SNEDDS (SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM) FORMULATION OF -CAROTENE IN OLIVE OIL (Olea europaea)

Wulandari, Erna; Alverina, AdellaClara; Martien, Ronny

doi:10.21474/ijar01/2179

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…The increasing transmittance response of the SNEDDS was supported by Tween 80 (B) and PEG 400 (C); while the Miglyol (A) reduced the transmittance response (Table II.B). This is in line with the fact that increasing oil concentration will decrease the transmittance due to its larger droplet size (Wulandari et al, 2016). Different from the transmittance response; the lesser the value of emulsifying time the faster the time for emulsifying, which means the better the SNEDDS formula.…”

Section: Resultssupporting

confidence: 53%

Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study

2020

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Essential oil of Curcuma mangga Val. has been reported to have cytotoxic effect against cancer cell lines. But this oil is unstable in dispensing so that a self nano-emulsifying drug delivery system (SNEDDS) of the oil was conducted to solve the problem and improve its potency. In the study, optimization, verification, characterization, and stability test of the SNEDDS formula were carried out respectively by simplex lattice design (SLD) on Design Expert ver. 10 software, droplet size and Zeta potential determinations using particle size analyzer (PSA) instrument, as well as heating-cooling and freeze-thaw methods. The best SNEDDS formula resulted was Miglyol : Tween 80 : PEG 400 = 16.034% : 68.380% : 15.586%; with transmittance of 84.47 + 1.05%, droplet size of 15.75 nm, zeta potential of -8.54 mV, polydispersity index (PDI) of 0.188, emulsifying time of 49.67 + 1.7 seconds in distilled water, 24.33 + 4.19 seconds in artificial gastric fluid and 21.33 + 2.87 seconds in artificial intestine fluid. After a freeze-thaw test there was no change on the emulsion’s clarity, color, smell, as well as no separation, which means that the formula was stable thermodynamically. The optimum SNEDDS formula resulted has small particle size, better emulsifying time in artificial gastric and intestine fluids, as well as better thermodynamic stability, which in turn will improve the cytotoxic activity of the Curcuma mangga Val. rhizome oil toward cancer cells.

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Section: Resultssupporting

confidence: 53%

Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study

2020

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“…Alpha-Bisabolol was mixed with Virgin Coconut Oil, added Alkamuls® CRH 40 and PEG 400, then homogenized with a magnetic stirrer for 10 min followed by sonication for 15 min and conditioned on a water bath at 40 °C for 10 min. The results of SNEDDS Alpha-Bisabolol were measured transmittance percent at 650 nm wavelength and determined the optimum SNEDDS formula [6].…”

Section: Alpha-bisabolol Snedds Optimizationmentioning

confidence: 99%

“…A much of 0.1 ml of optimum SNEDDS was dissolved in 10 ml of distilled water. Then it was homogenized with a magnetic stirrer at room temperature and the time to reach emulsification was calculated using a stopwatch [6].…”

Section: Dispersibility Testmentioning

confidence: 99%

Formulation Gel Self Nanoemulsifying Drug Delivery System (Snedds) Alpha-Bisabolol as Antioxidant

RAMADHAN

NOOR

2022

Int J App Pharm

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Objective: Alpha-Bisabolol is monocyclic sesquiterpene alcohol obtained from the distillation of chamomile flowers (Matricaria chamomilla), that has many uses in the pharmaceutical industry, one of them is an antioxidant. Alpha-Bisabolol was formulated into Self Nanoemulsifying Drug Delivery System (SNEDDS) to protect it from oxidation reactions in skin metabolism and to help penetrate it to the dermis layer where it works. The purpose of this study is to develop the use of Alpha-Bisabolol as an antioxidant that is formulated into SNEDDS gel dosage form. Optimization of SNEDDS was carried out on four formulas with a different comparison of surfactant and use of percent transmittance as the parameter. Methods: Optimum SNEDDS is then tested for characterization, including dispersibility test, particle size, polydispersity index (PDI), zeta potential, and freeze-thaw cycle. The result for SNEDDS optimization shows that formula 4 produces the highest percent transmittance of 99.44±0.04%. Results: Optimum formula that was characterized resulting clear nanoemulsion with an emulsification time 29.64±0.09 second, with the particle size of 16.74 nm, PDI of 0.121, and zeta potential of-18.7 mV also shows good stability after freeze-thaw cycle test for three cycles. Optimum SNEDDS then formulate to gel form. Based on the result of the physical and chemical quality evaluation test for Alpha-Bisabolol SNEDDS gel, it was found that SNEDDS gel was homogeneous with a clear yellowish appearance, odorless with semi-solid form, had viscosity 180±2 cP with plastic thixotropy flow properties, spreadability 2937.7691±2.40 mm2 and pH 5.55±0.015. Conclusion: It can be concluded that Alpha-Bisabolol and SNEDDS Alpha-Bisabolol gel have antioxidant activity with IC50 of 123.78 g/ml and 371.44 g/ml, respectively.

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“…Table 6 summarizes some of the research work related to SEDDS development by the application of DoE concept. [18][19][20][21][22][23][24][25][26][27]…”

Section: Risk Assessmentmentioning

confidence: 99%

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Kavitha¹

2020

AJP

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In recent years, drug discovery studies show that more than 40% of new drugs synthesized are having poor aqueous solubility rendering them poorly bioavailable after oral administration. Self-emulsifying drug delivery systems (SEDDS) are the novel lipid-based formulations having the potential to enhance the oral bioavailability of poorly water-soluble drugs which belong to class II and IV of the biopharmaceutical classification system. SEDDS is the isotropic mixtures of oil, surfactant, cosurfactant, and sometimes cosolvent. The presence of surfactant enhances the membrane permeability, whereas medium-and long-chain triglyceride oils promote the lymphatic absorption of the drug. The better performance of SEDDS in terms of improvement in solubility and permeability characteristics has rapidly introduced many SEDDS products into the market and many others in the clinical development phase. Quality by design (QbD) is a regulatory-driven approach, which adopts a multitude of techniques in product development, which lends a controlled and reproducible result, thereby resulting in a formulation which could meet the therapeutic goals. The complexities of the SEDDS formulation and the ingredients involved in the design of experiment and risk assessment techniques based on QbD methodologies are increasingly used in the formulation development of SEDDS. This review provides a summary of the systematic application of QbD concepts in the development of SEDDS for poorly bioavailable drugs.

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SNEDDS (SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM) FORMULATION OF -CAROTENE IN OLIVE OIL (Olea europaea)

Cited by 8 publications

References 12 publications

Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study

Self Nano-Emulsifying Drug Delivery System (SNEDDS) of Curcuma Mangga Val. Essential Oil and The Stability Study

Formulation Gel Self Nanoemulsifying Drug Delivery System (Snedds) Alpha-Bisabolol as Antioxidant

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