Smoking influences salivary histamine levels in periodontal disease

Bertl, Kristina; Haririan, Hady; Laky, Markus; Matĕjka, M; Andrukhov, Oleh; Rausch‐Fan, Xiaohui

doi:10.1111/j.1601-0825.2011.01891.x

Cited by 11 publications

(8 citation statements)

References 63 publications

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“…Most of the studies focused on biomarkers, which hold a potential diagnostic significance relevant to three important biological phases of periodontal disease, i.e., well-known markers C-reactive protein, IL-1β, IL-6, TNF-α involved in inflammatory phase; matrix metalloproteinases (MMP-8 and MMP-9) in connective-tissue degradation phase and alkaline phosphatase, receptor activator of NF-κB ligand, and osteoprotegerin in bone-turnover phase (for review, see Miller et al, 2010 ). Moreover, our previous studies demonstrate other biomolecules such as histamine, chromogranin A (CgA), melatonin, and nitric oxide derivatives to be related to the periodontal bacterial load and severity of periodontitis, as well as some of them were restored by a non-surgical therapy and influenced by smoking and gender (Bertl et al, 2012 , 2013 ; Haririan et al, 2012 ; Andrukhov et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Total Antioxidant Capacity and Total Oxidant Status in Saliva of Periodontitis Patients in Relation to Bacterial Load

Zhang

Andrukhov

Haririan

et al. 2016

Front. Cell. Infect. Microbiol.

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The detection of salivary biomarkers has a potential application in early diagnosis and monitoring of periodontal inflammation. However, searching sensitive salivary biomarkers for periodontitis is still ongoing. Oxidative stress is supposed to play an important role in periodontitis progression and tissue destruction. In this cross-sectional study, we investigated total antioxidant capacity (TAC) and total oxidant status (TOS) in saliva of periodontitis patients compared to healthy controls and their relationship with periodontopathic bacteria and periodontal disease severity. Unstimulated saliva was collected from 45 patients with generalized severe periodontitis and 37 healthy individuals and the TAC/TOS were measured. In addition, salivary levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Fusobacterium nucleatum in saliva were measured. Salivary TAC was lower in periodontitis patients compared to healthy controls. Moreover, a significant negative correlation of salivary TAC with clinical attachment loss was observed in periodontitis patients. No significant difference in the salivary TOS was observed between periodontitis patients and healthy controls. Bacterial load was enhanced in periodontitis patients and exhibited correlation with periodontal disease severity but not with salivary TAC/TOS. Our data suggest that changes in antioxidant capacity in periodontitis patients are not associated with increased bacterial load and are probably due to a dysregulated immune response.

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Section: Discussionmentioning

confidence: 99%

Total Antioxidant Capacity and Total Oxidant Status in Saliva of Periodontitis Patients in Relation to Bacterial Load

Zhang

Andrukhov

Haririan

et al. 2016

Front. Cell. Infect. Microbiol.

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“…Biomarker analysis is dependent on many factors, like the collection system, the individual salivary flow rate (66), stimulated or unstimulated sampling, time of sampling, centrifugation and processing, the storage of samples, and the detection method. Furthermore, aggravating factors for periodontitis such as smoking (67)(68)(69) or stress, but also gender have a locally or systemically influence on the secretion of biomarkers into saliva (66,70,71). It was also shown that blood contamination of saliva samples could have an impact on biomarker levels (72).…”

Section: Influencing Factors On Salivary Biomarkersmentioning

confidence: 99%

Saliva as a Source of Biomarkers for Periodontitis and Periimplantitis

et al. 2021

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Saliva has the potential to be used as a diagnostic and monitoring tool for various diseases if biomarkers of an adequate sensitivity and specificity could be identified. Several reviews and even meta-analyses have been performed in recent years, which have found some candidate biomarkers for periodontitis, like macrophage inflammatory protein-1 alpha, interleukin-1ß, interleukin-6, matrix metalloproteinase-8, or hemoglobin. However, none of those are currently in use to replace conventional periodontal diagnostics with a periodontal probe. For periimplantitis, to date, heterogeneity of different study protocols and implant types did not permit to discover clear biomarkers, which were able to distinguish between healthy and diseased implants. Few proinflammatory cytokines, similar to periodontitis, have been characterized as adjunct tools to clinical diagnosis. The additional determination of antimicrobial peptides, bone turnover markers, and bacteria could help to enhance sensitivity and specificity in a combined model for periodontitis and periimplantitis. Furthermore, proteomic approaches might be preferred over single biomarker determinations. A global consensus is also needed to harmonize salivary sampling methods as well as procedures of biomarker analysis to ensure future comparability.

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“…Nicotine affects gingival blood flow, cytokine production, neutrophil and other immune cell function, as well as connective tissue turnover, all of which can be responsible for overall effects on periodontal tissues (22,23). Furthermore, involvement of salivary differed histamine and increased salivary calcium in smokers exacerbates PD (24,25). Antioxidant agents may overcome this impairment and may attenuate disease progression by down regulating glutathione detoxification / redox buffering system and by inhibiting key transcription factors, which lead to bone reabsorption.…”

Section: Discussionmentioning

confidence: 99%

Periodontal disease related to oxidative stress

Katerina¹,

Dejanova²,

Petrovska³

et al. 2013

Ser J Exp Clin Res

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Th e study evaluates oxidative stress (OS) in patients with diff erent stages of periodontal disease (PD) and the infl uence of their smoking habits on OS. PD is related to connective tissue infl ammation, which leads to deterioration of the supporting structures of the tooth. OS is a condition characterised by overproduction of free radicals (FR), SAŽETAK Ova studija se bavi procenom oksidativnog stresa (OS) kod pacijenata sa različitim stadijumima oboljenja paradoncijuma -paradontopatija (PD), i uticaja pušačkih navika pacijenata. PD je povezana sa zapaljenjem vezivnih tkiva koje uzrokuje oštećenje tkivnog oslonca zuba. OS je stanje koje nastaje usled prevelike produkcije slobodnih radikala (SR) koji mogu biti uključeni u patogenezu PD, uzrokujući oštećenje paradontalnih tkiva i drugih bliskih tkiva. Pacijenti su bili podeljeni u sledeće grupe: I -nepušači (n=45), II -pušači (n=45), koji su razvrstani na osnovu stadijuma PD na: blag (1), umeren (2), težak (3) i kontrolnu grupu (n=30). SR su određivani pomoću D-Roms testa, ukupni antioksidativni kapacitet (UAK) pomoću

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Smoking influences salivary histamine levels in periodontal disease

Cited by 11 publications

References 63 publications

Total Antioxidant Capacity and Total Oxidant Status in Saliva of Periodontitis Patients in Relation to Bacterial Load

Total Antioxidant Capacity and Total Oxidant Status in Saliva of Periodontitis Patients in Relation to Bacterial Load

Saliva as a Source of Biomarkers for Periodontitis and Periimplantitis

Periodontal disease related to oxidative stress

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