Solubility measurement and RESOLV-assisted nanonization of gambogic acid in supercritical carbon dioxide for cancer therapy

Xiang, Shuting; Chen, Biao‐Qi; Kankala, Ranjith Kumar; Wang, Shibin; Chen, Ai-Zheng

doi:10.1016/j.supflu.2019.04.008

Cited by 38 publications

(11 citation statements)

References 46 publications

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“…Knez et al, [381] 6. Kankala et al, [349] hinders the accumulation of particles at the expansion jet and considerably ensures the constancy and scattering of the product, which come about within the broad utility of the RESOLV process in planning steady suspensions with well-dispersed and uniform-sized nanoparticles [348]. Gambogic acid (GA) has poor solubility in water.…”

Section: Role(s) Of Sc-co 2 Authors Referencesmentioning

confidence: 99%

Solubility, Extraction, and Nanoparticles Production in Supercritical Carbon Dioxide: A Mini‐Review

Sodeifian

Usefi

2022

ChemBioEng Reviews

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Supercritical carbon dioxide (SC‐CO2) is CO2 that is stored beyond its critical point of 7.4 MPa and 31.1 °C. Given the request for consumption of a green solvent for the environment, SC‐CO2 is widely utilized in chemical, food, and pharmaceutical industries. To design material and drug production processes using supercritical fluid (SCF) technology, knowledge of their solubility is important. Temperature and pressure are the main factors in the study of solubility. Solubility data are then evaluated using equation of state, semi‐empirical, and intelligence models to establish suitable correlations. SC‐CO2 is one of the most important materials used in SCFs to study solubility. Another application of SC‐CO2 is in the field of material extraction to reduce the consumption of organic solvents. Nanoparticles production in drug industry is another advantage of SC‐CO2. Micro and nanoparticles can be produced using SCF techniques. In this review, the applications of SC‐CO2 in drug solubility, extraction of valuable materials, and nanoparticles production for pharmaceutical processes are reported and discussed. Finally, the main challenges are explained.

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Section: Role(s) Of Sc-co 2 Authors Referencesmentioning

confidence: 99%

Solubility, Extraction, and Nanoparticles Production in Supercritical Carbon Dioxide: A Mini‐Review

Sodeifian

Usefi

2022

ChemBioEng Reviews

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“…The polymer excipient then precipitated around the drug, producing core-shell structured microparticles [45]. Another process modification involved the rapid expansion of a supercritical solution into a liquid solvent (RESOLV) in order to obtain nanoscale particles [46,47]. In this case, however, the supercritical solution was expanded into a liquid solvent instead of a lower pressure precipitation chamber, and particles with a diameter less than 50 nm were obtained [46].…”

Section: Rapid Expansion Of Supercritical Solvent (Ress)mentioning

confidence: 99%

Solid Dosage Forms of Biopharmaceuticals in Drug Delivery Systems Using Sustainable Strategies

et al. 2021

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Drug delivery systems (DDS) often comprise biopharmaceuticals in aqueous form, making them susceptible to physical and chemical degradation, and therefore requiring low temperature storage in cold supply and distribution chains. Freeze-drying, spray-drying, and spray-freeze-drying are some of the techniques used to convert biopharmaceuticals-loaded DDS from aqueous to solid dosage forms. However, the risk exists that shear and heat stress during processing may provoke DDS damage and efficacy loss. Supercritical fluids (SCF), specifically, supercritical carbon dioxide (scCO2), is a sustainable alternative to common techniques. Due to its moderately critical and tunable properties and thermodynamic behavior, scCO2 has aroused scientific and industrial interest. Therefore, this article reviews scCO2-based techniques used over the year in the production of solid biopharmaceutical dosage forms. Looking particularly at the use of scCO2 in each of its potential roles—as a solvent, co-solvent, anti-solvent, or co-solute. It ends with a comparison between the compound’s stability using supercritical CO2-assisted atomization/spray-drying and conventional drying.

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“…Recently, Nasri [ 61 ] have presented a different way to estimate

, which is based on obtaining the two parameters

and

of the Clausius-Clapeyron equation given by Equation (12) below [ 62 ]. This requires three steps: first, checking the consistency of the solubility data; second, correlating the data by the model of Mendez-Santiago-Teja [ 63 ] to have

; third, correlating the data by the Bartle’s model [ 64 ] to obtain parameter

, which represents the sublimation enthalpy

[ 65 , 66 , 67 , 68 , 69 , 70 ].…”

Section: Use Of New Sublimation Pressurementioning

confidence: 99%

Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited

Nasri¹

2021

Antibiotics

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Development of processes using green solvents as supercritical fluids (SCFs) depends on the accuracy of modeling and predicting phase equilibrium which is of considerable importance to exploit the use of SCF process at the level of pharmaceutical industries. Solid-Fluid equilibrium modeling is associated to many drawbacks when compressed gas-based models as cubic equations of states (cEoSs) are used. The unavailability of experimental values of solute’s sublimation pressure presents one of the major obstacles to the solubility modeling with this type of models, and thus, its estimation is essential and inevitable. This work is an attempt to address a question regarding “accurate estimated value” of sublimation pressure of two antibiotics Penicillin G (benzyl penicillin) and Penicillin V (phenoxymethyl penicillin). Toward that, first, cEoSs are provided as the thermodynamics modeling framework and fundamental approach. Second, a discussion and a review of some literature results are given. Third, results are invoked to present a criticism analysis that comes from the use of modified form of Peng-Robinson (PR) equation of states. Finally, considerable improvement of modeling results by using a new sublimation pressure is shown.

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Solubility measurement and RESOLV-assisted nanonization of gambogic acid in supercritical carbon dioxide for cancer therapy

Cited by 38 publications

References 46 publications

Solubility, Extraction, and Nanoparticles Production in Supercritical Carbon Dioxide: A Mini‐Review

Solubility, Extraction, and Nanoparticles Production in Supercritical Carbon Dioxide: A Mini‐Review

Solid Dosage Forms of Biopharmaceuticals in Drug Delivery Systems Using Sustainable Strategies

Penicillins’ Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited

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