Social cognition and face processing in schizophrenia

Hall, Jérémy; Harris, Jonathan M.; Sprengelmeyer, Reiner; Sprengelmeyer, Anke; Young, Andrew W.; Santos, Isabel M.; Johnstone, Eve C.; Lawrie, Stephen M.

doi:10.1192/bjp.185.2.169

Cited by 109 publications

(83 citation statements)

References 9 publications

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“…The available studies have focused on decisions related to threat, particularly judgements of approachability and trustworthiness from faces. There is evidence that approachability and trustworthiness judgements are abnormal in schizophrenia, an effect that may be more pronounced in paranoid individuals (Hall et al 2004 ;Baas et al 2008b ;Pinkham et al 2008). Similarly, individuals with ASD have also been shown to have impairments in rating approachability and trustworthiness from faces (Adolphs et al 2001), and in labelling complex emotions from images of eyes (Baron-Cohen et al 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Two tests of social cognition were performed comprising judgements of approachability or intelligence from faces (Hall et al 2004 ;Santos & Young, 2008). In the approachability task, participants had to decide whether faces appeared ' not approachable ' or ' very approachable '.…”

Section: Experimental Designmentioning

confidence: 99%

“…Patients with both disorders showed deficits in social judgement that were not restricted to affective, threat-related decisions (such as approachability) but extended to judgements of intelligence and distinctiveness from faces (Hall et al 2004 ;Philip et al in press). These results suggest that a common system underlying a wide range of social judgements from faces is disrupted in both schizophrenia and ASD (Brothers, 1990 ;Haxby et al 2000Haxby et al , 2002Adolphs, 2003 ;Brunet-Gouet & Decety, 2006 ;Amaral et al 2008 ;Pinkham et al 2008).…”

Section: Introductionmentioning

confidence: 99%

“…In previous work we have demonstrated deficits in patients with schizophrenia and ASD in making social judgement from faces using a battery of tests covering a range of different social dimensions (Hall et al 2004 ;Philip et al in press). Patients with both disorders showed deficits in social judgement that were not restricted to affective, threat-related decisions (such as approachability) but extended to judgements of intelligence and distinctiveness from faces (Hall et al 2004 ;Philip et al in press).…”

Section: Introductionmentioning

confidence: 99%

“…In the current study we investigated the neural basis of social judgements for both overtly affective, threat-related social judgements (judgements of approachability) and social judgements that do not relate directly to the evaluation of physical threat (judgements of intelligence), both of which are impaired in schizophrenia and ASD (Hall et al 2004 ;Philip et al in press). We investigated the basis of such judgements in healthy control subjects to help elucidate the neural basis of the cognitive function disturbed in neuropsychiatric disorders such as schizophrenia and ASD, while avoiding the potential confounds of scanning studies of individuals with these disorders (such as differential task performance).…”

Section: Introductionmentioning

confidence: 99%

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A common neural system mediating two different forms of social judgement

et al. 2009

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Background. A wide range of neuropsychiatric conditions, including schizophrenia and autistic spectrum disorder (ASD), are associated with impairments in social function. Previous studies have shown that individuals with schizophrenia and ASD have deficits in making a wide range of social judgements from faces, including decisions related to threat (such as judgements of approachability) and decisions not related to physical threat (such as judgements of intelligence). We have investigated healthy control participants to see whether there is a common neural system activated during such social decisions, on the basis that deficits in this system may contribute to the impairments seen in these disorders.Method. We investigated the neural basis of social decision making during judgements of approachability and intelligence from faces in 24 healthy participants using functional magnetic resonance imaging (fMRI). We used conjunction analysis to identify common brain regions activated during both tasks.Results. Activation of the amygdala, medial prefrontal cortex, inferior prefrontal cortex and cerebellum was seen during performance of both social tasks, compared to simple gender judgements from the same stimuli. Task-specific activations were present in the dorsolateral prefrontal cortex in the intelligence task and in the inferior and middle temporal cortex in the approachability task.Conclusions. The present study identified a common network of brain regions activated during the performance of two different forms of social judgement from faces. Dysfunction of this network is likely to contribute to the broad-ranging deficits in social function seen in psychiatric disorders such as schizophrenia and ASD.

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