Supercritical carbon dioxide (SC‐CO2) is CO2 that is stored beyond its critical point of 7.4 MPa and 31.1 °C. Given the request for consumption of a green solvent for the environment, SC‐CO2 is widely utilized in chemical, food, and pharmaceutical industries. To design material and drug production processes using supercritical fluid (SCF) technology, knowledge of their solubility is important. Temperature and pressure are the main factors in the study of solubility. Solubility data are then evaluated using equation of state, semi‐empirical, and intelligence models to establish suitable correlations. SC‐CO2 is one of the most important materials used in SCFs to study solubility. Another application of SC‐CO2 is in the field of material extraction to reduce the consumption of organic solvents. Nanoparticles production in drug industry is another advantage of SC‐CO2. Micro and nanoparticles can be produced using SCF techniques. In this review, the applications of SC‐CO2 in drug solubility, extraction of valuable materials, and nanoparticles production for pharmaceutical processes are reported and discussed. Finally, the main challenges are explained.

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Increasing populations and urbanization put a lot of pressure on freshwater supplies and use. The increased demand for drinking water can be met by using seawater as a source of freshwater. Desalination and wastewater treatment have been energy-and time-consuming processes in recent years. Microbial desalination cells (MDCs) have gained considerable attention as an emerging technology because of their ability to treat wastewater, desalinate seawater, and produce electricity and value-added products. The efficiency and performance of this technology are affected by numerous factors. In this study, the effect of membranes on the efficiency and performance of this technology is examined. Anionic and cationic, carbon nanotube (CNT), bipolar and osmotic membranes were investigated. Anionic and cationic membranes, as well as their modifications, significantly influence microbial desalination cells.CNT-based membranes have shown significant improvements in water permeability, desalination capacity, strength, anti-fouling, and energy efficiency compared to other membranes. Bipolar membranes prevent the pH of the anode chamber from decreasing, which is essential for MDC operation. The use of FO membranes in microbial desalination cells still faces challenges; for instance, fouling is more likely in FO membranes than ion-exchange membranes, resulting in higher internal resistance and decreased water flux. MDC technology will require research into membrane fouling, electron transfer kinetics, material feasibility, microbial growth, and catalyst durability to be scaled and sustainable. As part of the feasibility study, the performance and stability of the reactor must also be examined.