Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice

Holgate, Joan; Garcia, Hilary; Chatterjee, Susmita; Bartlett, Selena E.

doi:10.1002/brb3.767

Cited by 48 publications

(40 citation statements)

References 101 publications

(102 reference statements)

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“…Another limitation that the singlehoused animal model can face is handling by the researcher that produces experimental variations [12,20]. A recent study has shown that single-housed mice consume more alcohol in comparison with grouphoused animals [21]. However, in this study mice were given 20% ethanol without preliminary alcohol habituation.…”

Section: Discussionmentioning

confidence: 93%

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Towards developing a model to study alcohol drinking and craving in female mice housed in automated cages

Koskela

Piepponen

Andressoo

et al. 2018

Behavioural Brain Research

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It is about half a century ago when the so-called "Wise model" to study alcohol drinking behavior in rats was established. The model was based on voluntary intermittent access to increasing concentrations of alcohol. We aimed to establish a model of alcohol craving and used an extinction test on withdrawal days 1 and 10 to study motivation for alcohol. For this purpose, the alcohol drinking training was paired with light cues to establish conditioning. The extinction test was carried out without alcohol but in the presence of light cues and empty bottles. The outcome measures were number of visits, nosepokes, and licks in the conditioned corner where the number of nosepokes represents how much mice "want" alcohol and number of licks shows how much mice "like" alcohol. The number of nosepokes during withdrawal is a measure of craving. Late withdrawal craving was found when intermittent alcohol access was carried out in the automated cages. In this case, we observed a significant increase in the number of nosepokes on both withdrawal days 1 and 10 as compared to water control. The number of nosepokes in the withdrawal days did not correlate with alcohol dose, but number of nosepokes on withdrawal day 1 correlated with the number of nosepokes on the last training day. Although we did not observe incubation of alcohol craving after withdrawal, the craving was increased at the late time point. We conclude that we have established a new tool to study alcohol drinking behavior and craving in female mice.

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Section: Discussionmentioning

confidence: 93%

“…In these elegant studies, that include a social context and minimal human interference, similar alcohol consumption is reported [14,21,[28][29][30]. However, these studies have not focused on cue-induced craving after withdrawal.…”

Section: Accepted Manuscriptmentioning

confidence: 90%

Towards developing a model to study alcohol drinking and craving in female mice housed in automated cages

Koskela

Piepponen

Andressoo

et al. 2018

Behavioural Brain Research

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“…This is contrary to later anxiolytic effects of enrichment on adolescent exposure to methamphetamine (Peterson and Hughes, 2017) and acute administration in adulthood of scopolamine (Hughes and Otto, 2013). It is also inconsistent with reductions in the reinforcing value and thus addiction potential of other drugs such as heroin (El Rawas et al, 2009), cocaine (Solinas et al, 2008) and ethanol (Holgate et al, 2017). However, there are also examples of enrichment having the opposite effect such as increasing ethanol's reinforcing value (Berardo et al, 2016) thereby detracting from any perceived beneficial quality of the manipulation.…”

Section: Discussionmentioning

confidence: 99%

“…However, enrichment can influence drug effects in different ways. For example, it has been shown to either increase voluntary consumption and the reinforcing value of ethanol in rats (Berardo et al, 2016; Rockman et al, 1989) and mice (Rae et al, 2018), or have the opposite effect in both species respectively (Deehan et al, 2007; Holgate et al, 2017). It was therefore conceivable that BZP experienced repeatedly during adolescence in conjunction with enrichment might also differ in its subsequent effects on anxiety‐related behavior from those following acute administration of other drugs during adulthood.…”

Section: Introductionmentioning

confidence: 99%

Treatment with 1‐benzylpiperazine (BZP) during adolescence of male and female hooded rats exposed to environmental enrichment: Subsequent behavioral outcomes

