The present study examined the roles of work factors (i.e. job demands, job resources), workfamily conflicts and culture on predictors of healthy intentions (fruit and vegetable consumption, low-fat diet, physical activity) within the framework of the Theory of Planned Behaviour (TPB).Employees from the UK (N = 278) and Malaysia (N = 325) participated in the study. Results indicated that higher job demands were significantly related to lower intentions to eat a low-fat diet. Females reported higher intentions to eat a low-fat diet than males did, while participants from the UK had lower intentions to engage in physical activity compared to those from Malaysia. The efficacy of TPB variables in explaining intentions was verified, with perceived behavioural control (i.e. self-efficacy), attitudes and descriptive norms combined with past behaviour predictive across the samples. The results also suggest the roles of culture and work interference with family variables in moderating TPB-intention relationships and confirm that TPB variables mediate the effects of job demands and job resources on intentions. Practically, to promote health, identifying strategies to reduce stress factors; specifying important cognitive factors affecting work factors and thus, healthy intentions; and acknowledging cultural-specific determinants of healthy intentions are recommended.