Samarium doped glass-reinforced hydroxyapatite with enhanced osteoblastic performance and antibacterial properties for bone tissue regeneration

Abstract

Cell adhesion of MG63 osteoblastic cells seeded over GR-HA_control and Sm doped composites, at day 1 of culture. Low (A) and high (B) CLSM images of cells stained for F-actin cytoskeleton (green) and nuclei (red); (C) SEM images.

In‐vitro biocompatibility, bioactivity and photoluminescence properties of Eu3+/Sr2+ dual‐doped nano‐hydroxyapatite for biomedical applications

“…In addition, the charge imbalance on Ln 3+ ions is not a restraint to replace Ca 2+ . Consequently, rare earths incorporated into HA biomaterials for bone tissue regeneration has also been assessed, and reported to enhance its bioactivity and induce osteoblastic behavior in vitro …”

“…20 Consequently, rare earths incorporated into HA biomaterials for bone tissue regeneration has also been assessed, and reported to enhance its bioactivity and induce osteoblastic behavior in vitro. 22,23 Several reports have come out with various applications for rare earths doped HA, for instance, Nd 31 , Eu 31 , and Gd 31 are observed to have inappreciable toxicity, Nd 31 ions increase the bone density, help in ossification, and influence the bone remodeling cycle thereby applicable in the treatment of osteoporosis. 24 The higher content of Ce 31 ions inclusion in HA may lead to a better antibacterial effect against the hip and knee joint infections.…”

Investigation of Anticorrosion, Antibacterial and In Vitro Biological Performance of Terbium / Gadolinium Dual Substituted Hydroxyapatite Coating on Surgical Grade Stainless Steel for Biomedical Applications

“…Therefore the substitution of Ca 2+ with other metal ions (Zn, Tb, Sm, Ce, Eu. etc...) plays an essential role in the improvement of biological performance of hydroxyapatite [17][18][19][20][21][22][23][24] . In particular, Terbium ions plays a major role in improving the biocompatibility and biodegradability of hydroxyapatite bioceramics which enhances the in vitro and in vivo osteoblast cell proliferation and growth.…”

Exploration on Anticorrosive, Antibacterial and Osteocompatibility Properties of Samarium/Europium Substituted Hydroxyapatite Coating on Surgical Grade Stainless Steel for Biomedical Applications

“…Several important features of lanthanide ions professed in biological properties. Hence, Sm-HAP has been used in the subject of great interest due to the significant role of this ion in the improved osteoblastic performance, good antibacterial properties and biologically bone targeted radio therapeutic agent play in preventing caries [16,17]. The samarium ions have been used for bone metastatic prostate cancer and depen-dent on prior treatments.…”