Solvent extraction of butanol from synthetic solution and fermentation broth: Batch and continuous studies

Khedkar, Manisha A.; Nimbalkar, Pranhita R.; Gaikwad, Shashank G.; Chavan, Prakash V.; Bankar, Sandip B.

doi:10.1016/j.seppur.2020.117058

Cited by 11 publications

(6 citation statements)

References 35 publications

(61 reference statements)

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“…Continuous removal of a fermentation product using an in situ or in stream product recovery (ISPR, also called extractive bioconversion) process allows avoiding product retro-inhibition as well as antimicrobial effect of the product if applicable, as demonstrated for several molecules produced by fermentation [28] such as alcohols (ethanol [29], butanol [30], [31]) and organic acids [32] (3-hydroxypropionic acid [33], [34], lactic acid [35]). In the case of biotechnological production of p-HCAs, continuous product removal is expected to detoxify the fermentation medium, remove the solubility limitation and enhance the productivity.…”

Section: Introductionmentioning

confidence: 99%

Solvent selection strategy for an ISPR (In Situ/In stream product recovery) process: The case of microbial production of p-coumaric acid coupled with a liquid-liquid extraction

Combes

Rivera

Clément

et al. 2021

Separation and Purification Technology

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This work reports on a solvent selection for the liquid-liquid extraction of p-coumaric acid produced by an engineered strain of Saccharomyces cerevisiae. The solvent selection is a key point of liquid-liquid extraction processes and this work describes a simple strategy to choose a suitable solvent for an in situ or in stream product recovery (ISPR) process during bioconversion. ISPR processes allow to limit the inhibition caused by end-products accumulation in the fermentation medium. The strategy consists in scoring different solvents based on different criteria weighted according to their significance for the process. Extraction performance, solvent biocompatibility and compatibility with materials, were chosen as essential criteria and the first two were assessed experimentally using distribution coefficients and flow cytometry, respectively. Following this first step, three solvents were selected as candidates for the process of interest and ranked according to the process needs using secondary criteria, namely safety, sourcing and price. Finally, oleyl alcohol obtained the highest score and was therefore considered as the most suitable candidate for an ISPR process with the aim of continuously extracting p-coumaric acid from the fermentation medium.This work is a first step towards the implementation of integrated extractive bioconversion for the production of bio-based molecules such as p-hydroxycinnamic acids and derivatives.

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Section: Introductionmentioning

confidence: 99%

Solvent selection strategy for an ISPR (In Situ/In stream product recovery) process: The case of microbial production of p-coumaric acid coupled with a liquid-liquid extraction

Combes

Rivera

Clément

et al. 2021

Separation and Purification Technology

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“…The most widely known is the ethanol production by the yeast Saccharomyces cerevisiae (which will be further analyzed in Section 4). Another fermentation type is the butanol production by Clostridia [8]. This anaerobic fermentation is characterized by the production of Acetone -Ethanol-Butanol in molar ratio 3:6:1.…”

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confidence: 99%

“…During the acidogenic phase, there is production of acetic and butyric acids; therefore, there is a decrease in the pH of the medium. In this condition, the microorganism reconverts the acids into solvents (solventogenic phase) [8]. The butanol yield is low, and its recovery is very energy demanding; however, butanol has several advantages with respect to ethanol (e.g., high energy content, high burning efficiency, low hygroscopicity, and low volatility).…”

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confidence: 99%

“…The butanol yield is low, and its recovery is very energy demanding; however, butanol has several advantages with respect to ethanol (e.g., high energy content, high burning efficiency, low hygroscopicity, and low volatility). Thus, several innovative solutions for butanol production are currently being investigated [8].…”

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confidence: 99%

“…The last step in the biofuel production is the recovery, which is also considered as highly energy demanding. For this reason, there are dedicated studies in the literature specifically dedicated to its optimization [8,9]. The production of biofuels by microbial fermentation goes back to the second half of the 19th Century.…”

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confidence: 99%

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The “Zero Miles Product” Concept Applied to Biofuel Production: A Case Study

et al. 2021

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To make biofuel production feasible from an economic point of view, several studies have investigated the main associated bottlenecks of the whole production process through approaches such as the “cradle to grave” approach or the Life Cycle Assessment (LCA) analysis, being the main constrains the feedstock collection and transport. Whilst several feedstocks are interesting because of their high sugar content, very few of them are available all year around and moreover do not require high transportation’ costs. This work aims to investigate if the “zero miles” concept could bring advantages to biofuel production by decreasing all the associated transport costs on a locally established production platform. In particular, a specific case study applied to the Technical University of Denmark (DTU) campus is used as example to investigate the advantages and feasibility of using the spent coffee grounds generated at the main cafeteria for the production of bioethanol on site, which can be subsequently used to (partially) cover the campus’ energy demands.

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