Formulation Gel Self Nanoemulsifying Drug Delivery System (Snedds) Alpha-Bisabolol as Antioxidant

Abstract

Objective: Alpha-Bisabolol is monocyclic sesquiterpene alcohol obtained from the distillation of chamomile flowers (Matricaria chamomilla), that has many uses in the pharmaceutical industry, one of them is an antioxidant. Alpha-Bisabolol was formulated into Self Nanoemulsifying Drug Delivery System (SNEDDS) to protect it from oxidation reactions in skin metabolism and to help penetrate it to the dermis layer where it works. The purpose of this study is to develop the use of Alpha-Bisabolol as an antioxidant that is formulated into SNEDDS gel dosage form. Optimization of SNEDDS was carried out on four formulas with a different comparison of surfactant and use of percent transmittance as the parameter.
 Methods: Optimum SNEDDS is then tested for characterization, including dispersibility test, particle size, polydispersity index (PDI), zeta potential, and freeze-thaw cycle. The result for SNEDDS optimization shows that formula 4 produces the highest percent transmittance of 99.44±0.04%.
 Results: Optimum formula that was characterized resulting clear nanoemulsion with an emulsification time 29.64±0.09 second, with the particle size of 16.74 nm, PDI of 0.121, and zeta potential of-18.7 mV also shows good stability after freeze-thaw cycle test for three cycles. Optimum SNEDDS then formulate to gel form. Based on the result of the physical and chemical quality evaluation test for Alpha-Bisabolol SNEDDS gel, it was found that SNEDDS gel was homogeneous with a clear yellowish appearance, odorless with semi-solid form, had viscosity 180±2 cP with plastic thixotropy flow properties, spreadability 2937.7691±2.40 mm2 and pH 5.55±0.015.
 Conclusion: It can be concluded that Alpha-Bisabolol and SNEDDS Alpha-Bisabolol gel have antioxidant activity with IC50 of 123.78 g/ml and 371.44 g/ml, respectively.