Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns

Hansen, Anita B.; Verder, Henrik; Staun-Olsen, Poul

doi:10.1515/jpm.2000.012

Cited by 24 publications

(12 citation statements)

References 22 publications

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“…sICAM-1 rose in the peripheral blood of both asphyxiated and infected neonates on the 3rd and 5th postnatal days. Several investigators have found increased sICAM-1 serum levels in septicemic newborns (23,24,(34)(35)(36). To the authors' knowledge, measurements of sICAM-1 in neonatal peripheral blood following perinatal asphyxia have not been reported.…”

Section: Discussionmentioning

confidence: 82%

Inflammatory mediators in perinatal asphyxia and infection

Xanthou¹,

Fotopoulos²,

Mouchtouri³

et al. 2002

Acta Paediatrica

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Xanthou M, Fotopoulos S, Mouchtouri A, Lipsou N, Zika I, Sara dou J. In ammatory mediators in perinatal asphyxia and infection. Acta Paediatr 2002, Suppl 438: 92-97. Stockholm. ISSN 0803-5326 Aim : To determine serum levels of interleukin-6 (IL-6), IL-1 b , tumor necrosis factora (TNFa ), soluble intercellular adhesion molecule-1 (sICAM-1) and C-reactive protein (CRP) in asphyxiated neonates and compare these in ammatory factors with those found in neonates with perinatal infection. Methods: 88 neonates were studied, of whom 36 were asphyxiated, 18 were infected and the remaining 34 were controls. Peripheral blood samples were obtained on the 1st, 3rd and 5th postnatal days. Results: Cytokines IL-6 and IL-1 b as well as sICAM-1 serum levels did not differ between asphyxiated and infected neonates; however, at most time periods, their values were signi cantly higher than controls. TNFa was similar in the three groups of neonates. CRP serum values were signi cantly higher in the infected neonates than in the asphyxiated or control subjects. Among the 54 asphyxiated and infected neonates, 15 were considered as severe cases and 39 as mild. The severe cases, at most time periods, had signi cantly higher IL-6, IL-1 b and sICAM-1 levels compared with the mild ones. Through receiver operating characteristic curves the cut-off points, sensitivities, and speci cities for distinguishing neonates at risk or at high risk for brain damage were established.Conclusion: Similar increases in serum levels of IL-6, IL-1 b and sICAM-1 were found in perinatally asphyxiated and infected neonates. As these increases correlated with the severity of the perinatal insults, neonates at high risk for brain damage might be detected.

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Section: Discussionmentioning

confidence: 82%

Inflammatory mediators in perinatal asphyxia and infection

Xanthou¹,

Fotopoulos²,

Mouchtouri³

et al. 2002

Acta Paediatrica

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“…12 The results show distinctly different patterns of expression of sICAM-1 between premature and fullterm neonates as a function of septic process. Concentrations of sICAM-1 are very high in neonates with sepsis regardless of their gestational age.…”

Section: Discussionmentioning

confidence: 85%

Levels of soluble ICAM‐1 in premature and full‐term neonates with infection

Apostolou¹,

Dimitriou²,

Kaleyias³

et al. 2002

Mediators of Inflammation

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BACKGROUND: Infection in the neonatal period is an extremely serious condition and diagnosis is difficult. C-reactive protein (CRP) is widely used as a marker of infection; however, its usefulness is limited in the early phase. The role of soluble intracellular adhesion molecule-1 (sICAM-1), an adhesion molecule, has been examined in recent studies as an early marker of neonatal infection with controversial results. AIM: Assessment of sICAM-1 concentrations and correlation with CRP, which is the currently used marker of infection, in order to use sICAM as an early diagnostic tool in neonates suspected for infection METHODS: Blood samples and blood cultures were obtained from two groups of pre-term and full-term neonates with clinical suspicion of infection prior to the initiation of antibiotics. The sICAM-1 and CRP values were compared with the corresponding noninfected ones (n = 10 each). RESULTS: The sICAM-1 levels were found increased in the group of both premature and term neonates with infection compared with the corresponding healthy ones (P < 0.0001). Prematurity combined with infection resulted in excessive increase of the levels of sICAM-1 in comparison with full-term infected newborns (p < 0.001). CRP values were normal in all samples except one in both full-term and premature infected neonates on day 1 of clinically suspected infection. Serial detection of CRP values on days 2 and 4 of infection revealed a pattern according to which CRP values in premature neonates continued rising, while in the group of full terms these values, after rising on the second day, lowered on day 4. CONCLUSIONS: Increased sICAM-1 levels can be detected early in both full-term and premature neonates with sepsis while CRP levels are within normal range at the same time. Assessment of sICAM-1 concentrations may be used as a diagnostic tool in neonates suspected for infection, resulting in earlier initiation of antibiotic therapy and therefore improving their outcome.

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“…Total NOS scores range from 0 (lowest) to 9 (highest). According to the NOS scores, the included studies were classified into two levels: low quality (0-6), and high quality (7)(8)(9). Discrepancies in the NOS scores of the included articles were resolved by an additional reviewer through discussion and consultation.…”

Section: Methodsmentioning

confidence: 99%

“…Large quantities of bacteria and viruses may to be associated with infant pneumonia, with viral neonatal pneumonias including intrauterine, early-onset or late-onset pneumonias (6). It has been suggested that C-reactive protein (CRP) may be one of the best single tests for the early detection of pneumonia in children, and could be widely used as marker of infection (8).…”

Section: Introductionmentioning

confidence: 99%

Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis

Xiao

Xue

Sheng

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Experimental data imply that serum C-reactive protein (CRP) is a marker of general systemic inflammation, and inflammation may have a role in the development of pneumonia. The aim of the present study was to investigate the associations of serum CRP levels in infant patients with pneumonia by meta-analysis. The Science Citation Index, Cochrane Library, PubMed, Embase, CINAHL, Current Contents and two Chinese (CMB and CNKI) databases were searched. Studies were pooled and standard mean difference (SMD) and the corresponding 95% confidence interval (CI) were calculated. Subgroup analyses and publication bias detection were also conducted. The statistical analysis was conducted using Stata software version 12.0. Serum CRP levels were analyzed in 10 clinical case-control studies (652 infants with pneumonia and 845 healthy controls); significant differences in serum CRP levels were observed between infants with pneumonia and the healthy controls (SMD=4.41, 95% CI: 3.34-5.47, P<0.001). Ethnicity-stratified subgroup analysis detected that high levels of serum CRP may be the main risk factor for infant pneumonia in Asian, African and Caucasian populations (all P<0.05). Serum CRP levels were statistically higher in infants with pneumonia than in healthy infants, and thus serum levels of CRP may have independent diagnostic value for pneumonia in children.

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Soluble intercellular adhesion molecule and C-reactive protein as early markers of infection in newborns

Cited by 24 publications

References 22 publications

Inflammatory mediators in perinatal asphyxia and infection

Inflammatory mediators in perinatal asphyxia and infection

Levels of soluble ICAM‐1 in premature and full‐term neonates with infection

Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis

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