Solubility and dissolution improvement of ketoprofen by emulsification ionic gelation

Rachmaniar, Revika; Tristiyanti, Deby; Hamdani, Syarif; ‘Afifah, Zulfa Nur’aini

doi:10.1063/1.5021217

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Moreover, this BCS Class II drug is known for its low bioavailability due to its high permeability and low solubility. 15 In this study, we used 3D-printing technology to develop patient-tailored enteric capsules filled with a self-nanoemulsifying drug-loaded formulation. For the capsule fabrication, we used HPMCP owing to its pH sensitivity 16 or poly(vinyl alcohol) (PVA), which in a previous study, showed delayed release properties depending on the capsule thickness.…”

Section: Introductionmentioning

confidence: 99%

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Modified Release 3D-Printed Capsules Containing a Ketoprofen Self-Nanoemulsifying System for Personalized Medical Application

Shaqour,

Natsheh,

Kittana

et al. 2024

ACS Biomater. Sci. Eng.

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This study explores the realm of personalized medicine by investigating the utilization of 3D-printed dosage forms, specifically focusing on patient-specific enteric capsules designed for the modified release of ketoprofen, serving as a model drug. The research investigates two distinct scenarios: the modification of drug release from 3D-printed capsules crafted from hydroxypropyl methylcellulose phthalate:polyethylene glycol (HPMCP:PEG) and poly(vinyl alcohol) (PVA), tailored for pH sensitivity and delayed release modes, respectively. Additionally, a novel ketoprofen-loaded self-nanoemulsifying drug delivery system (SNEDDS) based on pomegranate seed oil (PSO) was developed, characterized, and employed as a fill material for the capsules. Through the preparation and characterization of the HPMCP:PEG based filament via the hot-melt extrusion method, the study thoroughly investigated its thermal and mechanical properties. Notably, the in vitro drug release analysis unveiled the intricate interplay between ketoprofen release, polymer type, and capsule thickness. Furthermore, the incorporation of ketoprofen into the SNEDDS exhibited an enhancement in its in vitro cylooxygenase-2 (COX-2) inhibitory activity. These findings collectively underscore the potential of 3D printing in shaping tailored drug delivery systems, thereby contributing significantly to the advancement of personalized medicine.

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Section: Introductionmentioning

confidence: 99%

“…Recent reports implicate NSAID use in mucosal injury in the small and large intestine. Moreover, this BCS Class II drug is known for its low bioavailability due to its high permeability and low solubility …”

Section: Introductionmentioning

confidence: 99%