Solubility of 3-Ethyl-5-methyl-(4<i>RS</i>)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate Monobenzenesulfonate (Amlodipine Besylate) in Ethanol + Water and Propane-1,2-diol + Water Mixtures at Various Temperatures

Sardari, Faroukh; Jouyban, Abolghasem

doi:10.1021/je3005672

Cited by 20 publications

(15 citation statements)

References 26 publications

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“…[48][49][50] For instance, the presence of such hydration shells has been reported to result in solubility maxima for drug molecules in ethanol/water mixtures with certain ratios. [51,52] Benefiting from the non-ideal solvent mixture and its large change in polarity with varying temperatures, thermoresponsive polymers with UCST behavior A c c e p t e d M a n u s c r i p t have been developed for which the transition temperature depends on the structure of the alcohol and the composition of the alcohol/water binary solvent. Such UCST systems with low toxicity solvents have promising potential for, e.g., personal care, medical or pharmaceutical applications.…”

Section: Introductionmentioning

confidence: 99%

Polymers with upper critical solution temperature behavior in alcohol/water solvent mixtures

Zhang

Hoogenboom

2015

Progress in Polymer Science

187

164

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Section: Introductionmentioning

confidence: 99%

Polymers with upper critical solution temperature behavior in alcohol/water solvent mixtures

Zhang

Hoogenboom

2015

Progress in Polymer Science

187

164

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“…C Sat 1 and C Sat 2 , at temperature of interest. This hypothesis has been successfully examined in earlier works [31][32][33][34] and provides a practical method to predict the solubility in mixed solvents at various temperatures using minimum experimental efforts.…”

Section: Theoretical Basementioning

confidence: 99%

Naproxen solubility in binary and ternary solvents of polyethylene glycols 200, 400 or 600 with ethanol and water at 298.2 K – experimental data report and modelling

Soltanpour

Shekarriz

2015

Physics and Chemistry of Liquids

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The solubilities of naproxen in the binary and ternary mixtures of polyethylene glycols 200, 400 or 600 with ethanol and water (185 data points) at 298.2 K are determined and mathematically represented by cosolvency models. The obtained overall mean relative deviations (OMRDs) for fitting the solubility data of naproxen in binary and ternary mixtures using Williams-Amidon and Jouyban-Acree model are 15.7% and 16.5%, respectively, and the OMRD values for predicting the solubility data of naproxen by the trained versions of Williams-Amison and Jouyban-Acree models are 71.1% and 64.4%, respectively.

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“…The combination version of the Jouyban–Acree and van’t Hoff models proposed by A. Jouyban and W. E. Acree Jr . was used to correlate the solubility data of trehalose in the binary water + methanol solvent system at different temperatures, and its expression can be written as follows, − where x 1 is the mole fraction of water in mixed solvent, in solute-free basis, x A is the calculated solubility of trehalose in mole fraction according to the selected model, A 1 , B 1 , A 2 , B 2 , J 0 , J 1 , and J 2 terms are the model parameters obtained by nonlinear surface fit of the solubility at different temperatures and water content.…”

Section: Experimental Sectionmentioning

confidence: 99%

Solubility of Trehalose in Water + Methanol Solvent System from (293.15 to 313.15) K

Jiang

et al. 2014

J. Chem. Eng. Data

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The solubility of trehalose in the water + methanol solvent system was measured with the mole fraction of water ranging from 0.000 to 0.700, at temperatures from (293.15 to 313.15) K, using the gravimetric method. Two kinds of crystals were collected and measured by differential scanning calorimetry and X-ray diffraction to prove the change of crystal habit for dihydrate trehalose from granular to powderlike at low water content. The turning points of every solubility curve were the critical points of crystal habit transition from the granular dihydrate trehalose (higher than the critical points) to the powderlike dihydrate trehalose (lower than the critical points). The mole fraction of the critical water content ranged from 0.160 to 0.250. The combination version of the Jouyban−Acree and van't Hoff models was used to separately correlate the solubility data lower and higher than the critical points by nonlinear surface fit. The root-mean-square deviation (rmsd) values for the powderlike and the granular dihydrate trehalose solubility data were 1.4900·10 −4 and 3.5919·10 −4 , respectively, which shows the model correlated the data well. ■ INTRODUCTIONTrehalose, a nonreducing disaccharide which is widespread in plants, animals and microbes, is formed by two glucose units linked in an α,α-1,1-glycosidic linkage. 1 Depending on the given thermodynamic conditions, trehalose mainly has two kinds of polymorphs: dihydrate and anhydrous forms. 2 The dihydrate trehalose can be easily obtained by crystallization from supersaturated solutions and is the most stable one. There are four different forms of anhydrous trehalose reported until now. 3 The β-form which is stable at room temperature and less hydroscopic has been obtained when keeping the dihydrate trehalose under vacuum at 130°C for 4 h, 4 or from the transformation of dihydrate trehalose to anhydrous trehalose using ethanol. 3,5,6 The α-form which could be easily rehydrated back to dihydrate trehalose has been observed when keeping the dihydrate trehalose under vacuum at 85°C for 4 h. 4 The γ-form, the mixture of dihydrate and β-form trehalose, has been shown by the shape of the calorimetric curve for the dihydrate trehalose at 5 K·min −1 to 20 K·min −1 . 4 The ε-form has been obtained still by thermal treatment according to Sussich's report. 7 The importance of observing polymorphic forms and solvated varieties has been recognized by most academic and industrial research groups. 8 In our previous work, we determined the solubility of trehalose in a water + ethanol solvent system, and a white flocculent suspension which is the anhydrous form was observed in low water content. Most researches simply involve water + methanol solvents and water + ethanol solvents to determine the solubility results. 9 So it is necessary to determine the solubility of trehalose in the water + methanol solvent system.In this work, the solubility of trehalose in the water + methanol solvent system was measured with the mole fraction of water ranging from 0.000 to 0.700, at temperatures ...

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Solubility of 3-Ethyl-5-methyl-(4RS)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate Monobenzenesulfonate (Amlodipine Besylate) in Ethanol + Water and Propane-1,2-diol + Water Mixtures at Various Temperatures

Cited by 20 publications

References 26 publications

Polymers with upper critical solution temperature behavior in alcohol/water solvent mixtures

Polymers with upper critical solution temperature behavior in alcohol/water solvent mixtures

Naproxen solubility in binary and ternary solvents of polyethylene glycols 200, 400 or 600 with ethanol and water at 298.2 K – experimental data report and modelling

Solubility of Trehalose in Water + Methanol Solvent System from (293.15 to 313.15) K

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