Social Influences on Nicotine-Related Behaviors

Pina, José Antonio López; Namba, Mark D.; Leyrer‐Jackson, Jonna M.; Cabrera-Brown, Gabriella; Gipson, Cassandra D.

doi:10.1016/bs.irn.2018.07.001

Cited by 10 publications

(11 citation statements)

References 138 publications

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“…In addition, there are a number of NMR genomewide association study studies that have found genomewide significant signals in CYP2A6 and in nearby genes, such as CYP2B6 , CYP2A7 , EGLN2 , and NUMBL , among others 42,43 . Although much of the variability in nicotine metabolic clearance is heritable, 7,44 the environment is also expected to exert some effects 7,45 …”

Section: Discussionmentioning

confidence: 99%

“… 42 , 43 Although much of the variability in nicotine metabolic clearance is heritable, 7 , 44 the environment is also expected to exert some effects. 7 , 45 …”

Section: Discussionmentioning

confidence: 99%

“…42,43 Although much of the variability in nicotine metabolic clearance is heritable, 7,44 the environment is also expected to exert some effects. 7,45 There are some limitations to the study design and results. We report that genetic and metabolism phenotype data was missing from some study participants.…”

Section: Discussionmentioning

confidence: 99%

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Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke

Schaefer

Avey

Todd

et al. 2021

Clinical Translational Sci

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Prevalence of smoking is higher in Alaska Native and American Indian (ANAI) populations living in Alaska than the general US population. Genetic factors contribute to smoking and cessation rates. The objective of this study was to compare CYP2A6 genetic variation and CYP2A6 enzyme activity toward nicotine in an ANAI population. ANAI (N = 151) people trying to quit smoking were recruited. DNA samples were genotyped for CYP2A6 variants *1X2A, *1B, *2, *4, *9, *10, *12, and *35. Multiple nicotine metabolites were measured in plasma and urine samples, including cotinine and 3′‐hydroxycotinine used to determine CYP2A6 activity (e.g., nicotine metabolite ratio [NMR]). We calculated summary statistics for all of the genotypes and metabolites and assigned CYP2A6 activity scores based on known information. We studied the association of CYP2A6 variants with the NMR and smoking histories. The overall frequency of the CYP2A6*1B gain of function allele was high in the ANAI versus non‐ANAI populations in other studies. Both *4 null and *9 decrease of function alleles had frequencies similar to previous studies of ANAI populations. In a multivariate analysis, the genotype‐inferred CYP2A6 activity score was associated with both plasma and urine NMR (p value = 8.56E‐08 and 4.08E‐13, respectively). Plasma NMR was also associated with duration of smoking (p value < 0.01) but not urinary total nicotine equivalents uncorrected for creatinine (TNE9uc) or biological sex. Urine NMR was significantly associated (p value < 0.01) with TNE9uc. Variation in NMR in this ANAI population is explained in part by CYP2A6 genetic variation.

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Section: Discussionmentioning

confidence: 99%

“… 42 , 43 Although much of the variability in nicotine metabolic clearance is heritable, 7 , 44 the environment is also expected to exert some effects. 7 , 45 …”

Section: Discussionmentioning

confidence: 99%

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Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke

Schaefer

Avey

Todd

et al. 2021

Clinical Translational Sci

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“…Ketergantungan terhadap nikotin serta kebiasaan merokok umumnya terkait dengan pengaruh sosial, baik dari hubungan keluarga maupun teman (Piña et al, 2018). Anak-anak yang sering terpapar oleh rokok di rumah, lebih mungkin untuk bereksperimen dengan rokok dibandingkan dengan anak tanpa paparan rokok (Barman et al, 2004;Farkas et al, 2014).…”

Section: Pembahasanunclassified

Hubungan antara Perilaku Merokok Anggota Rumah Tangga dengan Perilaku Merokok Remaja di Indonesia

