Solvent-Dependent Formation of Three New Bi-Metal–Organic Frameworks Using a Tetracarboxylic Acid

Köppen, Milan; Meyer, Vanessa; Ångström, Jonas; Inge, A. Ken; Stock, Norbert

doi:10.1021/acs.cgd.8b00439

Cited by 44 publications

(22 citation statements)

References 41 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to ellagic acid, these are naturally occurring therapeutic phenolic molecules, making ellagic acid an appropriate choice of ligand to combine with Bi 3+ for the development of a potentially biocompatible and bioactive MOF. So far, the use of bismuth in the synthesis of MOFs has been fairly limited, with only seven Bi( iii )-MOFs that have been reported to demonstrate porosity to nitrogen. ,,− As all seven are exclusively based on synthetic carboxylate ligands, this begs the question, what new MOF structures can be acquired using Bi 3+ and phenol-based linkers such as ellagic acid? The resulting material could potentially combine the biocompatible and bioactive features of both the metal cation and the organic linker, and would ideally be synthesized using green aqueous conditions.…”

Section: Introductionmentioning

confidence: 99%

A Robust and Biocompatible Bismuth Ellagate MOF Synthesized Under Green Ambient Conditions

et al. 2020

Self Cite

View full text Add to dashboard Cite

The first bioinspired microporous metal–organic framework (MOF) synthesized using ellagic acid, a common natural antioxidant and polyphenol building unit, is presented. Bi 2 O(H 2 O) 2 (C 14 H 2 O 8 )· n H 2 O (SU-101) was inspired by bismuth phenolate metallodrugs, and could be synthesized entirely from nonhazardous or edible reagents under ambient aqueous conditions, enabling simple scale-up. Reagent-grade and affordable dietary supplement-grade ellagic acid was sourced from tree bark and pomegranate hulls, respectively. Biocompatibility and colloidal stability were confirmed by in vitro assays. The material exhibits remarkable chemical stability for a bioinspired MOF (pH = 2–14, hydrothermal conditions, heated organic solvents, biological media, SO 2 and H 2 S), attributed to the strongly chelating phenolates. A total H 2 S uptake of 15.95 mmol g –1 was recorded, representing one of the highest H 2 S capacities for a MOF, where polysulfides are formed inside the pores of the material. Phenolic phytochemicals remain largely unexplored as linkers for MOF synthesis, opening new avenues to design stable, eco-friendly, scalable, and low-cost MOFs for diverse applications, including drug delivery.

show abstract

Section: Introductionmentioning

confidence: 99%

A Robust and Biocompatible Bismuth Ellagate MOF Synthesized Under Green Ambient Conditions

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…11,12 The almost infinite possible combinations for designing new MOFs with different chemical properties, topologies, pore sizes and shapes, 8,9,12,13 has allowed an amazing growth in this field, with more than 90,000 different structures reported so far. [14][15][16][17] When proposing MOFs for biomedical applications, they require high biocompatibility and low accumulation in cells. The vast number of MOFs allows one to select optimal building blocks, including metals.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible, Crystalline, and Amorphous Bismuth-Based Metal–Organic Frameworks for Drug Delivery

Orellana-Tavra

Köppen

et al. 2020

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

The synthetic flexibility of metal-organic frameworks (MOFs) with high loading capacities and biocompatibility makes them ideal candidates for drug delivery system (DDS). Here, we report the use of CAU-7, a biocompatible bismuth-based MOF, for the delivery of two cancer drugs, sodium dichloroacetate (DCA) and α-cyano-4-hydroxycinnamic acid (α-CHC). We achieved loadings of 33 and 9 wt.% for DCA and α-CHC, respectively. Interestingly, CAU-7 showed a gradual release of the drugs, achieving time release up to 17 days for DCA and 31 days for α-CHC. We then performed mechanical and thermal amorphization processes to attempt to delay even more the delivery of guest molecules. With the thermal-treatment, we were able to achieve an outstanding 32% slower release of α-CHC from the thermal treated CAU-7. Using in vitro studies and endocytosis inhibitors, confocal microscopy and fluorescence-activated cell sorting (FACS), we also demonstrated that CAU-7 was successfully internalized by cancer cells, partially avoiding lysosome degradation. Finally, we showed that CAU-7 loaded either with DCA or α-CHC had a higher therapeutic efficiency compared with the free drug approach, making CAU-7 a great option for biomedical application.

show abstract

“…Previously, in the literature, there are only five papers which report bismuth-based MOFs having permanent porosity, as demonstrated by nitrogen isotherm experiments. Of these five MOF materials, none have been studied for their use as possible contrast media. − In this manuscript, we report a bismuth cluster MOF, Bi-NU-901, and explore its use as contrast media for X-ray computed tomography (Figure ).…”

Section: Introductionmentioning

confidence: 99%

A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography

Robison

Zhang

Drout

et al. 2019

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

A new bismuth metal−organic framework (MOF), bismuth-NU-901 (Bi-NU-901), featuring the scu topology and a pore with a diameter of ∼11 Å, was solvothermally synthesized, and its use as an X-ray computed tomography (CT) contrast agent was tested. X-ray CT is a common diagnostic method used in the medical field. Inside the body, contrast media enhance the distinction between tissues and organs of similar density. Bi-NU-901 consists of eight connected Bi 6 nodes and tetratopic 1,3,5,8-(p-benzoate)pyrene linkers (TBAPy). Numerous material characterization studies including powder X-ray diffraction (PXRD), scanning transmission electron microscopy (STEM), and DFT pore size distribution support the scu structure. Additionally, given the framework's high density of nontoxic heavy atoms, Bi-NU-901 was evaluated as an X-ray computed tomography (CT) agent. Importantly, in vitro studies revealed this new bismuth MOF demonstrates ∼7 times better contrast intensity compared to a zirconium MOF featuring the same topology and ∼14 times better contrast than a commercially available CT contrast agent. These results suggest bismuth MOFs may be promising CT contrast agents.

show abstract

Solvent-Dependent Formation of Three New Bi-Metal–Organic Frameworks Using a Tetracarboxylic Acid

Cited by 44 publications

References 41 publications

A Robust and Biocompatible Bismuth Ellagate MOF Synthesized Under Green Ambient Conditions

A Robust and Biocompatible Bismuth Ellagate MOF Synthesized Under Green Ambient Conditions

Biocompatible, Crystalline, and Amorphous Bismuth-Based Metal–Organic Frameworks for Drug Delivery

A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography

Contact Info

Product

Resources

About