Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35–319.65 K

Abstract

Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, ethyl acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and the λh equation. The experimental solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodynamic properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van’t Hoff equation.

Solubility and thermodynamic functions of deferasirox in different solvents

“…The solubility values of deferasirox dependences on temperature allow a thermodynamic analysis, which permits insight into the molecular mechanism involved in the solution process [28][29]. According to Van't Hoff equation [30], ln S versus 1/T, should be linear and the standard molar enthalpy and entropy changes of dissolution can be determined from its slope and intercept, respectively.…”

Solubility Measurement and Modeling of 4,4′-Dihydroxydiphenyl Sulfone in Nine Organic Solvents from T = (278.15 to 313.15) K and Thermodynamic Property of Dissolution

“…During the experimental process, the solubility of 4,4′-dihydroxydiphenyl sulfone in various solvents were determined by means of the gravimetric method. − The temperature was controlled by using a smart thermostatic water bath with a model of DZKW-4 and a standard uncertainty of 0.02 K. The quantities of the solvent, solute, and saturated liquid were determined by means of an analytical balance with a standard uncertainty of 0.0001 g.…”

Solubility of Phloroglucinol Tris(cyclic 2,2-dimethyl-1,3-propanediol phosphate) in Different Solvents

“…In order to use the solubility data in the temperature range from 288.15 to 318.15 K, the solubility data of PCDMPP in the selected solvents were correlated with the modified Apelblat equation as follows [10,11]:…”