Miscible Organic Solvents Soak Bonding Method Use in a PMMA Multilayer Microfluidic Device

Zhang, He; Liu, Xiaowei; Li, Tian; Han, Xiaowei

doi:10.3390/mi5041416

Cited by 19 publications

(13 citation statements)

References 33 publications

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“…The two PMMA layers were adhered using chloroform glue 39 . Small volumes (5.0 μ l) of chloroform were dropped into the corners of the device between the top and bottom layers and aligned using an optical microscope, before evaporation of the chloroform, i.e., within 30 s. Adding more than 10 μ l chloroform or adding chloroform near the channels resulted in clogging of the channels.…”

Section: Experimental Methodsmentioning

confidence: 99%

A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

et al. 2016

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This paper proposes a new “twisted” 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices.

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Section: Experimental Methodsmentioning

confidence: 99%

A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

et al. 2016

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“…Ultrasonic cleaning equipment (KQ-5200DB; Kun Shan Ultrasonic Instruments Co., Ltd., Kunshan, China) was used for substrate cleaning. The miscible organic solvents soak bonding method [30] was used to bond the multilayer mixing device. The bonding processes are summarized below.…”

Section: Mixer Design and Manufacturementioning

confidence: 99%

Chaotic Micromixer Based on 3D Horseshoe Transformation

Zhang

Chuai

et al. 2019

Micromachines

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To improve the efficiency of mixing under laminar flow with a low Reynolds number (Re), a novel three-dimensional Horseshoe Transformation (3D HT) was proposed as the basis for the design of a micromixer. Compared with the classical HT, the Lyapunov exponent of the 3D HT, which was calculated based on a symbolic dynamic system, proved the chaotic enhancement. Based on the 3D HT, a micromixer with a mixing length of 12 mm containing six mixing units was obtained by sequentially applying “squeeze”, “stretch”, “twice fold”, “inverse transformation”, and “intersection” operations. Numerical simulation and Peclet Number (Pe) calculations indicated that when the squeeze amplitude 0 < α < 1/2, 0 < β < 1/2, the stretch amplitude γ > 4, and Re ≥ 1, the mass transfer in the mixer was dominated by convective diffusion induced by chaotic flow. When Re = 10, at the outlet of the mixing chamber, the simulated mixing index was 96.4%, which was far less than the value at Re = 0.1 (σ = 0.041). Microscope images of the mixing chamber and the curve trend of pH buffer solutions obtained from a mixing experiment were both consistent with the results of the simulation. When Re = 10, the average mixing index of the pH buffer solutions was 91.75%, which proved the excellent mixing efficiency of the mixer based on the 3D HT.

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“…The microstructure was formed on polymethyl methacrylate (PMMA) with an ultra-precision engraving machine; the electrodes leads were welded and fitted to the cover sheet. The electrodes were bonded to the PMMA via organic solvent immersion [ 19 ]. The gold drive electrode was welded to the PCB, and the PMMA middle layer was bonded to the PCB using modified acrylic adhesive.…”

Section: Sensor and Microfluidic Chip Preparationmentioning

confidence: 99%

Design, Preparation and Performance Study of On-Chip Flow-Through Amperometric Sensors with an Integrated Ag/AgCl Reference Electrode

Zhang

Chuai

et al. 2018

Micromachines

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To improve the reference potential stability of on-chip amperometric sensors, we propose a novel integrated Ag/AgCl reference electrode structure. This structure can refresh the saturated potassium chloride filling solution surrounding the Ag/AgCl electrode. We then designed a flow-through amperometric sensor and a multilayer microfluidic chip based on the integrated reference electrode. In order to improve the detection signal strength of the flow-through sensor, a numerical simulation model was established. The simulation results showed that a combination of (1) using a step-type detection cell structure that maintains micro-channel width while reducing micro-channel height, and (2) controlling the sample flow rate to limit the mass transfer of the sensor surface effectively, improves the detection signal strength. The step-type detection cell structure had dimensions of 200 μm × 200 μm × 100 μm (length × width × height), and the electroosmotic flow driving voltage was 120 V/cm. Finally, successful trace detection of Mg2+ and Pb2+ in the water was achieved using the amperometric sensor and microfluidic chip: detection limits were 5 μmol/L and 84 μmol/L. The preparation of an on-chip flow-through amperometric sensor with an integrated Ag/AgCl reference electrode will facilitate improved portability of microfluidic detection technology.

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Miscible Organic Solvents Soak Bonding Method Use in a PMMA Multilayer Microfluidic Device

Cited by 19 publications

References 33 publications

A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

Chaotic Micromixer Based on 3D Horseshoe Transformation

Design, Preparation and Performance Study of On-Chip Flow-Through Amperometric Sensors with an Integrated Ag/AgCl Reference Electrode

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