Solubility and solution thermodynamics of raloxifene hydrochloride in various (DMSO + water) compositions

Alyamani, Mohammad; Alshehri, Sultan; Alam, Prawez; Wani, Shahid Ud Din; Ghoneim, Mohammed M.; Shakeel, Faiyaz

doi:10.1016/j.aej.2022.02.051

Cited by 12 publications

(30 citation statements)

References 33 publications

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“…The Yaws model, eq , is a semi-empirical mathematical equation that can correlate the temperature and the solubility and is derived as follows where A , B , and C are the model parameters and are noted in Table S2. ln nobreak0em.25em⁡ x Yaws = A + B T + C T 2 …”

Section: Resultsmentioning

confidence: 99%

Solubility and Thermodynamics Profile of Benzethonium Chloride in Pure and Binary Solvents at Different Temperatures

et al. 2023

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Benzethonium chloride (BTC) has various applications in several industries. The solubility and solution thermodynamic properties of BTC were measured. The solubility of BTC in methanol, ethanol, 1-propanol, 2-propanol, 1butanol, water, dimethyl sulfoxide, acetic acid, and dimethyl formamide neat solvents and methanol + water and ethanol + water binary solvents at 298.15−318.15 K over an atmospheric pressure was measured. The solubility data of BTC is positively related to the temperature in all selected solvents. The solubility data was fitted by the Apelblat model, λh model, Yaws model, Van't Hoff equation, CNIBS/R-K model, and modified Jouyban−Acree equation. The RMSD and ARD were chosen to evaluate the fitting of each model. The dissolution thermodynamic parameters, enthalpy of the solution, entropy of the solution, and Gibbs energy of the solution were calculated. The solubility data and dissolution thermodynamic parameters of BTC will provide significant guidance for purification, crystallization, and separation in various areas.

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Section: Resultsmentioning

confidence: 99%

Solubility and Thermodynamics Profile of Benzethonium Chloride in Pure and Binary Solvents at Different Temperatures

et al. 2023

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“…This study used AlamarBlue® Assay to assess the cytotoxicity effects of different concentrations of ZnO NP on cancer and normal cells using well established protocol (Alyamani et al, 2022; Aslantürk, 2018; Khokhlova et al, 2019; Shokrzadeh & Modanloo, 2017; Tedesco et al, 2018; Ugiyadi et al, 2014; Vembadi et al, 2019; Zachari et al, 2014). In this study, HCT 116 cancer cells and normal Vero cell lines were cultured using established methods to evaluate the cytotoxic properties of different concentrations of zinc oxide nanoparticles (ZnO NPs), having 3000, 1500, 750, 375, and 187.5 μg/mL, derived from pumpkin seeds.…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the cytotoxicity, antioxidant activity, and molecular docking of biogenic zinc oxide nanoparticles derived from pumpkin seeds

Kadir,

Murugan,

Khan

et al. 2023

Microscopy Res & Technique

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This study aimed to investigate the characterization of zinc oxide nanoparticles (ZnONPs) produced from Cucurbita pepo L. (pumpkin seeds) and their selective cytotoxic effectiveness on human colon cancer cells (HCT 116) and African Green Monkey Kidney, Vero cells. The study also investigated the antioxidant activity of ZnONPs. The study also examined ZnONPs' antioxidant properties. This was motivated by the limited research on the comparative cytotoxic effects of ZnO NPs on normal and HCT116 cells. The ZnO NPs were characterized using Fourier‐transform infrared spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Transmission Electron Microscope/Selected Area Electron Diffraction (TEM/SAED), and Scanning Electron Microscope‐Energy Dispersive X‐ray (SEM–EDX) for determination of chemical fingerprinting, heat stability, size, and morphology of the elements, respectively. Based on the results, ZnO NPs from pumpkins were found to be less than 5 μm and agglomerates in nature. Furthermore, the ZnO NPs fingerprinting and SEM–EDX element analysis were similar to previous literature, suggesting the sample was proven as ZnO NPs. The ZnO NPs also stable at a temperature of 380°C indicating that the green material is quite robust at 60–400°C. The cell viability of Vero cells and HCT 116 cell line were measured at two different time points (24 and 48 h) to assess the cytotoxicity effects of ZnO NP on these cells using AlamarBlue assay. Cytotoxic results have shown that ZnO NPs did not inhibit Vero cells but were slightly toxic to cancer cells, with a dose–response curve IC50 = ~409.7 μg/mL. This green synthesis of ZnO NPs was found to be non‐toxic to normal cells but has a slight cytotoxicity effect on HCT 116 cells. A theoretical study used molecular docking to investigate nanoparticle interaction with cyclin‐dependent kinase 2 (CDK2), exploring its mechanism in inhibiting CDK2's role in cancer. Further study should be carried out to determine suitable concentrations for cytotoxicity studies. Additionally, DPPH has a significant antioxidant capacity, with an IC50 of 142.857 μg/mL.Research Highlights Pumpkin seed extracts facilitated a rapid, high‐yielding, and environmentally friendly synthesis of ZnO nanoparticles. Spectrophotometric analysis was used to investigate the optical properties, scalability, size, shape, dispersity, and stability of ZnO NPs. The cytotoxicity of ZnO NPs on Vero and HCT 116 cells was assessed, showing no inhibition of Vero cells and cytotoxicity of cancer cells. The DPPH assay was also used to investigate the antioxidant potential of biogenic nanoparticles. A molecular docking study was performed to investigate the interaction of ZnO NPs with CDK2 and to explore the mechanism by which they inhibit CDK2's role in cancer.

