Some aspects of the safety of Russian vaccines against COVID-19 in employees of medical organizations

Abstract

Medical staff and teachers are at high risk of infection. In this connection, it seems relevant to study the effectiveness of the safety of preventive measures aimed at reducing the incidence. A separate issue of which is the results of vaccination of risk groups for infection with SARS-CоV2. The purpose of the study is to evaluate the frequency of registration of post-vaccination reactions of various vaccines against COVID-19 approved for use in Russia among medical staff and faculty of medical higher educational institutions (HEI). A cross-sectional, retrospective, cross-sectional online study was conducted between January and March 2022. The survey involved the teaching staff and medical workers of medical higher educational institutions (HEI) and their subordinate clinics (n = 6032). The majority of vaccinated employees of medical institutions and medical schools had a good tolerability of immunization.Serious adverse events were not registered. A higher incidence of PE and NE was observed in respondents after the first vaccination (p < 0.05). Most often, respondents reported an increase in body temperature (6.9–21.7 %), myalgia (5.5–21.2 %), general weakness (8.4–23.6 %), arthralgia (1.7–9.7 %), local reactions (0.8–16.7 %). In more than 85 % of cases, the above complaints were detected in the first 3 days from the moment of vaccination. A history of COVID-19 infection increased the risk of local and systemic adverse reactions. Gender characteristics of the post-vaccination reaction were revealed, manifested by more frequent registration of NE and PE in men under 35. An inverse relationship between the frequency of NE and PE with age was determined. The presence of comorbid pathology in two or more systems, regardless of age, increased the risk (OR) of various PE and NE from 1.047 to 1.539. The results can be used as an additional tool when planning a personalized approach to vaccinating healthcare workers against COVID-19.