Sol-Gel Synthesis of FHA Nanoparticles and CDHA Agglomerates from a Mixture with a Nonstochiometric Ca/P Ratio

Jahandideh, Rahim; Behnamghader, Aliasghar; Rangie, M.; Youzbashi, A. A.; Joughehdoust, Sedigheh; Tolouei, R.

doi:10.4028/www.scientific.net/kem.396-398.607

Cited by 11 publications

(14 citation statements)

References 13 publications

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“…Synthesis of CaP NPs is an intimate part of drug loading or incorporation processes. Synthesis of CaP NPs can be done by various methods such as wet precipitation [53–56], solid state reaction, sol–gel [57–60], flame spray pyrolysis [61], hydrothermal [62], spray-drying [63], micelle mediated [64], reverse micelle mediated [65–67], and double emulsion mediated synthesis [68]. …”

Section: Calcium Phosphate Nanoparticles (Cap Nps) In Drug Deliverymentioning

confidence: 99%

Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

2012

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Calcium phosphates (CaPs) are the most widely used bone substitutes in bone tissue engineering due to their compositional similarities to bone mineral and excellent biocompatibility. In recent years, CaPs, especially hydroxyapatite and tricalcium phosphate, have attracted significant interest in simultaneous use as bone substitute and drug delivery vehicle, adding a new dimension to their application. CaPs are more biocompatible than many other ceramic and inorganic nanoparticles. Their biocompatibility and variable stoichiometry, thus surface charge density, functionality, and dissolution properties, make them suitable for both drug and growth factor delivery. CaP matrices and scaffolds have been reported to act as delivery vehicles for growth factors and drugs in bone tissue engineering. Local drug delivery in musculoskeletal disorder treatments can address some of the critical issues more effectively and efficiently than the systemic delivery. CaPs are used as coatings on metallic implants, CaP cements, and custom designed scaffolds to treat musculoskeletal disorders. This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.

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Section: Calcium Phosphate Nanoparticles (Cap Nps) In Drug Deliverymentioning

confidence: 99%

Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

2012

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“…Most of these techniques produced rod-like crystals or whiskers, while plate-like shapes were obtained in just a few studies [335,345,347]. Other preparation methods of nanodimensional and/or nanocrystalline apatites of various states, shapes and sizes include sol-gel [30,188,231,232,270,328,[360][361][362][363][364][365][366][367][368][369][370][371][372][373][374][375][376], co-precipitation [271,333,334,[377][378][379][380], mechanochemical approach[65, 250,343,348,[381][382][383][384][385][386][387], mechanical alloying [388,389], ball milling [348,383,…”

Section: Nanodimensional and Nanocrystalline Apatitesmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Dorozhkin¹

2012

AJBE

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Nano-sized particles and crystals play an important role in the formation of calcified tissues of various animals. For example, nano-sized and nanocrystalline calcium orthophosphates in the form of apatites of biological origin represent the basic inorganic building blocks of bones and teeth of mammals. Namely, according the recent developments in biomineralization, tens to hundreds nanodimensional crystals of a biological apatite are self-assembled into these complex structures. This process occurs under a strict control by bioorganic matrixes. Furthermore, both a greater viability and a better proliferation of various types of cells have been detected on smaller crystals of calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the hard tissue-engineering field, starting from bone repair and augmentation to controlled drug delivery systems. This review reports on current state of the art and recent developments on the subject, starting from synthesis and characterization to biomedical and clinical applications. Furthermore, the review also discusses possible directions for future research and development.

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“…To prepare nanodimensional and/or nanocrystalline apatites, methods of wet chemical precipitation [62,71,73,86,119,121,155,156,157,160,166,186,187,237,246,258,259,260,261,262,263,264,265,266,267,268,269,270,271,272,273,274,275,276,277,278,279,280,281,282,283,284,285,286,287,288], sol-gel synthesis [30,176,210,211,242,288,289,290,291,292,293,294,295,296,297,298,299], co-precipitation [243,300…”

Section: Synthesis Of the Nanodimensional And Nanocrystalline Calcmentioning

confidence: 99%

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

Dorozhkin¹

2009

Materials

243

150

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Recent developments in biomineralization have already demonstrated that nanosized particles play an important role in the formation of hard tissues of animals. Namely, the basic inorganic building blocks of bones and teeth of mammals are nanodimensional and nanocrystalline calcium orthophosphates (in the form of apatites) of a biological origin. In mammals, tens to hundreds nanocrystals of a biological apatite were found to be combined into self-assembled structures under the control of various bioorganic matrixes. In addition, the structures of both dental enamel and bones could be mimicked by an oriented aggregation of nanosized calcium orthophosphates, determined by the biomolecules. The application and prospective use of nanodimensional and nanocrystalline calcium orthophosphates for a clinical repair of damaged bones and teeth are also known. For example, a greater viability and a better proliferation of various types of cells were detected on smaller crystals of calcium orthophosphates. Thus, the nanodimensional and nanocrystalline forms of calcium orthophosphates have a great potential to revolutionize the field of hard tissue engineering starting from bone repair and augmentation to the controlled drug delivery devices. This paper reviews current state of knowledge and recent developments of this subject starting from the synthesis and characterization to biomedical and clinical applications. More to the point, this review provides possible directions of future research and development.

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Sol-Gel Synthesis of FHA Nanoparticles and CDHA Agglomerates from a Mixture with a Nonstochiometric Ca/P Ratio

Cited by 11 publications

References 13 publications

Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

Nanodimensional and Nanocrystalline Calcium Orthophosphates

Nanodimensional and Nanocrystalline Apatites and Other Calcium Orthophosphates in Biomedical Engineering, Biology and Medicine

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