Sodium Alginate–locust Bean Gum Ipn Hydrogel Beads for the Controlled Delivery of Nimesulide-Anti-Inflammatory Drug

Abstract

Objective: The objective of this study was to formulate and evaluate the drug release studies using locust bean gum (LBG) and sodium alginate (NaAlg) and cross-linked with glutaraldehyde for the controlled release (CR) of Nimesulide, an anti-inflammatory drug.Methods: Locust bean gum (LBG) and sodium alginate (NaAlg) blend hydrogel beads were prepared by an extrusion method using glutaraldehyde as a crosslinker. Nimesulide an anti-inflammatory drug was encapsulation within LBG/NaAlg blend hydrogel beads. Morphology, size, encapsulation efficiency and drug release from these hydrogel beads were evaluated by different characterization techniques such as fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), x-ray diffraction (X-RD) studies.Results: Drug-loaded hydrogel beads were analyzed by FTIR, which indicates the interaction between drug and polymers. DSC thermograms on drug-loaded microbeads confirmed the polymorphism of Nimesulide and indicated a molecular level dispersion of the drug in the hydrogel beads. SEM confirmed the spherical nature and rough surface of the hydrogel beads produced. X-RD study was performed to understand the crystalline nature of drug after encapsulated into the hydrogel beads and confirmed the complete dispersion of the drug in the polymer matrix. In vitro release studies conducted in pH-7.4 which indicated a dependence of release rate on the amount of drug loading and the amount of LBG/NaAlg, but slow release rates were extended up to 48 h. The cumulative release data were fitted to an empirical equation to compute diffusion exponent (n) which indicated the non-fickian trend for drug release. Conclusion:These results clearly demonstrated that the ability of these newly developed hydrogel beads containing Nimesulide for its sustained release could possibly be advantageous to patient compliance with reduced dosing interval.

Sodium Alginate/Gelatin Microbeads-Intercalated With Kaolin Nanoclay for Emerging Drug Delivery in Wilson’s Disease

“…8. This suggests that drug release rate increases with increasing content of sodium alginate, this is due to hydrophilic nature of sodium alginate [46], whereas the gelatin concentration increases the drug release rate decreases, this is due to the rigid nature of SA/GE blend component and the possible hydrogen-bonding interactions between −COO− of sodium alginate and N-H group of gelatin.…”

Evaluation of the Antibacterial Activity of Calcium Alginate Beads Modified With Ethanolic Extract of Adhatoda Vasica Leaf Extract on Staphylococcus Aureus and Escherichia Coli

“…It has the ability to gel in mild and aqueous conditions in the presence of divalent ions such as Ca 2+ and Zn 2+ and trivalent ions such as Al 3+ and Fe 3+ which leads to the formation of egg box junctions [7]. The biocompatible and non-toxic nature of ALG finds wide applications in the delivery of bioactive agents such as small chemical drugs and proteins, and cell transplantation [8][9][10][11]. ALG is well-known material in the wound management field due to its ability to maintain a moist environment and rich water content [12].…”

The ALGINATE MICROSPHERES CONTAINING CURCUMIN: PREPARATION, CHARACTERIZATION, AND IN VITRO HUMAN HAEMOGLOBIN GLYCOSYLATION ASSAY

“…The increased concentration of polymer may show increased swelling and decreases drug diffusion from the polymer matrix. Literature reported similar discussion [18]. Extend of crosslinking also affect drug release from formulation.…”

“…As the concentration of crosslinker increases, retarded drug release was observed. This may be due to limitations in easy transport of drug molecule from polymer matrix [18,19]. Maximum release from microspheres was observed with phosphate buffer (pH7) as dissolution media.…”