Solubilizing Potential of Ionic, Zwitterionic and Nonionic Surfactants Towards Water Insoluble Drug Flurbiprofen

"Solubification of NSAIDs in Triton X-5, Triton X-114, and Triton X-100 Micelles"

“…In order to improve the bioavailability of NSAIDs, other researchers used TX-100 and TX-114 micelles with high solubility as solvents. For example, Ullah, et al [8] used spectrophotometry to measure the solubility of flubiprofen in these two micelles and found that both of them could improve the solubility of flubiprofen. In addition, the number of ethylene oxide units in the surfactant plays a key role in the solubilization of meloxicam and celecoxib [9].…”

Formulation of water-dispersible hydrophobic compound nanocomplexes with polypeptides via a supramolecular approach using a high-speed vibration milling technique

“…The development of water solubilization platforms opens the applicability of hydrophobic compounds as pharmaceutical drugs [1][2][3][4][5] and provides eco-friendly methodologies to handle organic dyes without utilizing organic solvents to process organic electrolytes 6,7 and resins 8 in casts. Although surfactants are used as water solubilizers, 9,10 these can contribute to water pollution 11,12 and do harmful damage to ecosystems. 11,12 Therefore, water solubilization techniques have been developed using amphiphilic calixarenes 13 and cyclodextrins (CDxs).…”

Mixed Micelles of Surface Active Ionic Liquid (SAIL)–Octylphenol Ethoxylate: A Novel Reaction Medium for Selective Oxidation of Toluene to Benzaldehyde

“…Solubilization can occur with or without interactions of the surfactant molecules with the solute. Nonionic surfactants which have lower critical micelle concentration (CMC) form larger aggregates and thus solubilization results in a considerably high concentration of the organic solute in the micellar medium (Ullah et al, 2019). Ionic surfactants on the other hand, form smaller micellar aggregates, and also exhibit some sort of interaction with polar solutes.…”