Nainggolan¹,

Dharmayanti²,

Kristanto³

2020

hsr

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This study aimed to know the association and risk levels of household other members and adolescent smoking behaviors in Indonesia. As confounding variables of study involving Alcohol Consumption Behavior, Lived Area, and Social-Economics Status Variables. A study hypothesis declared that there was a signiﬁ cant correlation between smoking behavior of household other members as a smoker with the smoking behavior of 15 to 18 years old after being controlled by other variables. Furthermore, this study using a Basic Health Research Secondary Data of 2018 aged 15 until 18 years and a multivariable analyzed uses logistic regression. The results showed a signiﬁ cant correlation (p-value 0,000) between Household Other Members as a Smoker with smoking behavior of 15 to 18 years old after being controlled by confounding variables with OR 1,449 (95% CI 1,346-1,56-0). Smoker Variable not as a Head of Household was signiﬁ cantly correlated (p-value 0,007) with OR 2,002 (95% CI 1,211-3,377), Alcohol Consumption Behavior was signiﬁ cantly correlated (P-value 0,000) with OR 20,602 (95% CI 17,611-24,101), Lived Area with OR 1,129 (95% CI 1,051-1,212), also Social Economic Status with OR 1,098 (95%CI 1,024-1,178). An Alcohol Consumption Behavior Variable was the most dominant variable in determining Adolescent Smoking Behavior. We should focalize on areas identity is driven by health service providers, stakeholders, and policymakers. Accordingly, formulate awareness programs and education, particularly adolescents, to eliminate smoking initiation. Abstrak Penelitian ini bertujuan untuk mengetahui hubungan dan besaran risiko perilaku merokok anggota rumah tangga lain dengan perilaku merokok remaja berusia 15 sampai dengan 18 tahun di Indonesia. Variable perancu pada penelitian ini meliputi perilaku konsumsi alkohol, wilayah tempat tinggal, serta status sosial ekonomi responden. Hipotesis penelitian ini adalah ada hubungan yang bermakna antara perilaku merokok anggota rumah tangga lain sebagai perokok, dengan perilaku merokok remaja usia 15 sampai dengan 18 tahun setelah dikontrol oleh variabel lain. Penelitian ini menggunakan data sekunder Riset Kesehatan Dasar (Riskesdas) tahun 2018 dengan rentang usia 15-18 tahun dan data di analisis secara multivariabel menggunakan regresi logistik. Hasil penelitian diperoleh bahwa terdapat hubungan yang bermakna (p value 0,000) antara anggota rumah tangga lain sebagai perokok dengan dengan perilaku merokok pada remaja usia 15 sampai dengan 18 tahun setelah dikontrol oleh variabel perancu dengan OR 1,449 (95% CI 1,346-1,56-0). Variabel perokok bukan sebagai kepala rumah tangga berhubungan bermakna (p value 0,007) dengan OR 2,002 (95% CI 1,2113,377), perilaku minum alkohol berhubungan bermakna (p value 0,000) dengan OR 20,602 (95% CI 17,611-24,101), wilayah tempat tinggal responden dengan OR 1,129 (95% CI 1,051-1,212), serta status sosial ekonomi dengan OR 1,098 (95%CI 1,024-1,178). Variabel perilaku minum alkohol adalah variabel yang paling besar pengaruhnya terhadap perilaku merokok pada remaja. Perlu fokus identiﬁ kasi area oleh penyedia layanan kesehatan serta para stake holder pembuat kebijakan dalam merumuskan program kesadaran dan pendidikan khususnya pada remaja untuk eliminasi inisiasi merokok.

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“…More precisely in the Brazilian reality, the importance of studies on the social economy of health in line with theoretical and empirical findings in the specialized literature of the medical sciences is necessary, especially in dialogue with scientific trends in other national contexts (PIÑA et al, 2018). Brazilian stylized facts denote that smoking is associated with the development of various types of cancer, with 428 people dying each day due to direct dependence on nicotine, in addition to diseases caused by secondhand smoke (INCA, 2018).…”

Section: -Introductionmentioning

confidence: 99%

Peer smoking among brazilian adolescents: are the effects of social interaction in school classes relevant?

Júnior¹

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This research aims to analyze how smoking among young Brazilians is influenced or not by the effects of peers at the level of school classes (colleagues), weighted by individual characteristics, contextual to individuals and institutions in the school households surveyed. The contribution of this study is to fill an existing gap in the Brazilian literature, where the existence of drug use pairs in general is still little explored by empirical academic research in the area of health and social economy. The analytical and econometric approach taken here aggregates issues related to non-linear models of consumption choices and lagged social interaction effects, where the issue of causality is resolved with such empirical modeling. Using individual-level data from the 2012 and 2015 of Pesquisa Nacional de Saúde do Escolar, estimates were performed using a multinomial logit model and an additional series of models were estimated by inputting control variables, adolescent family background, effects of year and region to mitigate the biases of the social interaction effects of school classes, in addition to the temporal effect for the year 2012. The results found showed that increasing the proportion of peers in a smoking room increases the relative risks of be an occasional and regular user, for the model with all variables (RRR=2,501; 2,064); while for the lagged pair effect, the relative risks of being an occasional smoker decrease in the 2015 period (RRR=0.614; 0.493). The estimation of the various econometric models, where the other regressors are added gradually, showed a reduction in the relative risks of smoking occasionally and regularly, albeit in a discrete way and still being statistically significant to fully explain smoking. Keywords: Peer effects. Smoking. Health adolescents. Pseudo-panel. Social econometrics

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Social Influences on Nicotine-Related Behaviors

Cited by 10 publications

References 138 publications

Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke

Nicotine metabolism and its association with CYP2A6 genotype among Indigenous people in Alaska who smoke

Hubungan antara Perilaku Merokok Anggota Rumah Tangga dengan Perilaku Merokok Remaja di Indonesia

Peer smoking among brazilian adolescents: are the effects of social interaction in school classes relevant?

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