A Robust and Biocompatible Bismuth Ellagate MOF Synthesized Under Green Ambient Conditions

Abstract

The first bioinspired microporous metal–organic framework (MOF) synthesized using ellagic acid, a common natural antioxidant and polyphenol building unit, is presented. Bi 2 O(H 2 O) 2 (C 14 H 2 O 8 )· n H 2 O (SU-101) was inspired by bismuth phenolate metallodrugs, and could be synthesized entirely from nonhazardous or edible reagents under ambient aqueous conditions, enabling simple scale-up. Reagent-grade and affordable dietary supplement-grade ellagic acid was sourced from tree bark and pomegranate hulls, respectively. Biocompatibility and colloidal stability were confirmed by in vitro assays. The material exhibits remarkable chemical stability for a bioinspired MOF (pH = 2–14, hydrothermal conditions, heated organic solvents, biological media, SO 2 and H 2 S), attributed to the strongly chelating phenolates. A total H 2 S uptake of 15.95 mmol g –1 was recorded, representing one of the highest H 2 S capacities for a MOF, where polysulfides are formed inside the pores of the material. Phenolic phytochemicals remain largely unexplored as linkers for MOF synthesis, opening new avenues to design stable, eco-friendly, scalable, and low-cost MOFs for diverse applications, including drug delivery.

Capture and Separation of SO2 Traces in Metal–Organic Frameworks via Pre‐Synthetic Pore Environment Tailoring by Methyl Groups

“…[15][16][17][18][19][20][21] Among them, MOFs seem most promising due to their outstanding features including reticular synthesis,t unable structure,a nd high porosity. [22][23][24][25] Up to now,t here is still as mall number of MOFs reported for SO 2 adsorption [26][27][28] when compared to CO 2 and CH 4 sorption. Less effort was even given to targeted trace SO 2 removal, that is,h igh SO 2 uptake at low partial pressure.I ng eneral, the capacity of trace SO 2 removal is quantified by the SO 2 uptake amount at apartial pressure of 0.1 bar or even 0.01 bar.…”

Weak Coordination Bond of Chloromethane: A Unique Way to Activate Metal Node Within an Unstable Metal–Organic Framework DUT‐34

“…Metal–organic frameworks (MOFs), which are assembled by the continuous link of coordination bonds between inorganic metal ions (or metal‐oxo clusters) and polydentate organic ligands, are a highly crystalline subset of these fascinating porous materials. With their permanent porosity, exceptionally high internal surface area, wide chemical variety, and tunable topology, MOFs have been examined for their potential in applications such as gas uptake, 1–8 molecular separation, 1,2,9–16 drug delivery, 1,17–20 sensing, 21–25 ion transport, 1,2,26–31 electronic conduction, 1,32–38 among others 39–44 …”

On the completeness of three-dimensional electron diffraction data for structural analysis of metal–organic frameworks

“…Benetting from continuous rotation electron diffraction, a growing number of MOF structures have been determined, with their unique properties revealed. [29][30][31][32][33][34][35][36][37][38] However, the geometric constraints in a TEM impose a physical limitation on the tilt range on the goniometer. Even using a specialized tomography sample holder, 3DED data can be acquired only from À70 to +70 .…”