Smoking Cessation in COPD Patients by a Selective Partial Nicotinic Agonist

Ianoși, Edith Simona; Postolache, Paraschiva; Macovei, Luana Andreea; Szathmary, Mioara; Szasz, Simona; Nemeș, Roxana Maria; Jimborean, Gabriela

doi:10.37358/rc.18.7.6413

Cited by 15 publications

(15 citation statements)

References 15 publications

(18 reference statements)

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“…Our study included patients hospitalized in ICU, aged between 18-64 years, with the aim of highlighting the MDR strains which caused infections in the active people which did not belong to the risk groups. We excluded from this study children under the age of 18 and elderly people (over 65 years), vulnerable age groups with particularities of the evolution of infection [15,16] and response to antibiotic therapy [17].…”

Section: Resultsmentioning

confidence: 99%

The Characterization of Antibiotic Resistance of Bacterial Isolates from Intensive Care Unit Patient Samples in a University Affiliated Hospital in Romania

Golli¹,

Niţu²,

Bălăşoiu³

et al. 2019

Rev. Chim.

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To determine the resistance pattern of bacterial pathogens involved in infections of the patients aged between 18-64 years, admitted in a ICU from a 1518-bed university-affiliated hospital. A retrospective study of bacterial pathogens was carried out on 351 patients aged between 18-64 years admitted to the ICU, from January to December 2017. In this study there were analysed 469 samples from 351 patients (18-64 years). A total of 566 bacterial isolates were obtained, of which 120 strains of Klebsiella spp. (35.39%%), followed by Nonfermenting Gram negative bacilli, other than Pseudomonas and Acinetobacter (NFB) (75- 22.12%), Acinetobacter spp. (53 - 15.63%), Pseudomonas aeruginosa and Proteus (51 - 15.04%), and Escherichia coli (49 - 14.45%). The most common isolates were from respiratory tract (394 isolates � 69.61%). High rates of MDR were found for Pseudomonas aeruginosa (64.70%), MRSA (62.65%) and Klebsiella spp. (53.33%), while almost all of the isolated NFB strains were MDR (97.33%). There was statistic difference between the drug resistance rate of Klebsiella and E. coli strains to ceftazidime and ceftriaxone (p[0.001), cefuroxime (p[0.01) and to cefepime (p[0.01). The study revealed an alarming pattern of antibiotic resistance in the majority of ICU isolates.

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Section: Resultsmentioning

confidence: 99%

The Characterization of Antibiotic Resistance of Bacterial Isolates from Intensive Care Unit Patient Samples in a University Affiliated Hospital in Romania

Golli¹,

Niţu²,

Bălăşoiu³

et al. 2019

Rev. Chim.

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“…[19,24]. The conditions that affect patient`s immunity, like cancer, lung and gastrointestinal diseases, increase the risk of MDR, contributing to the spread of MDR isolates [25][26][27][28][29]. The empirical, indiscriminate, prolonged, or incorrect usage of antibiotics contributes significantly to the selection of MDR strains [30,31].…”

Section: Resultsmentioning

confidence: 99%

Distribution of Pathogens Involved in Infections in Oncological Patients and their Antibiotic Resistance Profile

Golli¹,

Niţu²,

Bălăşoiu³

et al. 2020

Rev.Chim.

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Cancer is the second leading cause of death in Romania and worldwide. Cancer patients are at increasing risk of acquiring bacterial infection with multi-resistant germs, including multidrug-resistant (MDR) strains of Gram-negative bacteria involved in nosocomial infection. Romania is one of the South-Eastern European countries with one of the highest prevalence rates of MDR pathogens. To determine the resistance pattern of bacterial profile and antibiotic resistance pattern in cancer patients admitted at the County Emergency Clinical Hospital Craiova, Romania. A retrospective study of bacterial pathogens was carried out on 90 adult cancer patients admitted from January to December 2018. The analysis of the resistance patterns for the action of the appropriate antibiotics was performed using Vitek 2 Compact system and diffusion method. In this study there were analysed 92 samples from 90 oncological patients (37-86 years). A total of 157 bacterial isolates were obtained, of which 37 strains of Staphylococcus aureus (23.56%), followed by Streptococcus pneumoniae (23- 14.64%), Klebsiella spp. and Escherichia coli (22 - 14,01%). The most common isolates were from respiratory tract (86 isolates - 54.77%). High rates of MDR were found for E. coli (63.63%), MRSA (61,11%) and Klebsiella spp. (54,54%), while one third of the isolated strains of Pseudomonas aeruginosa, Acinetobacter spp. and Proteus spp. were MDR. The findings of this study may be the basis for further more extensive studies highlighting the germs involved in the infectious pathology of cancer patients, in order to determine the antimicrobial resistance and to improve the methods of prophylaxis and treatment. Keywords: multidrug resistance (MDR), cancer patients, bacterial pathogen

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“…Our study underlines the existence of an inflammatory response to smoking in foster care adolescents, a social category otherwise predisposed to various addictive behaviors. This suggests a higher risk for the development of smoking-related complications in these individuals and warrants further investigation of the clinical impact of these findings.The smokers had poor or moderate motivation for smoking cessation [21].…”

Section: Resultsmentioning

confidence: 99%

The Influence of Smoking on Nicotine Exposure Biomarkers and Inflammatory Profile Among Foster Care Teenagers, Romania

Budin¹,

Marginean²,

Bordea³

et al. 2019

Rev. Chim.

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Foster care young people have an increased overall risk for the development of chronic health conditions.Smoking is a major risk factor for many conditions with inflammatory component. We performed a cross-sectional pilot study to assess the correlation between tobacco consumption status and inflammatory profile among adolescents living with foster parents in the central region of Romania. A number of 35 teenagers aged 10-18 were enrolled. Blood samples were collected by venipuncture for complete blood count (CBC), fibrinogen, Interleukin-6 (IL 6), C reactive protein (CRP). Exhaled CO was measured and urine samples were collected in the same session for cotinine assessment. Of the 123 teenagers initially enrolled, 35 completed the entire study protocol. Urinary cotinine accurately reflected smoker status. Smoking did not affect hemoglobin levels or other hematological parameters in foster care teenagers. The value of C-reactive protein was higher in smokers. Plasma fibrinogen correlated with the daily number of cigarettes. Interleukin-6 did not correlate with the smoker status or the daily number of cigarettes consumed. Our study highlights the existence of an inflammatory response to smoking in foster care adolescents, a social category otherwise predisposed to various addictive behaviors.

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Smoking Cessation in COPD Patients by a Selective Partial Nicotinic Agonist

Cited by 15 publications

References 15 publications

The Characterization of Antibiotic Resistance of Bacterial Isolates from Intensive Care Unit Patient Samples in a University Affiliated Hospital in Romania

The Characterization of Antibiotic Resistance of Bacterial Isolates from Intensive Care Unit Patient Samples in a University Affiliated Hospital in Romania

Distribution of Pathogens Involved in Infections in Oncological Patients and their Antibiotic Resistance Profile

The Influence of Smoking on Nicotine Exposure Biomarkers and Inflammatory Profile Among Foster Care Teenagers, Romania

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