Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis

Xiao, Xiao; Xue, Long; Sheng, Huilin; Xiao, Zhijian

doi:10.3892/etm.2015.2417

Cited by 9 publications

(4 citation statements)

References 37 publications

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“…It has been suggested that CRP may be one of the best single tests for the early detection of pneumonia in children and could be widely used as marker of infection . The main results of the meta‐analysis by Xiao et al showed that serum CRP levels of newborn infants with pneumonia were higher than those of healthy subjects, suggesting that increasing levels of CRP may indicate pneumonia in newborn infants …”

Section: Introductionmentioning

confidence: 99%

Salivary C‐reactive protein and mean platelet volume in diagnosis of late‐onset neonatal pneumonia

Omran

Ali

Saleh

et al. 2017

Clinical Respiratory J

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Section: Introductionmentioning

confidence: 99%

Salivary C‐reactive protein and mean platelet volume in diagnosis of late‐onset neonatal pneumonia

Omran

Ali

Saleh

et al. 2017

Clinical Respiratory J

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“…In addition, a meta-analysis demonstrated that there were correlations between serum levels of CRP and pneumonia in infants. 37 It has also been reported that serum CRP can be used as a biomarker for evaluating the efficacy of macrolides in macrolide-resistant MPP. 28 In our study, there was no correlation between levels of CRP and IL-17A.…”

Section: Discussionmentioning

confidence: 99%

<p>Clinical Role of Serum Interleukin-17A in the Prediction of Refractory <em>Mycoplasma pneumoniae</em> Pneumonia in Children</p>

Jiu-ling¹,

Ji²,

Wang³

et al. 2020

IDR

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Background: Mycoplasma pneumoniae pneumonia (MPP) is a common community-acquired pneumonia (CAP) in children, which may become refractory MPP (RMPP) to treatment. Objective: The purpose of this study was to evaluate the clinical utility of measuring serum interleukin (IL)-17A to predict RMPP. Patients and Methods: A retrospective clinical study at a single pediatric center included a review of the medical records of all children hospitalized for CAP between November 2015 and October 2019. The diagnosis of MPP was based on clinical presentation, chest radiography, and measurement of serum anti-Mycoplasma immunoglobulin IgM antibody titer using the microparticle agglutination method or sputum samples for Mycoplasma pneumoniae by PCR. Serum levels of IL-18 and IL-17A were determined by ELISA. Results: Of the 625 children diagnosed with CAP, there were 154 children with MPP and without underlying diseases who were divided into a non-refractory MPP (NRMPP) group (n = 109) and a RMPP group (n = 45). The RMPP group had a higher incidence of tachypnea, cyanosis, hypoxia, segmental or lobar pneumonia, pleural effusion, and a longer period of hospitalization compared with NRMPP group (all P-values < 0.05). A serum IL-17A level above 10.8 pg/mL was a predictor for RMPP: area under the curve (AUC) 0.822; standard error (SE) 0.039; 95% confidence interval (CI) 0.746-0.897; diagnostic sensitivity and specificity of 77.8% and 77.1%, respectively. An LDH level above 436.5 IU/L and an IL-18 level above 464.5 pg/mL were the second most useful markers for RMPP: AUC 0.

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“…Several studies have demonstrated a strong association between an increase in CRP levels and the risk of severe pneumonia in children, as shown in one meta-analysis 23 . Elevated CRP levels in pneumonia patients often indicate a more aggressive inflammatory response and a higher burden of infection.…”

Section: Discussionmentioning

confidence: 89%

Viral and bacterial microorganisms in Vietnamese children with severe and non-severe pneumonia

Tran,

Hoang,

Goumballa

et al. 2024

Sci Rep

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To investigate potential respiratory pathogens in children with community-acquired pneumonia (CAP) and risk factors for severe disease. This prospective study was conducted among 467 children at the Thai Binh Paediatric Hospital, Vietnam between 1 July 2020 and 30 June 2021. Clinical data and laboratory results were collected. Twenty-four respiratory microorganisms were tested from nasopharyngeal swabs using real-time PCR. Logistical regression was used to estimate a factor’s adjusted odd ratios of the severity of disease. Mean age of patients = 15.4 ± 13.3 months, 63.0% were male. Over 97% of patients had a positive PCR result. 87% of patients were positive for multiple (up to eight) microorganisms. Rhinovirus (46%), respiratory syncytial virus (RSV) (24%), enterovirus (17%), and parainfluenza viruses-3 (13%) were the most frequent viruses. H. influenzae (61%), S. pneumoniae (45%) and M. catarrhalis (30%) were the most common bacteria. 128 (27%) cases were classified as severe pneumonia. Presence of smokers at home (aOR 2.11, 95% CI 1.27–3.52, P value = 0.004), CRP level ≥ 50 mg/dL (aOR 6.11, 95% CI 3.86–9.68, P value < 0.0001), RSV (aOR 1.78, 95% CI 1.07–2.96, P value = 0.03) and H. influenzae (aOR 1.66, 95% CI 1.03–2.67, P value = 0.04) PCR detection associated with a higher risk of severe pneumonia; ,. Causative agents of pneumonia in children are complex. Children positive with RSV and H. influenzae need to be closely monitored to prevent severe pneumonia.

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Correlation between serum levels of C-reactive protein and infant pneumonia: A meta-analysis

Cited by 9 publications

References 37 publications

Salivary C‐reactive protein and mean platelet volume in diagnosis of late‐onset neonatal pneumonia

Salivary C‐reactive protein and mean platelet volume in diagnosis of late‐onset neonatal pneumonia

<p>Clinical Role of Serum Interleukin-17A in the Prediction of Refractory <em>Mycoplasma pneumoniae</em> Pneumonia in Children</p>

Viral and bacterial microorganisms in Vietnamese children with severe and non-severe pneumonia

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