Gastric Adenocarcinoma Associated with Granulomatous Gastritis. Case Report and Review of the Literature

Bigotti, Giulio; Coli, Antonella; Magistrelli, Paolo; Ninno, Maria De; Antonacci, Vincenzo; Crucitti, Antonio; Federico, Francesco; Antinori, Armando; Massi, Guido

doi:10.1177/030089160208800216

Cited by 12 publications

(8 citation statements)

References 10 publications

(1 reference statement)

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“…Some authors have found a better prognosis in some tumors [20][21], while others have not [22]. As we did not find a report concerning their presence in PDAC, some cases with favorable outcomes of granuloma associated with signet ring cell gastric carcinoma, which have also prominent desmoplasia, had been reported [23][24]. Macrophage attraction to tumoral sites is induced by the secretion of chemokines in the milieu, such as chemokine (C-C motif) ligand 5 (CCL5), which also has a role in granuloma formation [25].…”

Section: The Siege Strategycontrasting

confidence: 62%

Besieging the Tumoral Sites: Could It Be an Alternative Therapeutic Strategy in Ductal Pancreatic Adenocarcinoma?

Delma¹

2020

Cureus

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Pancreatic ductal adenocarcinoma is characterized by its high morbidity, and curative drugs are still lacking. In addition to immunotherapy, other molecular targeted therapeutics, such as stroma depleting agents, have been evaluated, given the abundant desmoplastic stroma that is considered a protective shield for tumor cells. However, the unexpected poor outcome has raised the debate on whether desmoplasia promotes or restrains tumor cell spread. After reviewing these key points in this paper, an approach taking advantage of desmoplasia and immune cells to besiege the tumoral sites will be proposed. Based on the available literature, the feasibility and potential limitations of this strategy will be discussed.

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Section: The Siege Strategycontrasting

confidence: 62%

Besieging the Tumoral Sites: Could It Be an Alternative Therapeutic Strategy in Ductal Pancreatic Adenocarcinoma?

Delma¹

2020

Cureus

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“…7 8 It has also been observed in breast, gastric, colonic and laryngeal cancer along with head and neck cancer. [9][10][11] However, literature reporting such non-specific granulomatous inflammation, namely sarcoid reaction in lung cancer, is limited. 4 5 12-14 Most of the reports describe sarcoid-like lymphadenopathy in patients with lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Significance of coexistent granulomatous inflammation and lung cancer

et al. 2016

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AimsCoexistence of lung cancer and granulomatous inflammation in the same patient confuses clinicians. We aimed to document the prevalence, clinicopathological features, treatment outcomes and prognosis in patients with coexisting granulomatous inflammation undergoing curative lung resection for lung cancer, in a tuberculosis (TB)-endemic country.MethodsAn observational cohort study of patients with lung cancer undergoing curative resection between 2012 and 2015 in a tertiary centre in Singapore.ResultsOne hundred and twenty-seven patients underwent lung resection for cancer, out of which 19 (14.9%) had coexistent granulomatous inflammation in the resected specimen. Median age was 68 years and 58.2% were males. Overall median (range) survival was 451 (22–2452) days. Eighteen (14%) patients died at median duration of 271 days after surgery. The postsurgery median survival for those alive was 494 (29–2452) days in the whole group. Subgroup analysis did not reveal any differences in age, gender, location of cancer, radiological features, type of cancer, chemotherapy, history of TB or survival in patients with or without coexistent granulomatous inflammation.ConclusionsIncidental detection of granulomatous inflammation in patients undergoing lung resection for cancer, even in a TB-endemic country, may not require any intervention. Such findings may be due to either mycobacterial infection in the past or ‘sarcoid reaction’ to cancer. Although all patients should have their resected specimen sent for acid-fast bacilli culture and followed up until the culture results are reported, the initiation of the management of such patients as per existing lung cancer management guidelines does not affect their outcome adversely.

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“…Gastric granulomas may also occur in association with adenocarcinomas and mucosa‐associated lymphoid tissue (MALT) lymphomas 96 . In the former, they appear to be an inflammatory response to invasive tumour or extravasated mucin, similar to what has been described at other sites.…”

Section: Miscellaneous Forms Of Gastritis With a Distinctive Histologymentioning

confidence: 83%

Pathology of non‐infective gastritis

Srivastava

Lauwers

2006

Histopathology

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The discovery of Helicobacter pylori and its intimate role in the development of the most common form of chronic gastritis has elicited a much-needed interest in non-neoplastic gastric pathology. This has been paralleled by an increase in upper endoscopic examinations, which allow recognition of novel patterns and distribution of mucosal injury. Numerous attempts at classification have been made, most based on the acuteness or chronicity of gastric mucosal injury. In this review, we will not offer a new classification but present a detailed description of the major clinicopathological entities, based either on the salient morphological features or the underlying aetiologies, i.e. iatrogenic, autoimmune, vascular or idiopathic.

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Gastric Adenocarcinoma Associated with Granulomatous Gastritis. Case Report and Review of the Literature

Abstract: To the best of our knowledge this is the fourth example of gastric adenocarcinoma and granulomatous gastritis. These cases suggest an association between granulomatous gastritis and early gastric cancer.

Cited by 12 publications

References 10 publications

Besieging the Tumoral Sites: Could It Be an Alternative Therapeutic Strategy in Ductal Pancreatic Adenocarcinoma?

Besieging the Tumoral Sites: Could It Be an Alternative Therapeutic Strategy in Ductal Pancreatic Adenocarcinoma?

Significance of coexistent granulomatous inflammation and lung cancer

Pathology of non‐infective gastritis

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