Solution synthesis of hydroxyapatite designer particulates

Riman, Richard E.; Suchanek, Wojciech L.; Byrappa, K.; Chen, Chun-Wei; Shuk, P.; Oakes, Charles S.

doi:10.1016/s0167-2738(02)00545-3

Cited by 176 publications

(95 citation statements)

References 19 publications

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“…HA with the Ca/P ratio [1.67 (Ca-rich HA) might be prepared as well (Bonel et al 1988). The detailed information on HA synthesis is available elsewhere (Narasaraju and Phebe 1996; Riman et al 2002;Koutsopoulos 2002;Norton et al 2006;Sadat-Shojai et al 2013). In addition, there are good reviews on HA solubility, crystal growth and intermediate phases of HA crystallization (Rakovan 2002), as well as on HA dissolution (Dorozhkin 2012e).…”

Section: Ha (Or Hap or Ohap)mentioning

confidence: 99%

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Dorozhkin¹

2017

Morphologie

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Section: Ha (Or Hap or Ohap)mentioning

confidence: 99%

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Dorozhkin¹

2017

Morphologie

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“…The latter generally offer lower temperature synthesis than solid-state reactions, from component oxides/carbonates, and common wet chemical routes include: precipitation [13], hydrothermal [14][15][16]. And solgel synthesis [3,17].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Hydrothermal and Sol-Gel Synthesis of Nano-Particulate Hydroxyapatite by Characterisation at the Bulk and Particle Level

Bilton¹,

J.²,

P.³

2012

OJINM

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Hydrothermal and sol-gel synthesis methods have been used to prepare nano-particulate hydroxyapatite (HA) powders for detailed characterisation. Bulk elemental analysis data are compared from X-ray diffraction, X-ray fluorescence and Fourier transform infrared spectroscopy. These show the presence of secondary phases in the sol-gel powders which can be attributed to evaporative loss of precursor phosphite phases during specimen preparation and breakdown of the primary HA phase during calcination. Only the primary HA phase is detected in the hydrothermally prepared powder. In addition, Ca/P ratios of each powder are determined at the particle level using transmission electron microscopy with energy dispersive X-ray spectroscopy (TEM-EDX), having first established a threshold electron fluence below which significant electron-beam-induced alteration of the composition of HA does not occur. The TEM-EDX results show a greater compositional variability of particles from the sol-gel preparation route compared to the hydrothermal route. Overall it is the combination of the analysis techniques that shows the hydrothermal synthesis route produces nearstoichiometric, single phase, hydroxyapatite.

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“…This is further complicated by the fact that all mineralization processes are ultimately controlled by the cells directly associated to the tissue formation [8]. In literatures, nanometer scaled HAP powders and coatings can be synthesized using a number of strategies including sol-gel processing [9], co-precipitation [10,11], emulsion techniques [12], batch hydrothermal processes [13][14][15][16][17], mechano-chemical methods [18] and chemical vapor deposition [19]. However, bio-compatible and environment-friendly pathway to synthesize biocomposites of HAP-biomolecule is also being explored.…”

Section: Introductionmentioning

confidence: 99%

Rapid biomimetic mineralization of chitosan scaffolds with a precursor sacrificed method in ethanol/water mixed solution

Li¹,

Zhao²,

Ding³

et al. 2011

Express Polym. Lett.

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Abstract. Biomimetic mineralization was performed on a large scale by a rapid and efficient approach. Chitosan scaffolds were placed in a mixed solution of urea, ethanol and distilled water, followed by the introduction of dibasic sodium phosphate (0.1M) and calcium chloride (0.1M) with the molar ratio of 1.67. These mixed solvents was then adjusted to weakly alkaline by adding sodium hydroxide solution. Finally the reaction mixture was sealed and kept at 80ºC for predetermined time. The composition and morphology of the apatite and the hybrid scaffolds were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier Transform Infrared spectroscopy (FTIR) and environmental scanning electron microscopy (ESEM). The mechanism of nucleation and growth of crystals was discussed as well. The results revealed that chitosan scaffolds improved the crystallinity of hydroxyapatite (HAP) crystals. With the extension of mineralization time, the mineral layers on the outer surface and inner section of chitosan scaffolds increased as well. Furthermore, the compressive strength and modulus of the HAP-chitosan scaffolds biocomposites increased to 0.55±0.003 and 29.29±1.25 MPa respectively. Such one-pot approach may be extended to the mineralization of other materials and will have a broad application in the future.

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Solution synthesis of hydroxyapatite designer particulates

Cited by 176 publications

References 19 publications

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Comparison of Hydrothermal and Sol-Gel Synthesis of Nano-Particulate Hydroxyapatite by Characterisation at the Bulk and Particle Level

Rapid biomimetic mineralization of chitosan scaffolds with a precursor sacrificed method in ethanol/water mixed solution

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