Social behavior, dominance, and social deprivation of rats determine drug choice

Wolffgramm, Jochen; Heyne, Andrea

doi:10.1016/0091-3057(91)90297-f

Cited by 135 publications

(131 citation statements)

References 40 publications

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“…Lesscher et al (2010) used a limited access choice paradigm in mice. Resonating well with the findings of Wolfgramm (1991) and Wolffgramm and Heyne (1991), these mice readily escalated their alcohol intake and also became insensitive to quinine. Remarkably, this was apparent when the devalued solution was the only source of alcohol for the mice (i.e., the choice was between alcohol+quinine and water) after only 2 weeks of alcohol experience.…”

Section: Resistance To Punishmentmentioning

confidence: 61%

“…In their pioneering studies on the development of alcohol addiction in rats, Wolffgramm (1991) and Wolffgramm and Heyne (1991), not only demonstrated escalation of intake, they also observed resistance to punishment in the form of insensitivity to quinine. That is, the rats that showed elevated levels of alcohol intake also displayed a smaller reduction of alcohol intake when the solution was made bitter with quinine.…”

Section: Resistance To Punishmentmentioning

confidence: 99%

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Compulsive drug use and its neural substrates

Lesscher

Vanderschuren²

2012

Reviews in the Neurosciences

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Drug addiction is a chronic relapsing brain disease, characterized by compulsive drug use. Despite the fact that drug addiction affects millions of people worldwide, treatments for this disorder are limited in number and efficacy. In our opinion, understanding the neural underpinnings of drug addiction would open new avenues for the development of innovative treatments for this disorder. Based on an awareness that drug use and drug reward do not equal drug addiction, there has been increasing interest in developing animal models of addiction that mimick the loss of control over drug use more closely than existing models aimed at studying drug reward. The present review provides an overview of animal studies of compulsive drug use and the neural mechanisms involved. First, the employed models are summarized, with a particular emphasis on models of escalation of drug use and resistance to punishment. Next, we discuss mechanisms within the (ventral and dorsal) striatum and (central) amygdala that have recently been implicated in the compulsive seeking and taking of alcohol and cocaine. The studies discussed here provide a promising line of research that will advance our knowledge of the neural circuits involved in the self-destructive behavior that characterizes drug addiction.

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Section: Resistance To Punishmentmentioning

confidence: 61%

Section: Resistance To Punishmentmentioning

confidence: 99%

Compulsive drug use and its neural substrates

Lesscher

Vanderschuren²

2012

Reviews in the Neurosciences

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“…To date, the majority of preclinical research investigating the impact of social and environmental enrichment on ethanol and sucrose consumption has been directed toward ethanol consumption (see Tables 1 and 2). While there is considerable methodological variation between the models used in these studies (species, strain, ethanol concentration, type and length of ethanol access), they generally show that social deprivation (individual rather than group housing) increases ethanol consumption (Lodge & Lawrence, 2003;Schenk, Gorman, & Amit, 1990;Wolffgramm, 1990;Wolffgramm & Heyne, 1991). The role of other types of environmental enrichment designed to provide physical and/or cognitive stimulation is less clear.…”

mentioning

confidence: 99%

Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice

et al. 2017

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“…The stimulating effects of direct proximal social interactions on ethanol intake have also been reported in a number of rodent species, including rats [6,7,8,9,10,11,12,13], mice [14,15,16], and prairie voles [17,18]. It should be noted that several early investigations employing animal subjects evaluated the effects of social stimulation by comparing ethanol consumption in isolation-housed versus group-housed rodents, and found little evidence of social stimulation of ethanol drinking [7,8,16,19,20].…”

Section: Introductionmentioning

confidence: 99%

“…It should be noted that several early investigations employing animal subjects evaluated the effects of social stimulation by comparing ethanol consumption in isolation-housed versus group-housed rodents, and found little evidence of social stimulation of ethanol drinking [7,8,16,19,20]. In their group-housing arrangements, more than one subject was placed in a cage, allowing for direct physical contact among members of the group.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Proximal and Distal Social Stimulation on Ethanol Intake in Male and Female CD-1 Mice

Tomie¹,

Samuel

Merchant

et al. 2016

J Drug Alcohol Res

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Background. Proximal and distal social stimulation increase ethanol drinking in humans. Purpose. Our study evaluated the effects of proximal and distal social stimulation on home-cage ethanol drinking in mice. Study design. Proximal cagemate drinking (PCD) procedures use a clear plastic barrier to separate the drinker mouse from the proximal cagemate mouse, to evaluate home-cage drinking of 10% ethanol and water. Eight groups of CD-1 mice were arranged in a 2 × 2 × 2 factorial design with two levels of sex of drinker (male vs. female), two levels of sex of cagemate (male vs. female), and two levels of distal group-housed mice in the colony room (present vs. absent). Results. Distal group-housed mice, located outside of the home cage, stimulated ethanol drinking in female drinkers and did so regardless of the sex of their proximal cagemate. This effect was observed in the male drinker but only when housed with a proximal male cagemate. Conclusion. This study provides the first report of distal social stimulation of ethanol drinking in mice. The distal social stimulation effect, like the effects of proximal social stimulation, was more pronounced in female drinkers.

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Social behavior, dominance, and social deprivation of rats determine drug choice

Cited by 135 publications

References 40 publications

Compulsive drug use and its neural substrates

Compulsive drug use and its neural substrates

Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice

The Effects of Proximal and Distal Social Stimulation on Ethanol Intake in Male and Female CD-1 Mice

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