Sodium alginate and gum acacia hydrogels of ZnO nanoparticles show wound healing effect on fibroblast cells

Raguvaran, R.; Manuja, Balvinder K.; Chopra, Meenu; Thakur, Rajesh; Anand, Taruna; Kalia, Anu; Manuja, Anju

doi:10.1016/j.ijbiomac.2016.12.009

Cited by 200 publications

(64 citation statements)

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“…Ionexchange reactions between calcium ions in the dressing and sodium ions in the wound exudate results in the formation of a hydrogel layer on the wound surface, providing a moist environment that promotes wound healing. 17,18 Microuidic techniques have been widely used in recent years for biological detection, drug screening, substance isolation, gene sequencing, and in vitro diagnosis, among others, due to advantages that include low loading volumes, rapid detection, cost effectiveness, and high portability. [19][20][21][22] Many research groups (such as S. H. Lee, J. Qin, Q. Liang, et al) have proposed and used microuidic spinning to fabricate a series of bers with varying morphologies, which broadens the applications of microuidic chips.…”

Section: Introductionmentioning

confidence: 99%

High-water-absorbing calcium alginate fibrous scaffold fabricated by microfluidic spinning for use in chronic wound dressings

et al. 2018

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Section: Introductionmentioning

confidence: 99%

High-water-absorbing calcium alginate fibrous scaffold fabricated by microfluidic spinning for use in chronic wound dressings

et al. 2018

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“…More recently, metal nanomaterials had attracted the scientists' attention in the field of anti-infection because of their ability to overcome existing drug resistance at suitable doses, which can increase cellular uptake and reduce efflux of drugs from the microbial cell [1]. Zinc oxide nanoparticles (ZnONPs), which possess both antibacterial and anti-inflammatory properties and accelerate the healing of both acute and chronic wounds, are an ideal material for using in inhibiting growth of bacteria [2][3][4][5][6]. In addition, zinc is necessary for the human body as a trace element [7].…”

Section: Introductionmentioning

confidence: 99%

Zinc oxide/silver bimetallic nanoencapsulated in PVP/PCL nanofibres for improved antibacterial activity

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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The anti-infection ability and skin regeneration are important aspects on the progress of wound healing, which needs an ideal wound dressing that not only resists bacteria but also promotes skin regeneration. In this study, zinc oxide/silver/polyvinylpyrrolidone/polycaprolactone (ZnO/Ag/PVP/PCL) nanofibres were prepared through electrospinning. Firstly, zinc oxide nanoparticles (ZnONPs) and silver nanoparticle (AgNPs) were synthesized respectively. Secondly, the two nanoparticles were mixed with polyvinylpyrrolidone (PVP) and polycaprolactone (PCL) to obtain the nanofibres. The results of scanning electron microscopy (SEM) showed that ZnONPs and AgNPs were 40.07 ± 9.70 nm and 37.46 ± 12.02 nm, respectively. After electrospinning, the nanofibres were 368.22 ± 123.96 nm in diameter. Infrared spectroscopy revealed that ZnONPs/AgNPs bimetallic nanomaterials were physically embedded in the nanofibres. The antibacterial effects against Staphylococcus aureus and Escherichia coli of ZnO/Ag/PVP/PCL nanofibres were significantly better than these of the single metal material-loaded nanofibres. More importantly, the combination of ZnO and Ag reduced the cytotoxicity of ZnO/Ag/PVP/PCL bimetallic nanofibres toward fibroblasts. These findings demonstrated that ZnO/Ag/PVP/PCL bimetallic nanofibres should be of greater interest than the single metal nanomaterial-loaded nanofibres in inhibiting growth of bacteria.

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“…Here we report the facile synthesis of in situ crosslinking bionanocomposite hydrogels which deliver antimicrobial Zn 2+ and have potential for wound healing applications [64][65][66][67][68][69][70]. The simple addition of extra components enables the inclusion of multiple drugs to treat wounds with various microbial populations (or indeed for patients with multiple co-morbidities).…”

Section: Discussionmentioning

confidence: 99%

In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications

Leone

Fırlak

Challen

et al. 2019

JFB

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In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing.

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Sodium alginate and gum acacia hydrogels of ZnO nanoparticles show wound healing effect on fibroblast cells

Cited by 200 publications

References 20 publications

High-water-absorbing calcium alginate fibrous scaffold fabricated by microfluidic spinning for use in chronic wound dressings

High-water-absorbing calcium alginate fibrous scaffold fabricated by microfluidic spinning for use in chronic wound dressings

Zinc oxide/silver bimetallic nanoencapsulated in PVP/PCL nanofibres for improved antibacterial activity

In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications

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