Soluble αKlotho as a candidate for the biomarker of aging

Koyama, Daisuke; Sato, Yu; Aizawa, Masato; Maki, Takumi; Kurosawa, Masaki; Kuro‐o, Makoto; Furukawa, Yusuke

doi:10.1016/j.bbrc.2015.10.018

Cited by 40 publications

(32 citation statements)

References 43 publications

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“…By contrast plasma 1,25 (OH) 2 contributes to systemic ageing [18]. Plasma levels of FGF23, the ligand of the Klotho-FGFR complex, seem to be independent of age [19].…”

Section: Functional Changes During Ageing | Endocrine Changesmentioning

confidence: 96%

Kidney and aging — A narrative review

Gekle

2017

Experimental Gerontology

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“…By contrast plasma 1,25 (OH) 2 contributes to systemic ageing [18]. Plasma levels of FGF23, the ligand of the Klotho-FGFR complex, seem to be independent of age [19].…”

Section: Functional Changes During Ageing | Endocrine Changesmentioning

confidence: 96%

Kidney and aging — A narrative review

Gekle

2017

Experimental Gerontology

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“…People >60 years old were recruited from among outpatients at Miyashita Hospital between July 2016 and November 2016. All patients lived in Onuma County, in which more than 50% of the residents are elderly (20). A total of 73 patients (58 women and 15 men) agreed to participate in this study, which was approved by the local Ethics Committee at Miyashita Hospital and carried out in accordance with the relevant guidelines and regulations.…”

Section: Methodsmentioning

confidence: 99%

“…These findings have raised the possibility that each endocrine FGF may be associated with aging and thus contribute to age-related diseases in humans. As the first step to explore this possibility, we performed a single-center crosssectional study in a region with a high prevalence of aging (20) and determined whether or not an association exists between the serum levels of endocrine FGFs and clinical parameters relevant to aging and age-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Serum Endocrine Fibroblast Growth Factors as Potential Biomarkers for Chronic Kidney Disease and Various Metabolic Dysfunctions in Aged Patients

et al. 2020

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Objective To prolong the health expectancy, it is important to prevent age-related diseases, such as osteoporosis and cerebrovascular disease, which are major causes of a bedridden state. Early predictable biomarkers for these diseases are urgently required in the clinical setting. Three members of the fibroblast growth factor (FGF) family-FGF19, FGF21, and FGF23-are designated as endocrine FGFs and play crucial roles in various metabolic processes. We tried to clarify the clinical utility of endocrine FGFs as biomarkers for agerelated diseases in elderly patients. Methods We examined the serum endocrine FGF levels and analyzed their association with various clinical parameters in 73 outpatients >60 years old as a single-center cross-sectional study. Results In a multivariable linear regression analysis, FGF19 was associated with ALT, a history of cardiovascular disease, and medication with active vitamin D3. FGF21 was associated with the estimated glomerular filtration rate (eGFR), triglyceride level, and hypertension. FGF23 was associated with the eGFR and the serum levels of 1,25-dihydroxy vitamin D3 and TRACP5b. In addition, a receiver operating characteristics analysis revealed that the measurement of FGF21 and FGF23 was useful for detecting chronic kidney disease (CKD) and its complications, including cardiovascular disease and metabolic bone disorder. Conclusion The measurement of FGF21 and FGF23 may be useful for evaluating CKD and its complications. Using serum endocrine FGFs as biomarkers for age-related conditions may help prevent elderly patients from entering a bedridden state.

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“…32 If Klotho is exogenously administered, the senescence of endothelial cell can be significantly reduced. 34 Sirtuin 1(SIRT1) is also recognized as a key modulator of ageing. 34 Sirtuin 1(SIRT1) is also recognized as a key modulator of ageing.…”

Section: Down-regulation Of Klotho or Sirtuin 1 Expressionmentioning

confidence: 99%

“…33 Interestingly, the levels of Klotho were significantly decreased in old patients (80-89 years) with CKD compared to patients with CKD at the age of 60-69; serum Klotho levels were inversely correlated with age, suggesting that Klotho may serve a biomarker of ageing progression. 34 Sirtuin 1(SIRT1) is also recognized as a key modulator of ageing. SIRT1 can deacetylate histone as well as non-histone proteins such as FOXOs, p53 and NF-κB, 35,36 thereby influencing several important signalling pathways associated with cellular stress, metabolism and longevity.…”

Section: Down-regulation Of Klotho or Sirtuin 1 Expressionmentioning

confidence: 99%

The emerging role of cellular senescence in renal diseases

Zhou

Wan

Chen

et al. 2020

J Cellular Molecular Medi

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Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence prevention, but it is also involved in many cardiovascular, renal and liver diseases through the senescence-associated secretory phenotype (SASP). This review summarizes the molecular mechanisms underlying cellular senescence and its possible effects on a variety of renal diseases. We will also discuss the therapeutic approaches based on the regulation of senescent and SASP blockade, which is considered as a promising strategy for the management of renal diseases. K E Y W O R D Sacute renal injury, cellular senescence, diabetic nephropathy, glomerulonephritis, kidney transplanation, renal diseases, renal fibrosis, senescence-associated secretory phynotype

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Soluble αKlotho as a candidate for the biomarker of aging

Cited by 40 publications

References 43 publications

Kidney and aging — A narrative review

Kidney and aging — A narrative review

Serum Endocrine Fibroblast Growth Factors as Potential Biomarkers for Chronic Kidney Disease and Various Metabolic Dysfunctions in Aged Patients

The emerging role of cellular senescence in renal diseases

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