Solubility of Mg-containing β-tricalcium phosphate at 25°C

Li, Xia; Ito, Atsuo; Sogo, Yu; Wang, Xiupeng; LeGeros, Racquel Z.

doi:10.1016/j.actbio.2008.06.010

Cited by 90 publications

(76 citation statements)

References 40 publications

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“…For example, a whitlockite phase is formed on the surface of Mg-TCP. 29) In contrast, the crystal phases of the other filtered powder (¢-TCP, Na-TCP, and K-TCP) were the same as those prior to immersion.…”

Section: Resultsmentioning

confidence: 84%

Dissolution mechanisms of .BETA.-tricalcium phosphate doped with monovalent metal ions

Matsumoto

Yoshida

Hashimoto

et al. 2010

J. Ceram. Soc. Japan

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The effects on solubility of the substitution of monovalent metal ions (Li + , Na + , and K + ions) at the Ca sites in ¢-tricalcium phosphate (¢-TCP) were investigated by immersion of ¢-TCP powder doped with metal ions in saline, and the dissolution mechanisms of these samples were inferred from the results of dissolution tests and from observations of the crystal structures. ¢-TCP powder doped with Li + , Na + , and K + ions (Li-TCP, Na-TCP, and K-TCP) had a lower solubility than pure ¢-TCP powder, and the solubility decreased with an increase in the amount of metal ions. This decrease in solubility can be attributed to an improvement in crystal structure stabilization upon the substitution of monovalent metal ions at the Ca(4) sites and vacancies in ¢-TCP, and the resultant occupancy of Ca 2+ and metal ions at all Ca sites in the ¢-TCP structure. However, the dissolution behavior of Li-TCP differed from that of Na-TCP and K-TCP because the atomic arrangement between the Li(4) sites and oxygen was less stable than that between the Na(4) or K(4) sites and oxygen. In addition, the solubility of ¢-TCP doped with divalent metal ions was lower than that of ¢-TCP doped with monovalent metal ions because the structural stability of ¢-TCP doped with divalent metal ions was higher than that of ¢-TCP doped with monovalent metal ions. These results show that the solubility and dissolution mechanisms of ¢-TCP doped with metal ions were significantly influenced by the crystal structure stabilization and atomic arrangement of doped ¢-TCP.

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Section: Resultsmentioning

confidence: 84%

Dissolution mechanisms of .BETA.-tricalcium phosphate doped with monovalent metal ions

Matsumoto

Yoshida

Hashimoto

et al. 2010

J. Ceram. Soc. Japan

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show abstract

“…A decrease of the average Figure 5, bottom), i.e., for the samples with a higher proportion of -TCP and with a higher Mg content in the -TCP phase. Despite the decrease of the solubility of -TCP when increasing its magnesium content (37), in all of our samples, the Mg-substituted -TCP phase still has a higher solubility than the HAp phase (because the maximal reached substitution corresponds to the Ca 2.751(9) Mg 0.249(9) (PO 4 ) 2 composition). It has been already mentioned that the in vitro bioactivity of HAp leads to the formation of a calcium phosphate layer, which contains a small amount of Mg (38).…”

Section: Resultsmentioning

confidence: 99%

“…The amount of HAp and -TCP in BCP can be tailored by the temperature of calcination (31,32) as well as by the insertion of Mg (2, 10, 21, 33, 34) or Sr (35,36). The dissolution properties of both phases can be modified by the incorporation of doping elements (37). The substitution of Mg during the preparation process of BCP ceramics can also be useful for monitoring the microstructural parameters (namely, the average crystallite size) of HAp and -TCP (10,13,(21)(22)(23)(24)(25)(26)(27).…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization and Biological Fluid Interaction of Sol−Gel-Derived Mg-Substituted Biphasic Calcium Phosphate Ceramics

Gomes

Renaudin

Jallot

et al. 2009

ACS Appl. Mater. Interfaces

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Sol-Gel chemistry has been used to prepare undoped and Mg-substituted biphasic calcium phosphate (BCP) ceramics composed of hydroxyapatite (HAp) and whitlockite ( -TCP) phases. Different series of samples have been synthesized with different Mg-doping levels (from 0 to 5 atomic % of Ca atoms substituted) and different temperatures of calcination (from 500 to 1100°C). All of the powdered samples were systematically treated by Rietveld refinement to extract the quantitative phase analysis and the structural and microstructural parameters, to locate the Mg crystallographic sites, and to refine the composition of the Mg-substituted phases. The temperature dependence of the weight amount ratio between HAp and -TCP is not monotonic because of the formation of minor phases such as Ca 2 P 2 O 7 , CaO, MgO, and CaCO 3 and certainly an amorphous phase. On the other hand, the Mg stabilizing feature on the -TCP phase has been evidenced and explained. The mechanism of stabilization by small Mg 2+ is different from that by large Sr 2+ . Nevertheless, in both cases, the -TCP stabilization is realized by an improvement of the environment of the Ca4 site unusually face-coordinated to a PO 4 tetrahedron. The substitution of a Mg atom in the Ca5 site allows considerable improvement of the bond valence sum of the unusual Ca4 polyhedron. The temperatures of calcination combined with the amount of Mg atoms introduced allow monitoring of the phase composition of the BCP ceramics as well as their microstructural properties. The bioactivity properties of the BCP samples are improved by the presence of Mg atoms in the structure of the -TCP phase. The mechanism of improvement is mainly attributed to an accelerated kinetic of precipitation of a calcium phosphate layer at the surface comprising HAp and/or -TCP phases.

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“…The effect of Mg on decreasing the equilibrium solubility of MgTCP has been substantiated [35,36] and macrophages [37,38]. Thus, the relative dissolution rate may be useful when material-mediated differences in biological process are negligible.…”

Section: Discussionmentioning

confidence: 95%

Interlaboratory studies on in vitro test methods for estimating in vivo resorption of calcium phosphate ceramics

et al. 2015

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Solubility of Mg-containing β-tricalcium phosphate at 25°C

Cited by 90 publications

References 40 publications

Dissolution mechanisms of .BETA.-tricalcium phosphate doped with monovalent metal ions

Dissolution mechanisms of .BETA.-tricalcium phosphate doped with monovalent metal ions

Structural Characterization and Biological Fluid Interaction of Sol−Gel-Derived Mg-Substituted Biphasic Calcium Phosphate Ceramics

Interlaboratory studies on in vitro test methods for estimating in vivo resorption of calcium phosphate ceramics

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