Sneak peek of Hypericum perforatum L.: phytochemistry, phytochemical efficacy and biotechnological interventions

Mir, Mohammad Yaseen; Hamid, Saima; Kamili, Azra N.; Hassan, Qazi P.

doi:10.1007/s13562-019-00490-7

Cited by 26 publications

(20 citation statements)

References 117 publications

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“…ROS brings about the peroxidation of membrane lipids, which leads to membrane damage [13,27]. Some studies report that induction of oxidative stress has been observed in plants exposed to MJ and SA [36][37][38]. In agreement with these early studies, exposure to MJ significantly increased the MDA content, an index of lipid peroxidation.…”

Section: Oxidative Stress-induced By Methyl Jasmonatesupporting

confidence: 66%

Methyl Jasmonate Induced Oxidative Stress and Accumulation of Secondary Metabolites in Plant Cell and Organ Cultures

Murthy

Park

2020

IJMS

166

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Recently, plant secondary metabolites are considered as important sources of pharmaceuticals, food additives, flavours, cosmetics, and other industrial products. The accumulation of secondary metabolites in plant cell and organ cultures often occurs when cultures are subjected to varied kinds of stresses including elicitors or signal molecules. Application of exogenous jasmonic acid (JA) and methyl jasmonate (MJ) is responsible for the induction of reactive oxygen species (ROS) and subsequent defence mechanisms in cultured cells and organs. It is also responsible for the induction of signal transduction, the expression of many defence genes followed by the accumulation of secondary metabolites. In this review, the application of exogenous MJ elicitation strategies on the induction of defence mechanism and secondary metabolite accumulation in cell and organ cultures is introduced and discussed. The information presented here is useful for efficient large-scale production of plant secondary metabolites by the plant cell and organ cultures.

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Section: Oxidative Stress-induced By Methyl Jasmonatesupporting

confidence: 66%

Methyl Jasmonate Induced Oxidative Stress and Accumulation of Secondary Metabolites in Plant Cell and Organ Cultures

Murthy

Park

2020

IJMS

166

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“…Yesaghi (2006) studied three habitats in Iran and determined that carbon and N-rich soil provided more suitable conditions for the vegetative growth of H. perforatum. Kuo et al (2020) and Mir al. (2019) reported a positive correlation between hyperforin content and soil organic carbon and N. Furthermore, the increasing altitude from 1400 to 2800 m led to an increase in hyperforin content from 24 to 27 mg/g, respectively,…”

Section: Discussionmentioning

confidence: 96%

“…Yesaghi ( 2006 ) studied three habitats in Iran and determined that carbon and N‐rich soil provided more suitable conditions for the vegetative growth of H. perforatum . Kuo et al ( 2020 ) and Mir et al ( 2019 ) reported a positive correlation between hyperforin content and soil organic carbon and N. Furthermore, the increasing altitude from 1400 to 2800 m led to an increase in hyperforin content from 24 to 27 mg/g, respectively, which is inconsistent with the results of Walker et al ( 2001 ), Kleemann et al ( 2014 ) and Xenophontos et al ( 2008 ) who understood there wasn't any significant difference in amount of hyperforin and hypericin in different altitudes. Altitude is well known factor that can significantly impact secondary metabolism and cause variation in quality and quantity of major essential oil components of H. perforatum (Seyis et al, 2020 ).…”

Section: Discussionmentioning

confidence: 98%

A comparison of artificial intelligence techniques for predicting hyperforin content in Hypericum perforatum L. in different ecological habitats

Saffariha

Jahani²,

Jahani

2021

Plant Direct

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Hyperforin, a major bioactive constituent of Hypericum concentration, is impacted by various phenological phases and soil characteristics. We aimed to design a model predicting hyperforin content in Hypericum perforatum based on different ecological and phenological conditions. We employed artificial intelligence modeling techniques including multilayer perceptron (MLP), radial basis function (RBF), and support vector machine (SVM) to examine the factors critical in predicting hyperforin content. We found that the MLP model (R2 = .9) is the most suitable and precise model compared with RBF (R2 = .81) and SVM (R2 = .74) in predicting hyperforin in H. perforatum based on ecological conditions, plant growth, and soil features. Moreover, phenological stages, organic carbon, altitude, and total N are detected in sensitivity analysis as the main factors that have a considerable impact on hyperforin content. We also report that the developed graphical user interface would be adaptable for key stakeholders including producers, manufacturers, analytical laboratory managers, and pharmacognosists.

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“…The characteristic compounds accumulated in H. perforatum are the naphthodianthrones hypericin and pseudohypericin [ 22 ]. Another important group is the flavonoids, which are phenolic secondary metabolites synthesized by a combination of the phenylpropanoid and polyketid pathways, and conjugated to sugars, e.g., glucose, rhamnose and rutinose.…”

Section: Introductionmentioning

confidence: 99%

“…The flavonoids include flavones, flavonols (quercetin, kaempferol), and glycosides (rutin, hyperside, and isoquercitrin). Other phenolic compounds, such as caffeic acids and chlorogenic acids, also accumulate in H. perforatum [ 22 ]. Secondary compounds accumulate in different plant organs [ 23 ], and some of these compounds are exuded by the root system into the rhizosphere [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Decoupling of Plant Growth and Accumulation of Biologically Active Compounds in Leaves, Roots, and Root Exudates of Hypericum perforatum L. by the Combination of Jasmonate and Far-Red Lighting

2021

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The plant hormone jasmonic acid (JA) fine tunes the growth–defense dilemma by inhibiting plant growth and stimulating the accumulation of secondary compounds. We investigated the interactions between JA and phytochrome B signaling on growth and the accumulation of selected secondary metabolites in Hypericum perforatum L., a medically important plant, by spraying plants with methyl jasmonate (MeJA) and by adding far-red (FR) lighting. MeJA inhibited plant growth, decreased fructose concentration, and enhanced the accumulation of most secondary metabolites. FR enhanced plant growth and starch accumulation and did not decrease the accumulation of most secondary metabolites. MeJA and FR acted mostly independently with no observable interactions on plant growth or secondary metabolite levels. The accumulation of different compounds (e.g., hypericin, flavonols, flavan-3-ols, and phenolic acid) in shoots, roots, and root exudates showed different responses to the two treatments. These findings indicate that the relationship between growth and secondary compound accumulation is specific and depends on the classes of compounds and/or their organ location. The combined application of MeJA and FR enhanced the accumulation of most secondary compounds without compromising plant growth. Thus, the negative correlations between biomass and the content of secondary compounds predicted by the growth-defense dilemma were overcome.

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Sneak peek of Hypericum perforatum L.: phytochemistry, phytochemical efficacy and biotechnological interventions

Cited by 26 publications

References 117 publications

Methyl Jasmonate Induced Oxidative Stress and Accumulation of Secondary Metabolites in Plant Cell and Organ Cultures

Methyl Jasmonate Induced Oxidative Stress and Accumulation of Secondary Metabolites in Plant Cell and Organ Cultures

A comparison of artificial intelligence techniques for predicting hyperforin content in Hypericum perforatum L. in different ecological habitats

Decoupling of Plant Growth and Accumulation of Biologically Active Compounds in Leaves, Roots, and Root Exudates of Hypericum perforatum L. by the Combination of Jasmonate and Far-Red Lighting

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