An environmental remediation: study of molecular interactions of the poorly soluble pharmaceutical drug ibuprofen in aqueous media

Abstract

Medication disposal today is an alarming issue and gaining much more awareness from the consumers as well as healthcare professionals. Various molecular interactions surviving in aqueous drug systems may be considered responsible for these health hazards. This paper reports an experimental study of the various physico-chemical properties of poorly water soluble drug, ibuprofen in aqueous system. Conductance of ibuprofen been measured in aqueous medium at different concentrations and temperatures (from 298.15 K to 313.15 K), and the sound velocity and surface tension study are done only at 298.15 K. The experimental data have been analyzed to interpret different derived parameters as well some thermo-acoustical parameters. The surface tensionvalues have also been determined by means of Stalagmometer and the obtained values are compared with the values computed from sound velocity and density values. Insights obtained from the present study about different molecular interactions of ibuprofen can assist public health and waste management authorities to improve pharmaceutical resource handling and management in rural and urban areas. Determination of solubility.As IBP is very less soluble in water, for its solubility measurement an excess quantity of IBP in 100 mL of conductivity water was taken and heated for 30 minutes maintained at 50°C.