“…Software sensors have been described for diverse applications, such as chemical reactors (Régnier et al, 1996), analytical devices (Matsumura et al, 1998), environmental processes (Carstensen et al, 1996), and bioprocesses (Kiviharju et al, 2008). In addition, software sensors support the ambition of process analytical technology (PAT) to establish on-line monitoring methods for high quality manufacture of pharmaceutical products (FDA, 2004;Gnoth et al, 2007).…”