Somatotopic studies on cerebellar interpositus neurons.

Eccles, J. C.; Rantucci, T.; Rosén, I.; Scheid, P.; Táboríková, H

doi:10.1152/jn.1974.37.6.1449

Cited by 19 publications

(4 citation statements)

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“…A route involving primary afferent collaterals to the cuneate nucleus, synaptic relay in that nucleus and subsequent input to motor cortex as a result of excitation of thalamocortical neurones via lemniscal fibres is the most probable. However, for all but the earliest responses (latencies û ca 10 ms) contributions cannot be excluded from less direct pathways which might include the spino-cervical system andÏor a path involving a cortico-cortical relay to motor cortex from primary somatosensory cortex andÏor a path involving a cerebellar relay, most probably involving transmission through nucleus interpositus (see for example Eccles et al 1974). …”

Section: Discussionmentioning

confidence: 99%

Central regulation of motor cortex neuronal responses to forelimb nerve inputs during precision walking in the cat

Marple‐Horvat

Armstrong

1999

The Journal of Physiology

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To understand the role(s) in movement control of any pathway that forwards information from receptors in the limbs to some part of the central nervous system, information must be obtained regarding the extent to which, during active movement, its ability to transmit is subject to regulation (modulation; sometimes termed gating) by central mechanisms. Moreover, the possibility must be explored that such mechanisms may vary their influence with the type of movement or with its phases (for a detailed review, see Prochazka, 1989). Thus, to consider only the context of locomotor movements, the responsiveness of spinal reflex paths to inputs from both muscle and skin receptors is now known to differ between the presence and absence of stepping movements and to

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Section: Discussionmentioning

confidence: 99%

Central regulation of motor cortex neuronal responses to forelimb nerve inputs during precision walking in the cat

Marple‐Horvat

Armstrong

1999

The Journal of Physiology

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“…Receptive fields have previously been studied extensively in decerebrate paralysed cats by Eccles et al (1974a) and by Eccles, Rosen, Scheid & Taborikova (1974 c). These authors also found that the forelimb was frequently represented (in 89 % of cells) but they encountered forelimb/hind-limb convergence more often (in 60 % as compared with our 29 % of cells).…”

Section: Somatosensory Receptive Fieldsmentioning

confidence: 99%

“…Larsen & Yumiya, 1979) indicating that the 'patchy' somatotopy detectable in the decerebrate cat (e.g. Eccles et al 1974a) is maintained in the awake animal.…”

Section: Somatosensory Receptive Fieldsmentioning

confidence: 99%

Discharges of nucleus interpositus neurones during locomotion in the cat.

Armstrong¹,

Edgley²

1984

The Journal of Physiology

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SUMMARY1. Extracellular recordings were made from ninety-five cerebellar nuclear neurones in the cat. All were studied during periods of steady walking at 0'5 m/s and most were also studied in the resting animal.2. Most neurones were in nucleus interpositus anterior; forty-four cells were shown by antidromic invasion to project to the mid-brain.3. Most neurones discharged tonically in the absence of overt movements and the mean rate was 42 impulses/s (S.D.+ 23). During locomotion the mean rate was 68 impulses/s (S.D.+ 32).4. In all but seven neurones the discharge during locomotion was frequency modulated but in different neurones the depth of modulation varied from 5 to 161 impulses/s (mean 52 impulses/s; S.D. + 30) and the time of peak discharge relative to the step cycle in the ipsilateral forelimb also varied widely.5. Despite the individual differences the population as a whole was much more active during forelimb swing than during stance, both in numbers of neurones strongly active and in over-all average discharge rate (74 impulses/s as compared with 55).6. Most neurones had tactile receptive fields on the ipsilateral forelimb while others received input from head and neck or from both ipsilateral limbs. The tendency to discharge preferentially during early swing was greatest for the first group, especially the subpopulations with receptive fields around or proximal to the elbow.7. Cells encountered in close sequence during a micro-electrode track had similarly located receptive fields and usually showed similar patterns of discharge during locomotion.8. These findings are discussed in relation to the suggestion by Orlovsky (1972 a, b, c) that nucleus interpositus assists in regulating locomotion by evoking rubrospinal discharges which facilitate the flexor muscle activities produced by the spinal mechanisms reponsible for generating the swing phase of the step cycle.

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“…Many cerebellar regions use visual, somatosensory, and vestibular sensory signals to control movements of the body (Eccles et al, 1974; Ito, 1984). Recent studies of the vermis and rostral fastigial nucleus (rFN) have shown that vestibular sensory signals in these regions are transformed into signals that describe the body’s movement in space (Shaikh et al, 2005a,b; Brooks and Cullen, 2009).…”

Section: Introductionmentioning

confidence: 99%

Convergence of Vestibular and Neck Proprioceptive Sensory Signals in the Cerebellar Interpositus

et al. 2013

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The cerebellar interpositus nucleus (IN) contributes to controlling voluntary limb movements. We hypothesized that the vestibular signals within the IN might be transformed into coordinates describing the body’s movement, appropriate for controlling limb movement. We tested this hypothesis by recording from IN neurons in alert squirrel monkeys during vestibular and proprioceptive stimulation produced during (1) yaw head-on-trunk rotation about the C1–C2 axis while in an orthograde posture and (2) lateral side-to-side flexion about the C6 –T3 axis while in a pronograde posture. Neurons (44/67) were sensitive to vestibular stimulation (23/44 to rotation and translation, 14/44 to rotation only, 7/44 to translation only). Most neurons responded during contralateral movement. Neurons (29/44) had proprioceptive responses; the majority (21/29) were activated during neck rotation and lateral flexion. In all 29 neurons with convergent vestibular and neck proprioceptive input those inputs functionally canceled each other during all combined sensory stimulation, whether in the orthograde or pronograde posture. These results suggest that two distinct populations of IN neurons exist, each of which has vestibular sensitivity. One population carries vestibular signals that describe the head’s movement in space as is traditional for vestibular signals without proprioceptive signals. A second population of neurons demonstrated precise matching of vestibular and proprioceptive signals, even for complicated stimuli, which activated the semicircular canals and otolith organs and involved both rotation and flexion in the spine. Such neurons code body (not head) motion in space, which may be the appropriate platform for controlling limb movements.

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Somatotopic studies on cerebellar interpositus neurons.

Cited by 19 publications

References 0 publications

Central regulation of motor cortex neuronal responses to forelimb nerve inputs during precision walking in the cat

Central regulation of motor cortex neuronal responses to forelimb nerve inputs during precision walking in the cat

Discharges of nucleus interpositus neurones during locomotion in the cat.

Convergence of Vestibular and Neck Proprioceptive Sensory Signals in the Cerebellar Interpositus

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