Endothelial Cell Senescence in the Pathogenesis of Endothelial Dysfunction

Carracedo, Julia; Ramírez-Carracedo, Rafael; Alique, Matilde; Ramírez-Chamond, Rafael

doi:10.5772/intechopen.73024

Cited by 17 publications

(27 citation statements)

References 126 publications

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“…Accordingly, the results of our previous study show that both strands of miR-126 are encapsulated in endothelial MVs, and that vascular endothelial repair is mediated by miR-126 and HIF-1α . Results reported that miRNAs are involved in the senescence phenotype acquisition (Alique et al, 2017Carracedo et al, 2018b). Several miRNAs-mediated pathological effects are described in Table 3.…”

Section: Vsmcs Contractility and Proliferationmentioning

confidence: 99%

Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence

Carracedo

Alique

Vida

et al. 2020

Front. Cell Dev. Biol.

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Cardiovascular diseases (CVDs), especially those involving a systemic inflammatory process such as atherosclerosis, remain the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). CKD is a systemic condition affecting approximately 10% of the general population. The prevalence of CKD has increased over the past decades because of the aging of the population worldwide. Indeed, CVDs in patients with CKD constitute a premature form of CVD observed in the general population. Multiple studies indicate that patients with renal disease undergo accelerated aging, which precipitates the appearance of pathologies, including CVDs, usually associated with advanced age. In this review, we discuss several aspects that characterize CKD-associated CVDs, such as etiopathogenic elements that CKD patients share with the general population, changes in the cellular balance of reactive oxygen species (ROS), and the associated process of cellular senescence. Uremiaassociated aging is linked with numerous changes at the cellular and molecular level. These changes are similar to those observed in the normal process of physiologic aging. We also discuss new perspectives in the study of CKD-associated CVDs and epigenetic alterations in intercellular signaling, mediated by microRNAs and/or extracellular vesicles (EVs), which promote vascular damage and subsequent development of CVD. Understanding the processes and factors involved in accelerated senescence and other abnormal intercellular signaling will identify new therapeutic targets and lead to improved methods of diagnosis and monitoring for patients with CKD-associated CVDs.

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Section: Vsmcs Contractility and Proliferationmentioning

confidence: 99%

Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence

Carracedo

Alique

Vida

et al. 2020

Front. Cell Dev. Biol.

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“…Cellular aging or cellular senescence is a process that occurs naturally in our cells when we age, due to persistent exposure to cellular stressors [11]. Senescent cells are characterized by a permanent state of cell cycle arrest accompanied by a secretory phenotype and resistance to cell death [11]. When a senescent phenotype becomes dysfunctional, the ability to maintain homeostasis between living and dead cells is lost.…”

mentioning

confidence: 99%

“…The current characterization of senescent cells includes the evaluation of molecular senescence markers, such as p53, p21, p16, and γ-H2AX, as well as telomere attrition, which are enhanced signals for senescence-associated beta-galactosidase (SA-β-gal). These markers are indirect indicators because the activation of these pathways is simply one piece of evidence that cells are senescent [11]. Interestingly, once the p16 pathway is activated, senescence arrest cannot be reversed by the inactivation of p53 or the silencing of p16 [16].…”

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confidence: 99%

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Alique

Sánchez-López

Bodega

et al. 2020

Cells

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Aging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy. However, the extension of life is an irreversible process that is accompanied by the development of aging-related conditions such as weakness, slower metabolism, and stiffness of vessels. It also debated that aging can be considered an actual disease with aging-derived comorbidities, including cancer or cardiovascular disease. Currently, cardiovascular disorders, including atherosclerosis, are considered as premature aging and represent the first causes of death in developed countries, accounting for 31% of annual deaths globally. Emerging evidence has identified hypoxia-inducible factor-1α as a critical transcription factor with an essential role in aging-related pathology, in particular, regulating cellular senescence associated with cardiovascular aging. In this review, we will focus on the regulation of senescence mediated by hypoxia-inducible factor-1α in age-related pathologies, with particular emphasis on the crosstalk between endothelial and vascular cells in age-associated atherosclerotic lesions. More specifically, we will focus on the characteristics and mechanisms by which cells within the vascular wall, including endothelial and vascular cells, achieve a senescent phenotype.

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“…Los datos recogidos en la literatura avalan a la senescencia endotelial como uno de los eslabones iniciales de la cadena de eventos que conducen a senescencia y daño vascular, con el subsecuente desarrollo de ECV [76,77]. Dado que las MV endoteliales producidas por células senescentes pueden actuar como mecanismo patogénico en la disfunción endotelial, y puesto que está ampliamente demostrado su papel como sistema de señalización intercelular, era lógico pensar que podían participar promoviendo el daño en otras estructuras vasculares además del propio endotelio [78].…”

Section: Microvesículas Endoteliales Senescentes Como Promotores De La Senescencia Vascularunclassified

El papel del envejecimiento en el desarrollo de enfermedades cardiovasculares asociadas a patologías renales

Aguilar

Bodega

Ramı́rez

et al. 2020

RIECS

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El envejecimiento es considerado un factor de riesgo para el desarrollo de enfermedades cardiovasculares (ECV), y el proceso de senescencia endotelial es el desencadenante de patologías isquémicas y ECV como la arteriosclerosis y la enfermedad renal crónica (ERC). En la senescencia endotelial, las células endoteliales pierden su capacidad de proliferación por el efecto de agentes lesivos como el estrés oxidativo y/o la inflamación generada en el proceso de envejecimiento. Las patologías cardiovasculares, junto al desarrollo de calcificaciones en la pared vascular, presentan una incidencia y prevalencia entre los enfermos con ERC muy superior a la que se observa en la población general. El desarrollo de calcificaciones cardiovasculares es un hallazgo habitual en los enfermos con ERC, sobre todo cuando estos enfermos requieren terapia renal sustitutiva con hemodiálisis (HD). De hecho, entre estos pacientes, las ECV constituyen la principal causa de morbimortalidad, aunque numerosas evidencias indican un carácter plurietiológico para las ECV en los enfermos con ERC. El incremento de estas patologías entre los enfermos en HD sugiere que existen elementos inherentes a la propia HD que actúan como factor patogénico en el desarrollo de las ECV. La caracterización de estos factores para desarrollar elementos de ayuda diagnóstica que permitan identificar enfermos en HD en riesgo de padecer ECV, y desarrollar terapias que eviten el desarrollo de estas patologías es el objetivo de nuestro grupo de investigación.

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Endothelial Cell Senescence in the Pathogenesis of Endothelial Dysfunction

Cited by 17 publications

References 126 publications

Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence

Mechanisms of Cardiovascular Disorders in Patients With Chronic Kidney Disease: A Process Related to Accelerated Senescence

Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

El papel del envejecimiento en el desarrollo de enfermedades cardiovasculares asociadas a patologías renales

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