Solitary Langerhans' cell granulomatosis of the stomach associated with gastric carcinoma

Arrinda, J. M.; Vilanova, J. R.; Zabalza, Ignacio; Ortega, F.; Bilbao, Francisco José Larrea; Rivera‐Pomar, J. M.

doi:10.1007/bf00707995

Cited by 3 publications

(2 citation statements)

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“…In another case, the same T cell receptor arrangement was identified in both the LCH and T cell acute lymphoblastic leukemia (T‐ALL) 14. Only a few cases of concurrent LCH and solid tumors other than malignant lymphoma have been reported: 9 lung cancers and 1 stomach cancer in adults 8–11 and 3 retinoblastomas and 1 neuroblastoma in children 7, 12, 13. The current standard for the initial treatment of patients with LCH is to use the least toxic therapy.…”

Section: Discussionmentioning

confidence: 96%

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Concurrent Langerhans cell histiocytosis and nephroblastoma

Narui

Yagasaki

Takahashi

et al. 2009

Pediatric Blood & Cancer

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Both Langerhans cell histiocytosis (LCH) and nephroblastoma are rare in children. We report herein the first case of a patient with both diseases concurrently. A 2-year-old female presented with bone pain and swelling of the right humerus. As a result of the local incision biopsy, she was diagnosed as LCH. A nephroblastoma of the left kidney was discovered during her staging work-up. After complete resection of the nephroblastoma, she received standard chemoradiotherapy for nephroblastoma. She is alive without relapse 14 months after initial presentation.

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Section: Discussionmentioning

confidence: 96%

“…There have been reports of LCH associated with various malignancies 6–13. Among them, a large group of patients had hematological diseases including leukemia and malignant lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Concurrent Langerhans cell histiocytosis and nephroblastoma

Narui

Yagasaki

Takahashi

et al. 2009

Pediatric Blood & Cancer

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Association of langerhans cell histiocytosis with malignant neoplasms

Egeler

Neglia

Puccetti

et al. 1993

Cancer

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Background. The association of Langerhans cell histiocytosis (LCH) with a malignant neoplasm is rare and generally has been the subject of isolated case reports. Methods. A recent case of LCH seen at the University of Minnesota in combination with acute lymphoblastic leukemia led the authors to review their own charts from 1960 onward, in addition to the literature for other reported associations of LCH and malignant neoplasms. Results. In addition to the presented case and 3 cases from the files of the authors, the literature contained 87 reported cases. Of the 91 patients, 39 had LCH with malignant lymphoma (ML); 25 of these cases were Hodgkin disease. In 11 of these 39 patients, the LCH was diagnosed from 12 months to 33 years after the ML was diagnosed. In 62% of the patients with LCH–ML (24 patients), the diagnosis was made concurrently and the Langerhans cells were found in the same lymph nodes. In the remaining four patients, the diagnosis of LCH preceded that of ML by 6–24 months. In 22 patients, including 2 patients in the files of the authors, LCH was reported in association with leukemia; 16 (73%) of these cases were associated with acute nonlymphoblastic leukemia. In two cases the leukemia preceded the LCH. In 6 patients both diagnoses were made concurrently, and in 14 patients (64%) the diagnosis of LCH preceded the diagnosis of leukemia by 8 months to 17 years. In the remaining 30 patients, LCH was associated with a variety of solid tumors, including a lung carcinoma in 12 patients. In all of these 12 cases the LCH was confined to the lung, and in 75% (9 of 12) of patients the diagnoses were made concurrently. In the 16 patients in whom the LCH preceded the solid tumor, the malignant diseases in 69% (11 of 16) developed within the radiation field used for the treatment of the LCH. Conclusions. The intimate and simultaneous association of LCH with ML and lung carcinomas suggests strongly that the process that leads to the association is a reactive one. However, in the patients with leukemia and the other solid tumors, the latency of the malignant neoplasm after the diagnosis of LCH is suggestive of a therapy‐related process.

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