Dixon

Hughes²

2018

Intl J of Devlp Neuroscience

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From 30 days after birth until the completion of the study, male and female rats were caged in same‐sexed twos or threes either with (enriched cages, EC) or without several objects for them to explore (standard cages, SC). From 41 to 50 days of age (late adolescence), they received a daily intraperitoneal injection of saline, or 10 or 20 mg/kg of the monoaminergic agonist drug of abuse, 1‐benzylpiperazine (BZP). Ten days later (PND60+), their behavior was observed over several days in an open field, an elevated plus maze, a light‐dark box and (to assess short‐term memory) a Y maze in which one of the arms had been changed in brightness between two trials. These tests were repeated from 40 days after PND60+, namely PND100+. While open‐arm occupancy at PND100+ in the plus maze was lower following both doses of the drug for SC rats only, other examples of BZP‐related heightened anxiety were confined to EC rats. This suggested that enrichment had enhanced rather than reduced any anxiogenic effects of the drug treatment. There was no plausible evidence of BZP‐associated impaired spatial memory required to recognize the changed novel Y‐maze arm. Instead, changes in novelty preferences or neophobia‐related anxiety were most likely. While there were also some examples of sex and age differences in the later effects of BZP, in most cases these were evident at both ages following treatment with both BZP doses. A number of overall BZP, cage, sex and age differences, independent of enrichment effects, were also observed.

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“…social isolation stress, chronic variable stress) can increase adult ethanol intake (e.g. [103][104][105][106][107], see also reviews: [108,109]). Elevated ethanol intake in other neurodevelopmental models may be linked to molecular changes such as decreased firing of dopaminergic VTA neurons in an LPS model [103], and may be related to altered anxiety-like states, as ethanol consumption in two-bottle free choice can be reduced by administration of anxiolytic adrenergic drugs [105].…”

Section: Ethanolmentioning

confidence: 99%

Schizophrenia and drug addiction comorbidity: recent advances in our understanding of behavioural susceptibility and neural mechanisms

Menne

Chesworth

2020

Neuroanatomy and Behaviour

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Schizophrenia is a severe psychiatric disorder which is worsened substantially by substance abuse/addiction. Substance abuse affects nearly 50% of individuals with schizophrenia, extends across several drug classes (e.g. nicotine, cannabinoids, ethanol, psychostimulants) and worsens overall functioning of patients. Prominent theories explaining schizophrenia and addiction comorbidity include the primary addiction hypothesis (i.e. schizophrenia susceptibility primes drug reward circuits, increasing drug addiction risk following drug exposure), the two-hit hypothesis (i.e. drug abuse and other genetic and/or environmental risk factors contribute to schizophrenia development) and the self-medication hypothesis (i.e. drug use alleviates schizophrenia symptoms). Animal models can be used to evaluate the utility and validity of these theories. Since this literature was last reviewed by Ng and colleagues in 2013 [Neurosci Biobehav Rev, 37(5)], significant advances have been made to our understanding of schizophrenia and substance abuse comorbidity. Here we review advances in the field since 2013, focussing on two key questions: 1) Does schizophrenia susceptibility increase susceptibility to drug addiction (assessing the primary addiction hypothesis), and 2) Do abused drugs exacerbate or ameliorate schizophrenia symptoms (assessing the two-hit hypothesis and the self-medication hypothesis). We addressed these questions using data from several schizophrenia preclinical models (e.g. genetic, lesion, neurodevelopmental, pharmacological) across drug classes (e.g. nicotine, cannabinoids, ethanol, psychostimulants). We conclude that addiction-like behaviour is present in several preclinical schizophrenia models, and drugs of abuse can exacerbate but also ameliorate schizophrenia-relevant behaviours. These behavioural changes are associated with altered receptor system function (e.g. dopaminergic, glutamatergic, GABAergic) critically implicated in schizophrenia and addiction pathology.

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Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice

Abstract: Background: Factors leading to the harmful consumption of substances, like alcohol

Cited by 48 publications

References 101 publications

Towards developing a model to study alcohol drinking and craving in female mice housed in automated cages

Towards developing a model to study alcohol drinking and craving in female mice housed in automated cages

Treatment with 1‐benzylpiperazine (BZP) during adolescence of male and female hooded rats exposed to environmental enrichment: Subsequent behavioral outcomes

Schizophrenia and drug addiction comorbidity: recent advances in our understanding of behavioural susceptibility and neural mechanisms

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