Solvent assisted bonding of polymethylmethacrylate: Characterization using the response surface methodology

Umbrecht, F.; Müller, Daniel J.; Gattiker, F.; Boutry, Clémentine M.; Neuenschwander, J.; Sennhauser, U.; Hierold, C.

doi:10.1016/j.sna.2009.03.028

Cited by 34 publications

(25 citation statements)

References 27 publications

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“…The deformation percentage of the microchannel in the microfluidic chip (aspect ratio: 0.4) with isopropanol solvent is 2%-6%, and its bonding strength is 0.3 MPa [34]. The deformation percentages of the microchannel in the microfluidic chip (aspect ratio: 0.34 and 0.03) with ethylene glycol dimethacrylate is 1.6 ± 0.3% and 30%, respectively [32]. The bonding strengths with ethanol solvent (aspect ratio: 0.043) are 3.05-8.1 MPa, which are much stronger than those with other solvents or without the solvent bonding reported above.…”

Section: Influence Of Thermal Bonding Parametersmentioning

confidence: 99%

“…For the thermal bonding technique, which can obtain a higher bonding strength, the separation channel for gravitational field flow fractionation has a low depth/width, which is similar to those of microchips [31]. The deformation will remarkably increase with the reduction of the depth/width on the bonding microchips [32]. Although much has been learned about the fabrication of microchips, a cost-effective manufacturing method for gravitational field flow fractionation remains poorly realized.…”

Section: Open Accessmentioning

confidence: 99%

“…Previous studies on the bonding of microfluidic chips revealed that factors, such as the adoption of the solvent and the depth/width (aspect ratio) of chip structure, have a significant influence on the deformation of microchannel [32]. The deformation percentage of the microchannel in the PMMA thermally bonded microfluidic chip in the absence of solvent is 11.9% at a minimum, and its bonding strength is 2.10 MPa at a maximum [33].…”

Section: Influence Of Thermal Bonding Parametersmentioning

confidence: 99%

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Gravitational Field-Flow Fractionation Devices Fabricated via a Hot Embossing/Thermal Bonding Method

Yang

2014

Micromachines

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A novel hot embossing/low temperature ethanol solvent bonding method for the fabrication of polymethylmethacrylate (PMMA) field flow fractionation devices has been developed. The separation channel on a PMMA substrate was generated by a hot embossing process without vacuum. Special temperature-pressure profiles were used to analyze the influence of the hot embossing parameters. After the hot embossing process, ethanol solvent bonding was used to seal the separation channel on the PMMA substrate. The experimental results show that the bonding strength with ethanol solvent bonding at 35 °C (aspect ratio (depth/width): 0.043) is 3.05 MPa, and the deformation percentage is very low (0.54%). A burst pressure test indicated that the as-prepared PMMA gravitational field flow fractionation device has a very high burst pressure. Furthermore, the higher resolution of the as-prepared PMMA gravitational field flow fractionation device in the separation of wheat and starch particles shows that the hot embossing/low temperature ethanol solvent bonding technique will have potential commercial value.

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Section: Influence Of Thermal Bonding Parametersmentioning

confidence: 99%

Section: Open Accessmentioning

confidence: 99%

Section: Influence Of Thermal Bonding Parametersmentioning

confidence: 99%

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Gravitational Field-Flow Fractionation Devices Fabricated via a Hot Embossing/Thermal Bonding Method

Yang

2014

Micromachines

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“…Brown et al increased the hot-press bonding strength to 550 ± 30 N/cm 2 by utilizing the dimethyl sulfoxide (DMSO) miscible solution [28]. In further research of Umbrecht et al, the bonding strength was increased to 780 ± 100 N/cm 2 and the deformation was 9.2 ± 2.3% [31]. Organic solvent can seal the device independently, while the bonding strength declines.…”

Section: Comparison Of Different Bonding Processesmentioning

confidence: 99%

“…However, it is unsatisfactory here due to the possible structural damage caused by overly swelling. To reduce swelling damage, scholars proposed solvent assisted bonding method [28][29][30][31][32]. The organic solvents here are utilized for PMMA surface modification, the modified interface lead to a joint molecule diffusion zone when small pressure is applied on substrates.…”

Section: Introductionmentioning

confidence: 99%

Miscible Organic Solvents Soak Bonding Method Use in a PMMA Multilayer Microfluidic Device

Zhang

Liu

et al. 2014

Micromachines

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Abstract:In this paper, we proposed a novel bonding technology to fabricate a microfluidic device based on Poly(methyl methacrylate) (PMMA). The method, which used chloroform and ethanol as miscible bonding solvent, can complete complex structures rapid assembly (10 min) at 40°C. A bonding strength of 267.5 N/cm 2 can be achieved, while the micro channel deformation was less than 7.26%. Then we utilized this method to produce a three layers micro mixer, which included a T-shaped inlet channel and six H-shaped mixing units. Numerical simulation indicated that, the well mixing length of the mixer was only about 6 mm when Re = 10. Finally, fluorescence microscopy was used to verify mixer performance. The method provided the potential for mass production of multilayer rigid polymer microfluidic devices.

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Microfluidic Devices for Nucleic Acid (NA) Isolation, Isothermal NA Amplification, and Real-Time Detection

Mauk

Liu

Sadik

et al. 2014

Methods in Molecular Biology

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Molecular (nucleic acid)-based diagnostics tests have many advantages over immunoassays, particularly with regard to sensitivity and specificity. Most on-site diagnostic tests, however, are immunoassay-based because conventional nucleic acid-based tests (NATs) require extensive sample processing, trained operators, and specialized equipment. To make NATs more convenient, especially for point-of-care diagnostics and on-site testing, a simple plastic microfluidic cassette ("chip") has been developed for nucleic acid-based testing of blood, other clinical specimens, food, water, and environmental samples. The chip combines nucleic acid isolation by solid-phase extraction; isothermal enzymatic amplification such as LAMP (Loop-mediated AMPlification), NASBA (Nucleic Acid Sequence Based Amplification), and RPA (Recombinase Polymerase Amplification); and real-time optical detection of DNA or RNA analytes. The microfluidic cassette incorporates an embedded nucleic acid binding membrane in the amplification reaction chamber. Target nucleic acids extracted from a lysate are captured on the membrane and amplified at a constant incubation temperature. The amplification product, labeled with a fluorophore reporter, is excited with a LED light source and monitored in situ in real time with a photodiode or a CCD detector (such as available in a smartphone). For blood analysis, a companion filtration device that separates plasma from whole blood to provide cell-free samples for virus and bacterial lysis and nucleic acid testing in the microfluidic chip has also been developed. For HIV virus detection in blood, the microfluidic NAT chip achieves a sensitivity and specificity that are nearly comparable to conventional benchtop protocols using spin columns and thermal cyclers.

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Solvent assisted bonding of polymethylmethacrylate: Characterization using the response surface methodology

Cited by 34 publications

References 27 publications

Gravitational Field-Flow Fractionation Devices Fabricated via a Hot Embossing/Thermal Bonding Method

Gravitational Field-Flow Fractionation Devices Fabricated via a Hot Embossing/Thermal Bonding Method

Miscible Organic Solvents Soak Bonding Method Use in a PMMA Multilayer Microfluidic Device

Microfluidic Devices for Nucleic Acid (NA) Isolation, Isothermal NA Amplification, and Real-Time Detection

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