In the present work, the solubility parameters of the local anesthetic drug bupivacaine hydrochloride (BH) were measured. The pure solvents under study were methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, dimethylformamide (DMF), acetic acid, and water. Two binary solvent systems, namely, methanol + water and ethanol + water, were also used to determine the solubility. The experimental solubility of the BH was obtained by the gravimetric method over a series of temperatures (293.15−333.15 K) in different mono and binary solvents under atmospheric pressure. Experimental results reveal the dependence of solubility on temperature. The experimental mole fraction solubility was further correlated with theoretical models such as the Apelblat, λh, Van't Hoff, modified Jouyban−Acree, and CNIBS/R−K models. The small values of RAD and RMSD indicated that the data are in good agreement with experimental data. The data of solubility can be applied in the fields of production, purification, crystallization, and separation of BH.

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Benzethonium chloride (BTC) has various applications in several industries. The solubility and solution thermodynamic properties of BTC were measured. The solubility of BTC in methanol, ethanol, 1-propanol, 2-propanol, 1butanol, water, dimethyl sulfoxide, acetic acid, and dimethyl formamide neat solvents and methanol + water and ethanol + water binary solvents at 298.15−318.15 K over an atmospheric pressure was measured. The solubility data of BTC is positively related to the temperature in all selected solvents. The solubility data was fitted by the Apelblat model, λh model, Yaws model, Van't Hoff equation, CNIBS/R-K model, and modified Jouyban−Acree equation. The RMSD and ARD were chosen to evaluate the fitting of each model. The dissolution thermodynamic parameters, enthalpy of the solution, entropy of the solution, and Gibbs energy of the solution were calculated. The solubility data and dissolution thermodynamic parameters of BTC will provide significant guidance for purification, crystallization, and separation in various areas.

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