDs except hydrogenated coconut oil. Our findings suggest that HFDs inducing leptin signaling accelerate the enhancement of protumorigenic gastric microenvironment independent of body mass gain or microbiome changes.

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Some biochemical studies on trans fatty acid-containing diet

Cited by 28 publications

References 57 publications

Fabrication of OSA Starch/Chitosan Polysaccharide-Based High Internal Phase Emulsion via Altering Interfacial Behaviors

Fabrication of OSA Starch/Chitosan Polysaccharide-Based High Internal Phase Emulsion via Altering Interfacial Behaviors

High-fat diets containing different types of fatty acids modulate gut-brain axis in obese mice

Dietary Fat-Accelerating Leptin Signaling Promotes Protumorigenic Gastric Environment in Mice

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