Solubility and Solubilization Approaches in Pharmaceutical Product Development

Acharya, Pratap Chandra; Fernandes, Clara; Suares, Divya; Shetty, Saritha; Tekade, Rakesh K.

doi:10.1016/b978-0-12-814423-7.00015-0

Cited by 5 publications

(2 citation statements)

References 176 publications

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“…Solubility can also be enhanced by reducing the drug’s MW. Smaller-sized lipophilic drugs (e.g., itraconazole, efavirenz) and hydrophilic agents (e.g., mannitol) are preferably absorbed through the tight junctions in-between epithelial cells [ 49 , 52 , 81 , 82 ].…”

Section: Vaginal Drug Delivery Systems: History and Present Therapeuticsmentioning

confidence: 99%

Application of Sol–Gels for Treatment of Gynaecological Conditions—Physiological Perspectives and Emerging Concepts in Intravaginal Drug Delivery

Thapa

Gurung

Parat

et al. 2022

Gels

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Approaches for effective and sustained drug delivery to the female reproductive tract (FRT) for treating a range of gynaecological conditions remain limited. The development of versatile delivery platforms, such as soluble gels (sol–gels) coupled with applicators/devices, holds considerable therapeutic potential for gynaecological conditions. Sol–gel systems, which undergo solution-to-gel transition, triggered by physiological conditions such as changes in temperature, pH, or ion composition, offer advantages of both solution- and gel-based drug formulations. Furthermore, they have potential to be used as a suitable drug delivery vehicle for other novel drug formulations, including micro- and nano-particulate systems, enabling the delivery of drug molecules of diverse physicochemical character. We provide an anatomical and physiological perspective of the significant challenges and opportunities in attaining optimal drug delivery to the upper and lower FRT. Discussion then focuses on attributes of sol–gels that can vastly improve the treatment of gynaecological conditions. The review concludes by showcasing recent advances in vaginal formulation design, and proposes novel formulation strategies enabling the infusion of a wide range of therapeutics into sol–gels, paving the way for patient-friendly treatment regimens for acute and chronic FRT-related conditions such as bacterial/viral infection control (e.g., STDs), contraception, hormone replacement therapy (HRT), infertility, and cancer.

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Section: Vaginal Drug Delivery Systems: History and Present Therapeuticsmentioning

confidence: 99%

Application of Sol–Gels for Treatment of Gynaecological Conditions—Physiological Perspectives and Emerging Concepts in Intravaginal Drug Delivery

Thapa

Gurung

Parat

et al. 2022

Gels

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“…Then the contents were kept with continuous stirring for 8 hours in a water thermostat maintained at the required temperature as described elsewhere [8]. The solution was then filtered and its concentration was determined by titration with standard NaOH solution using phenolphthalein indicator.…”

Section: Chemicalsmentioning

confidence: 99%

An environmental remediation: study of molecular interactions of the poorly soluble pharmaceutical drug ibuprofen in aqueous media

2020

Biointerface Res Appl Chem

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Medication disposal today is an alarming issue and gaining much more awareness from the consumers as well as healthcare professionals. Various molecular interactions surviving in aqueous drug systems may be considered responsible for these health hazards. This paper reports an experimental study of the various physico-chemical properties of poorly water soluble drug, ibuprofen in aqueous system. Conductance of ibuprofen been measured in aqueous medium at different concentrations and temperatures (from 298.15 K to 313.15 K), and the sound velocity and surface tension study are done only at 298.15 K. The experimental data have been analyzed to interpret different derived parameters as well some thermo-acoustical parameters. The surface tensionvalues have also been determined by means of Stalagmometer and the obtained values are compared with the values computed from sound velocity and density values. Insights obtained from the present study about different molecular interactions of ibuprofen can assist public health and waste management authorities to improve pharmaceutical resource handling and management in rural and urban areas. Determination of solubility.As IBP is very less soluble in water, for its solubility measurement an excess quantity of IBP in 100 mL of conductivity water was taken and heated for 30 minutes maintained at 50°C.

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Insight into Innovative Applications of Parenteral Formulations

Fernandes

2019

Innovative Dosage Forms

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Solubility and Solubilization Approaches in Pharmaceutical Product Development

Cited by 5 publications

References 176 publications

Application of Sol–Gels for Treatment of Gynaecological Conditions—Physiological Perspectives and Emerging Concepts in Intravaginal Drug Delivery

Application of Sol–Gels for Treatment of Gynaecological Conditions—Physiological Perspectives and Emerging Concepts in Intravaginal Drug Delivery

An environmental remediation: study of molecular interactions of the poorly soluble pharmaceutical drug ibuprofen in aqueous media

Insight into Innovative Applications of Parenteral Formulations

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