Parotid Metastasis of Renal Cell Carcinoma: A Case Report and Review of the Literature

Wein, Richard O.; Lawlor, Claire M.

doi:10.7243/2049-7962-1-15

Cited by 6 publications

(16 citation statements)

References 30 publications

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“…Epidemiological data show that cases in male patients predominated (2 : 1) in the published cases [14,46], reflecting the epidemiology of this malignancy [11,14,46], whereas in our series the reverse was observed (M : F = 1 : 2). The peak incidence occurs in the 7 th to 8 th decade.…”

Section: Discussionsupporting

confidence: 43%

“…It is estimated that 30% of organ-confined RCCs will develop metastatic disease after local treatment [11]. Non-central nervous system (non-CNS) head and neck metastases from RCC are uncommon, comprising approximately 15% of tumors [12], but are not infrequently identified in the skin, nasal cavity, lips, hard palate, tongue, sinuses, and tonsils [6,10,13,14]. The thyroid gland is the most common site of head and neck metastasis for RCC [15].…”

Section: Introductionmentioning

confidence: 99%

“…Since the initial report of Patey et al [16], 46 cases with a predominance of parotid gland metastases have been published [14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46]. Among them, two reports contained detailed and full reviews of the literature [14,46]. Renal cell carcinoma metastases to the submandibular gland were reported in seven cases [47,48,49,50,51,52].…”

Section: Introductionmentioning

confidence: 99%

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Renal clear cell carcinoma metastasis to salivary glands – a series of 9 cases: clinico-pathological study

Majewska¹,

Skálová²,

Radecka³

et al. 2016

pjp

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Metastatic tumors involving salivary glands arising from the non-head and neck area are very rare. Renal cell carcinoma (RCC) is known for its high propensity for metastasis to unusual localizations. RCC metastasis to the maxillofacial area is an uncommon event (16%), but metastasis to salivary glands is extremely rare. We report a series of 9 such cases retrieved from two institutions. The group included 6 females and 3 males. The age at diagnosis ranged from 60 to 97 years (mean 72.6 years). The tumors involved the parotid gland in 7 cases, and the submandibular and small salivary gland of the oral cavity in 1 case each. The size of tumors ranged from 0.4 to 5 cm. Total parotidectomy with selective neck dissection was performed in 4 cases, while superficial parotidectomy was performed in 1 case and simple resection in 3 cases. Histologically, all the tumors were clear cell renal cell carcinomas, and therefore the differential diagnosis mainly included clear cell variants of salivary gland carcinomas. The parotid gland was the initial manifestation of renal malignancy in 4 of the cases, while in the remaining 5 cases a history of RCC had been known. The salivary gland involvement developed from 11 months to 13 years after the time of diagnosis of the primary tumor. In 2 cases it was the first site of dissemination. Pathologists need to maintain a high index of suspicion for the possibility of metastasis when confronted with oncocytic or clear cell neoplasms developing in salivary glands. RCC, although rare, should be included in this differential diagnosis.

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Section: Discussionsupporting

confidence: 43%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Renal clear cell carcinoma metastasis to salivary glands – a series of 9 cases: clinico-pathological study

Majewska¹,

Skálová²,

Radecka³

et al. 2016

pjp

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“…The first cases of parotid involvement due to RCC metastases were reported by Patey et al in 1965 7 . Since then, there have been limited reported cases of this phenomenon 6,[8][9][10][11][12][13][14][15][16] . In their review of the literature, Lawlor et al reported 45 cases of RCC metastasizing to the parotid, of which only 31 were complete case presentations 6 .…”

Section: Discussionmentioning

confidence: 99%

“…The RCC is recognized for its unique metastasis pattern owing to its ability to spread by mainly vascular, yet also lymphatic channels 5,6 . Well established sites for metastasis are bone, adrenals, lung and the contralateral kidney; however, metastasis to the head and neck is extremely rare 6 . We report a rare case of the CCRCC metastasizing to the parotid gland more than five years following nephrectomy.…”

Section: Introductionmentioning

confidence: 99%

Rare case of Clear Cell Renal Cell Carcinoma metastasizing to contralateral kidney and ipsilateral parotid more than five years following nephrectomy

Sydney¹,

Ioakim²,

Kara³

et al. 2019

Balkan J Dent Med

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Summary Backgroung/Aim: Salivary gland malignancies are rare, with only a fraction due to metastases. We report a rare case of the Clear Cell Renal Cell Carcinoma (CCRCC), a subtype of the Renal Cell Carcinoma (RCC), metastasizing to the parotid gland more than five years following nephrectomy. Case report: A 75-year-old female presented with a unilateral left parotid mass that was growing over the period of 18 months. After clinical and laboratory examinations, the patient underwent left partial superficial parotidectomy with preservation of the facial nerve. The significance of the patient’s history of the CCRCC was pivotal to the histopathological diagnosis of a metastatic CCRCC to the parotid. Conclusions: The unpredictable nature of the RCC results in the need for a long period of follow-up, as well as having a high degree of suspicion of metastasis in a patient presenting with a medical history of the RCC and a parotid mass.

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Renal Cell Carcinoma Presenting as Bulky Parotid Mass—a Case Report and Review of Literature

Gopan

Kamala

Radhakrishnan

2021

Indian J Surg Oncol

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Parotid Metastasis of Renal Cell Carcinoma: A Case Report and Review of the Literature

Abstract: Background: To review the presentation and management of renal cell carcinoma metastatic to the parotid gland.

Cited by 6 publications

References 30 publications

Renal clear cell carcinoma metastasis to salivary glands – a series of 9 cases: clinico-pathological study

Renal clear cell carcinoma metastasis to salivary glands – a series of 9 cases: clinico-pathological study

Rare case of Clear Cell Renal Cell Carcinoma metastasizing to contralateral kidney and ipsilateral parotid more than five years following nephrectomy

Renal Cell Carcinoma Presenting as Bulky Parotid Mass—a Case Report and Review of Literature

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