Solid lipid nanoparticles: Preparation techniques, their characterization, and an update on recent studies

doi:10.7324/japs.2020.10617

Cited by 30 publications

(10 citation statements)

References 35 publications

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“…The ultrasonication method and high-speed homogenization can be used in the fabrication of SLNs effectively [ 45 , 81 , 82 ]. The initial step is usually conducted by mixing the components of the active compounds that are put into the melted lipid, and then the liquid phase (which has been heated at the same temperature) is added to the previous mixture and emulsified with ultrasonication or by using a high-speed stirrer.…”

Section: Fabrication Methods For Slnsmentioning

confidence: 99%

“…In addition, this method also has the potential for metal contamination due to the ultrasonication process. The manufacture of SLNs with the ultrasonication method was then developed to form a stable formulation, where the combination of the ultrasonication method and high-speed homogenization at a high temperature can form smaller SLN particles by reducing the surface tension on the nanoparticles [ 81 , 86 ]. The ultrasonication method for SLN fabrication produces nanoparticles that are more optimal when combined with other methods, such as high-shear homogenization.…”

Section: Fabrication Methods For Slnsmentioning

confidence: 99%

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Solid Lipid Nanoparticles: Review of the Current Research on Encapsulation and Delivery Systems for Active and Antioxidant Compounds

2023

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Various active compounds are easily damaged, so they need protection and must be easily absorbed and targeted. This problem can be overcome by encapsulating in the form of solid lipid nanoparticles (SLNs). Initially, SLNs were widely used to encapsulate hydrophobic (non-polar) active compounds because of their matched affinity and interactions. Currently, SLNs are being widely used for the encapsulation of hydrophilic (polar) and semipolar active compounds, but there are challenges, including increasing their entrapment efficiency. This review provides information on current research on SLNs for encapsulation and delivery systems for active and antioxidant compounds, which includes various synthesis methods and applications of SLNs in various fields of utilization. SLNs can be developed starting from the selection of solid lipid matrices, emulsifiers/surfactants, types of active compounds or antioxidants, synthesis methods, and their applications or utilization. The type of lipid used determines crystal formation, control of active compound release, and encapsulation efficiency. Various methods can be used in the SLN fabrication of active compounds and hydrophilic/hydrophobic antioxidants, which have advantages and disadvantages. Fabrication design, which includes the selection of lipid matrices, surfactants, and fabrication methods, determines the characteristics of SLNs. High-shear homogenization combined with ultrasonication is the recommended method and has been widely used because of the ease of preparation and good results. Appropriate fabrication design can produce SLNs with stable active compounds and antioxidants that become suitable encapsulation systems for various applications or uses.

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Section: Fabrication Methods For Slnsmentioning

confidence: 99%

Section: Fabrication Methods For Slnsmentioning

confidence: 99%

Solid Lipid Nanoparticles: Review of the Current Research on Encapsulation and Delivery Systems for Active and Antioxidant Compounds

2023

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“…Different methods for producing SLNs have been developed and proposed over the years [ 16 , 17 ]. Each of them produces particles with specific characteristics and may be applied to different drugs.…”

Section: Slns Production Methodsmentioning

confidence: 99%

“…A brief description of the most common ones is presented below, and an overall comparison of their advantages and disadvantages is presented in Table 2 . A more detailed and schematic representation of the different methods is presented elsewhere [ 10 , 16 , 17 ]. Note that new methods and variations of the presented methods are constantly being proposed.…”

Section: Slns Production Methodsmentioning

confidence: 99%

Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment

et al. 2023

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Despite all the advances seen in recent years, the severe adverse effects and low specificity of conventional chemotherapy are still challenging problems regarding cancer treatment. Nanotechnology has helped to address these questions, making important contributions in the oncological field. The use of nanoparticles has allowed the improvement of the therapeutic index of several conventional drugs and facilitates the tumoral accumulation and intracellular delivery of complex biomolecules, such as genetic material. Among the wide range of nanotechnology-based drug delivery systems (nanoDDS), solid lipid nanoparticles (SLNs) have emerged as promising systems for delivering different types of cargo. Their solid lipid core, at room and body temperature, provides SLNs with higher stability than other formulations. Moreover, SLNs offer other important features, namely the possibility to perform active targeting, sustained and controlled release, and multifunctional therapy. Furthermore, with the possibility to use biocompatible and physiologic materials and easy scale-up and low-cost production methods, SLNs meet the principal requirements of an ideal nanoDDS. The present work aims to summarize the main aspects related to SLNs, including composition, production methods, and administration routes, as well as to show the most recent studies about the use of SLNs for cancer treatment.

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“…Solid lipid nanoparticles (SLNs) are an excellent alternative to enhance the therapeutic effects of coumarin. SLNs have been studied as biodegradable transport systems for many purposes [ 19 , 20 , 21 , 22 ]. In the last two decades, SLNs have been widely used in the pharmaceutical industries as a delivery system for polymer nanoparticles, liposomes, and emulsions.…”

Section: Introductionmentioning

confidence: 99%

Coumarin-Encapsulated Solid Lipid Nanoparticles as an Effective Therapy against Methicillin-Resistant Staphylococcus aureus

et al. 2022

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Bacterial infections caused by antibiotic-resistant pathogens are a significant public health problem. This is because the transmission of infectious diseases is shifting, and new antibiotic-resistant strains of bacteria are emerging. The development of biofilms that are resistant to antibiotics poses another hurdle to drugs and treatment alternatives. Therefore, there is an urgent need to develop innovative strategies to effectively eliminate antibiotic-resistant microorganisms effectively. Natural coumarins have broad spectrum bioactivity and the potential for lower resistance. Coumarin is a secondary metabolite found in certain plants, fungi, and bacteria. It is highly effective against methicillin-resistant Staphylococcus aureus (MRSA). Therefore, coumarin can be used as an alternative to combat MRSA. However, most antibacterial agents lack selective targeting of pathological sites, limiting the efficacy of their antibacterial activity. Efficient MRSA treatments can be achieved through nanoparticle (NPs)-based targeted therapies. To address this challenge, a novel coumarin-loaded solid lipid nanocarrier for MRSA was developed to overcome this challenge. The developed systems exhibited a particle size of 138.5 ± 76.06 nm and a polydispersity index (PDI) of 0.245 ± 0.00. The zeta potential of coumarin-loaded SLNs was reported to be −22.2 ± 8.15 mV with a spherical shape. The encapsulation efficiency of coumarin was reported to be 63.09 ± 3.46% in the final formulation. The developed formulation was biocompatible with a minimum inhibitory concentration (MIC) of 1.08 µg/ml. This study suggests that coumarin-loaded SLNs can effectively treat MRSA infections.

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Solid lipid nanoparticles: Preparation techniques, their characterization, and an update on recent studies

Cited by 30 publications

References 35 publications

Solid Lipid Nanoparticles: Review of the Current Research on Encapsulation and Delivery Systems for Active and Antioxidant Compounds

Solid Lipid Nanoparticles: Review of the Current Research on Encapsulation and Delivery Systems for Active and Antioxidant Compounds

Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment

Coumarin-Encapsulated Solid Lipid Nanoparticles as an Effective Therapy against Methicillin-Resistant Staphylococcus aureus

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