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“…The mass percentage of PEG 400 varied by 0.10 in a number of {PEG 400 (1) + H 2 O (2)} mixes, ranging from 0.10–0.90. Each {PEG 400 (1) + H 2 O (2)} mixture was taken in triplicate [ 31 ]. Utilizing an isothermal method [ 41 ], the mole fraction solubility of FXT against mass fraction of PEG 400 ( m = 0.0 − 1.0; m is the mass fraction of PEG 400 in {PEG 400 (1) + H 2 O (2)} mixtures) in binary {PEG 400 (1) + H 2 O (2)} mixtures) and neat PEG 400 and H 2 O was determined at 298.2-318.2 K and 101.1 kPa.…”

Section: Methodsmentioning

confidence: 99%

“…As a consequence, the cosolvency approach using polyethylene glycol 400 (PEG 400) as a cosolvent was used to enhance the solubility of FXT in this study. The solubility data of pharmaceutical compounds are a significant physicochemical feature for a variety of industrial activities, such as purification, manufacturing, formulation development, and other applications [ 29 , 30 , 31 ]. There is little information on FXT solubilization in mixtures of H 2 O and a cosolvent.…”

Section: Introductionmentioning

confidence: 99%

Solubility and Thermodynamic Properties of Febuxostat in Various (PEG 400 + Water) Mixtures

et al. 2022

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The solubility of the poorly soluble medicine febuxostat (FXT) (3) in various {polyethylene glycol 400 (PEG 400) (1) + water (H2O) (2)} mixtures has been examined at 298.2–318.2 K and 101.1 kPa. FXT solubility was measured using an isothermal method and correlated with “van’t Hoff, Apelblat, Buchowski–Ksiazczak λh, Yalkowsky–Roseman, Jouyban–Acree, and Jouyban–Acree-van’t Hoff models”. FXT mole fraction solubility was enhanced via an increase in temperature and PEG 400 mass fraction in {(PEG 400 (1) + H2O (2)} mixtures. Neat PEG 400 showed the highest mole fraction solubility of FXT (3.11 × 10–2 at 318.2 K), while neat H2O had the lowest (1.91 × 10–7 at 298.2 K). The overall error value was less than 6.0 % for each computational model, indicating good correlations. Based on the positive values of apparent standard enthalpies (46.72–70.30 kJ mol−1) and apparent standard entropies (106.4–118.5 J mol−1 K−1), the dissolution of FXT was “endothermic and entropy-driven” in all {PEG 400 (1) + H2O (2)} mixtures examined. The main mechanism for FXT solvation in {PEG 400 (1) + H2O (2)} mixtures was discovered to be an enthalpy-driven process. In comparison to FXT-H2O, FXT-PEG 400 showed the strongest molecular interactions. In conclusion, these results suggested that PEG 400 has considerable potential for solubilizing a poorly soluble FXT in H2O.

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Solubility and solution thermodynamics of raloxifene hydrochloride in various (DMSO + water) compositions

Cited by 12 publications

References 33 publications

Solubility and Thermodynamics Profile of Benzethonium Chloride in Pure and Binary Solvents at Different Temperatures

Solubility and Thermodynamics Profile of Benzethonium Chloride in Pure and Binary Solvents at Different Temperatures

Evaluation of the cytotoxicity, antioxidant activity, and molecular docking of biogenic zinc oxide nanoparticles derived from pumpkin seeds

Solubility and Thermodynamic Properties of Febuxostat in Various (PEG 400 + Water) Mixtures

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