Solitary metastasis of renal cell carcinoma to the parotid gland 10 years after radical nephrectomy

Abstract

Renal cell carcinoma metastasis to the parotid gland after tumor nephrectomy is extremely rare. We report a case of solitary parotid metastasis from clear cell renal cell carcinoma in a 59-year-old woman, who presented 10 years after primary treatment. To our knowledge this is the first case in the published literature presenting with solitary parotid metastasis after such a long time. Superficial parotidectomy with preservation of the facial nerve was performed. One year after, the patient developed contralateral multiple kidney tumors and underwent left radical nephrectomy. She is currently on a dialysis program and no additional metastasis has been observed for 18 months.

Metastatic Renal Cell Carcinoma to the Parotid Gland in the Setting of Chronic Lymphocytic Leukemia

“…Although the most common sites for RCC metastasis are the lung, lymph nodes, bone, liver, adrenal, and brain, this neoplasm may involve any organ including the parotid as an unusual metastatic site [1, 2]. It is well described in the literature to metastasize to regions in the head and neck.…”

Parotid Metastasis of Renal Cell Carcinoma: A Case Report and Review of the Literature

“…The first case of RCC metastatic to the parotid gland was published by Patey et al in 1965 [7]. Since then there have only been 45 reported cases reported in the English literature [5,39]. Although this entity is uncommon in presentation, this review highlights issues that may assist the head and neck surgeon with a pathologic diagnosis not often encountered cephalad to the clavicles.…”

“…The English literature reports 45 cases of RCC metastatic to the parotid gland since 1965 [5,39]. Only 31 complete case presentations have been documented ( Table 1).…”

“…Eight of the articles published since 1989 described immunohistochemical stains used to identify the primary tumor (Table 1) [9,[11][12][13][14]20,28,39]. RCC consistently stained positive for proximal nephron renal antigen (PNRA), vimentin, CD10, and cytokeratin (CAM5.2).…”

“…Only 31 complete case presentations have been documented ( Table 1). [5, [7][8][9][10][11][13][14][15][16][17]19,20,[22][23][24][25][26][27][28][29][30][32][33][34][35]39]. There was a 2:1 male predominance.…”