Sol-Gel Synthesis and Characterization of Lanthanide-Substituted Nanostructured Calcium Hydroxyapatite

Abstract

In this study, nanostructured Ce- and Sm-substituted Ca10(PO4)6(OH)2 samples have been synthesized using an aqueous sol-gel chemistry route. For the characterization of obtained specimens, the XRD, SEM, UV-visible reflection and IR spectroscopy and luminescence measurements were recorded. It was shown that phase purity of the end products highly depends on the amount of lanthanide element. The reflectance of lanthanide-substituted calcium hydroxyapatite samples is wavelength independent in the wavelength range of 450-800 nm and equal almost 100%. The cerium-substituted samples show a significant decrease of transmission at ~300 nm. The characteristic samarium absorption line (~430 nm) is evident in the UV-vis reflection spectra of samarium-substituted hydroxyapatites.

Samarium doped glass-reinforced hydroxyapatite with enhanced osteoblastic performance and antibacterial properties for bone tissue regeneration

“…Incorporated Ln 3+ in the HA matrix include (La 3+ ), [19][20][21] (Y 3+ ) and (In 3+ ), 19 (Sm 3+ ) and (Gd 3+ ) 22 and, also, in nanostructured HA, namely (Ce 3+ ) 23 and (Ce 3+ & Sm 3+ ). 24 HA and TCP lanthanum phosphate composites have also been reported. 25 An important feature of lanthanides is their apparent antimicrobial properties.…”

Sol–gel synthesis of calcium phosphate-based biomaterials—A review of environmentally benign, simple, and effective synthesis routes

“…Metal-substituted Ca 10 (PO 4 ) 6 (OH) 2 nanocrystallites were also synthesized by an aqueous sol-gel synthesis routes [135,136,144,146,151,154,158,160,163,164,166,168,170,172,[174][175][176]. In most of the cases cationic substitution of calcium did not changed the surface morphology of the end product.…”

Sol-gel synthesis and characterization of samarium and manganese substituted calcium hydroxyapatite, Ca10(PO4)6(OH)2

“…It was also suggested that transition metals and lanthanide elements might play an important role in enamel demineralization reduction [15,16]. Apatites with the chemical formula Sr 7-x Ca x La 3 (PO 4 ) 3 (SiO 4 ) 3 F 2 , where x = 0, 1 and 2, were prepared by mechanochemical synthesis using a planetary mill [17].…”