Kidney and aging — A narrative review

Gekle, Michael

doi:10.1016/j.exger.2016.03.013

Cited by 63 publications

(41 citation statements)

References 22 publications

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“…This result is consistent with the studies of the human kidney [18,34]. It showed that the kidney structure tended to be completed with age, and the function of the kidney gradually increased [7].…”

Section: Discussionsupporting

confidence: 91%

Distribution of EGFR, BMP-2, and p53 in kidney of healthy newborn, adult and old highland-plateau yaks

et al. 2015

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Section: Discussionsupporting

confidence: 91%

Distribution of EGFR, BMP-2, and p53 in kidney of healthy newborn, adult and old highland-plateau yaks

et al. 2015

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“…It is caused by the accumulation of toxins in the internal medium, and the consequence is the development of elderly associated pathologies, mainly CVD [48]. CKD-associated CVD show similar characteristics to the natural CVD in elderly, and for this reason, several authors propose that the biggest challenge in the treatment of CVD may be to understand why CKD promote the premature aging of the cardiovascular system [49].…”

Section: Chronic Kidney Disease a Model Of Chronic Pathology That Acmentioning

confidence: 99%

Endothelial Cell Senescence in the Pathogenesis of Endothelial Dysfunction

Carracedo¹,

Ramírez-Carracedo²,

Alique³

et al. 2018

Endothelial Dysfunction - Old Concepts and New Challenges

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Aging is the main risk factor for cardiovascular diseases (CVD), and senescence in endothelial cells seems to be an initial step in the cascade of events that will culminate with the development of these pathologies. In this chapter, we examine the pathophysiological mechanism(s) involved in endothelial senescence, leading to CVD as well as the biochemical and cellular pathways that may explain the activation and development of the process of endothelial senescence, and we discuss new hypotheses supported by experimental results which suggest that the senescent endothelial cell may induce a general process of vascular senescence. This process is probably induced either by soluble molecules secreted by these senescent cells and/or by intercellular signals transported in cellular vesicles that may be useful as biomarkers and as potential therapeutic targets in endothelial senescence.

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“…Functionality of kidney peaks at about 20 years old, then it suffers a slow but progressive decline . Aging is a biological process associated with transcriptional changes in many genes . Changes at the cellular, molecular and physiological levels have been identified and correlated with aging in some renal diseases .…”

Section: Introductionmentioning

confidence: 99%

Morphological and functional characteristics of aging kidneys based on two‐photon microscopy in vivo

Guo

Horng

et al. 2019

Journal of Biophotonics

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Age-related kidney disease, which is chronic and naturally occurring, is a general term for a set of heterogeneous disorders affecting kidney structures and characterized by a decline in renal function. Age-related renal insufficiency has important implications with regard to body homeostasis, drug toxicity and renal transplantation. In our study, two-photon microscopy was used to image kidney morphological and functional characteristics in an age-related rat model in vivo. The changes in morphology are analyzed based on autofluorescence and Hoechst 33342 labeling in rats with different ages. Structural parameters including renal tubular diameter, cell nuclei density, size and shape are studied and compared with Hematoxylin and Eosin histological analysis. Functional characteristics, such as blood flow, and glomerular filtration rate are studied with high-molecular weight (MW) 500-kDa dextran-fluorescein and low-MW 10-kDa dextran-rhodamine. Results indicate that morphology changes significantly and functional characteristics deteriorate with age. These parameters are potential indicators for evaluating age-related renal morphology and function changes. Combined analyses of these parameters could provide a quantitative, novel method for monitoring kidney diseases and/or therapeutic effects of kidney drugs. K E Y W O R D Sage-related kidney, renal function, renal morphology, two-photon microscopy

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Kidney and aging — A narrative review

Cited by 63 publications

References 22 publications

Distribution of EGFR, BMP-2, and p53 in kidney of healthy newborn, adult and old highland-plateau yaks

Distribution of EGFR, BMP-2, and p53 in kidney of healthy newborn, adult and old highland-plateau yaks

Endothelial Cell Senescence in the Pathogenesis of Endothelial Dysfunction

Morphological and functional characteristics of aging kidneys based on two‐photon microscopy in vivo

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