Metastatic renal cell carcinoma, clear cell type, of the parotid gland

Udager, Aaron M.; Rungta, Shilpa

doi:10.1002/dc.23103

Cited by 22 publications

(15 citation statements)

References 34 publications

(54 reference statements)

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“…Classically, RCC presents positive immunohistochemical staining for vimentin and cytokeratin, and negative staining for CK-7 and CK-20. All of these markers were present in this case report 5 .…”

Section: /6supporting

confidence: 56%

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Parotid matastasis of clear-cell renal cell carcinoma (ccRCC): a case report

Martire¹,

Villena²,

Sousa³

et al. 2021

Arch. Head Neck Surg.

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Introduction: Malignant neoplasm of the mouth is a very common disease, being the sixth most common cancer location worldwide. Objective: This study was conducted with the aim of evaluating the applicability and the relationship between cell damage intensity and Oral cavity squamous cell carcinoma (OCSCC) clinical stages. Methods: A total of 44 individuals, 24 oral cancer patients and 20 healthy volunteers participated in this study. The exfoliated cells from the oral cavity were collected using a wooden spatula. All samples were analyzed by comet assay, micronucleus assay and cell death assay. Results: Our results indicate that the diagnosis of OCSCC increases the frequency of genotoxic damage (comet assay -3.21x; micronucleus assay -3.93x). However, it was not possible to establish a correlation between frequency of DNA damage and disease staging. The cell death assay was not effective for the proposed biomonitoring. Given these findings, we consider the comet and micronucleus assays to be adequate for biomonitoring DNA damage. Conclusion: With the current design, we could not demonstrate the applicability of these assays to correlate the intensity of DNA/cell damage and the clinical stages of OCSCC. Nevertheless, further studies need to be performed to enhance sample size and increase the statistical power of our findings

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Section: /6supporting

confidence: 56%

“…Metastasis occurs in only 1-4% of all salivary gland tumors, and the parotid is the most affected 4 . Approximately 0.1% of all salivary gland metastatic neoplasms originate from renal malignancies 5 . Parotid neoplasm is diagnosed from a thorough clinical history and physical examination of the patient.…”

mentioning

confidence: 99%

Parotid matastasis of clear-cell renal cell carcinoma (ccRCC): a case report

Martire¹,

Villena²,

Sousa³

et al. 2021

Arch. Head Neck Surg.

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“…Our research strategy revealed a total of 83 relevant papers published from 1965-2022 (a few references). [ 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 ] A total of 100 patients included 55 males and 35 females with a male to female ratio of 1.6:1. The maximum number of cases were from the USA ( n = 17) followed by Poland ( n = 11), Turkey = UK ( n = 10), and Japan = Italy ( n = 8).…”

Section: Resultsmentioning

confidence: 99%

Renal cell carcinoma metastasizing to salivary glands: Systematic review

Gupta,

Alruwaili,

Escobedo

et al. 2024

National Journal of Maxillofacial Surgery

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Distant metastasis to salivary glands is a very rare event. Renal cell carcinoma (RCC) has been known for its high propensity of metastasis to unusual locations and salivary glands are one among those sites. Approximately 0.1% of all salivary gland metastatic neoplasms originate from renal malignancies Literature has reported several studies analysing the metastatic tumors to the oral region. However, very little research work has been published to date to analyse solely the RCC metastasizing to the salivary glands. Thus, this review was conducted to examine the published cases of RCC metastasizing to salivary glands in the literature to date and to learn about their characteristics. An electronic search of the published literature was performed without publication year limitation in PubMed/ Medline, Scopus, Google Scholar, Web of Science, Science Direct, Embase, and Research Gate databases, using mesh keywords like (‘Renal cancer’, OR ‘Renal carcinoma’ OR ‘Renal cell cancer’ OR ‘Renal cell carcinoma’), AND (‘Metastasis’ OR ‘Metastases’), And (‘Salivary glands’ OR ‘Parotid gland’ OR ‘Submandibular gland’ OR ‘Sublingual gland’). We also searched all related journals manually. The reference list of all articles was also checked. Our research revealed a total of 83 relevant papers (1965-2022) with 100 patients. Parotid was the most predominant gland affected. 8% of patients died with a mean survival time of 1.3 yr. From this research, it can be concluded that RCC metastasizing to salivary glands is a rare occurrence. Careful evaluation of these cases is needed in order to raise awareness of these lesions and gain a better understanding of their characteristics for clinical as well as global implications.

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“…The first cases of parotid involvement due to RCC metastases were reported by Patey et al in 1965 7 . Since then, there have been limited reported cases of this phenomenon 6,[8][9][10][11][12][13][14][15][16] . In their review of the literature, Lawlor et al reported 45 cases of RCC metastasizing to the parotid, of which only 31 were complete case presentations 6 .…”

Section: Discussionmentioning

confidence: 99%

Rare case of Clear Cell Renal Cell Carcinoma metastasizing to contralateral kidney and ipsilateral parotid more than five years following nephrectomy

Sydney¹,

Ioakim²,

Kara³

et al. 2019

Balkan J Dent Med

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Summary Backgroung/Aim: Salivary gland malignancies are rare, with only a fraction due to metastases. We report a rare case of the Clear Cell Renal Cell Carcinoma (CCRCC), a subtype of the Renal Cell Carcinoma (RCC), metastasizing to the parotid gland more than five years following nephrectomy. Case report: A 75-year-old female presented with a unilateral left parotid mass that was growing over the period of 18 months. After clinical and laboratory examinations, the patient underwent left partial superficial parotidectomy with preservation of the facial nerve. The significance of the patient’s history of the CCRCC was pivotal to the histopathological diagnosis of a metastatic CCRCC to the parotid. Conclusions: The unpredictable nature of the RCC results in the need for a long period of follow-up, as well as having a high degree of suspicion of metastasis in a patient presenting with a medical history of the RCC and a parotid mass.

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Metastatic renal cell carcinoma, clear cell type, of the parotid gland

Cited by 22 publications

References 34 publications

Parotid matastasis of clear-cell renal cell carcinoma (ccRCC): a case report

Parotid matastasis of clear-cell renal cell carcinoma (ccRCC): a case report

Renal cell carcinoma metastasizing to salivary glands: Systematic review

Rare case of Clear Cell Renal Cell Carcinoma metastasizing to contralateral kidney and ipsilateral parotid more than five years following nephrectomy

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